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Cystic Fibrosis: Opportunity Assessment and Forecast to 2034 - Update

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    Report

  • 94 Pages
  • September 2025
  • Region: Global
  • GlobalData
  • ID: 6169819
This report deliverables include a Pdf report and an Excel-based forecast model and covers the seven major markets (7MM: US, France, Germany, Italy, Spain, UK, and Canada). The base year of the sales forecast model is 2024, and the forecast period is 2024-2034. This report also includes a number of recent enhancement to the forecast models, specifically the US LoA analysis tab and the interactive patient flow tab. The patient flow tab helps to summarize the number of patients treated on each class of therapy for each year of the forecast period for the 7MM.

The analyst estimates that throughout the forecast period (2024-2034), 12-month diagnosed prevalent cases of cystic fibrosis (CF) are anticipated to increase in the 7MM, across all age-groups. Treatment rates will also increase because of roll-out of more newborn screening and genetic testing programs, improved life expectancy of patients, and anticipated increase in treatment options with the launch of novel CFTR modulators and pipeline agents. The CF pipeline in the 7MM remains limited with most of the pipeline targeting the CFTR, suggesting a shift from symptom management to disease targeting. The CF market is expected to grow from $11.1 billion in 2024 to $16.0 billion by 2034 at a compound annual growth rate (CAGR) of 3.8% across the 7MM.

Scope

  • Overview of cystic fibrosis (CF) - including epidemiology, disease etiology and management.
  • Topline CF drugs market revenue, annual cost of therapy, and anticipated sales for late-stage pipeline drugs.​
  • Key topics covered include assessment of marketed therapies and pipeline agents, unmet needs, pipeline assessment and market outlook for the US, 5EU, and Canada over the 10-year forecast period.​
  • Pipeline analysis: Emerging novel trends under development, and detailed analysis of late-stage pipeline drugs.​
  • Analysis of the current and future market competition in the seven-market CF therapeutics market. Insightful review of the key industry drivers and barriers.

Reasons to Buy

  • Develop and design your in-licensing and out-licensing strategies, using a detailed overview of current pipeline products and technologies to identify companies with the most robust pipelines.​
  • Develop business strategies by understanding the trends shaping and driving the seven-market cystic fibrosis (CF) therapeutics market.​
  • Drive revenues by understanding the key trends, innovative products and technologies, market segments, and companies likely to impact the seven-market CF market in the future.​
  • Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors.​
  • Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a competitive advantage.​
  • Track drug sales in the seven-market CF therapeutics market from 2024-2034.​
  • Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments and strategic partnerships.

Table of Contents

1. Preface
1.1. Contents
1.2. Abbreviations
1.3. Related Reports
2. Executive Summary
3. Disease Overview
3.1. Overview of Cystic Fibrosis
3.2. Etiology and Pathophysiology of Cystic Fibrosis
3.3. Classification of Cystic Fibrosis
3.4. Cystic Fibrosis SWOT Analysis
4. Epidemiology
4.1. Registry-Based Diagnosed Prevalent Cases of Cystic Fibrosis, N, Men and Women, 2024-34
4.2. Registry-Based Diagnosed Prevalent Cases by Age, N, Men and Women, All Ages, 2024
4.3. Registry-Based Diagnosed Prevalent Cases by Sex, N, Men and Women, All Ages, 2024
4.4. Registry-Based Diagnosed Prevalent Cases by Mutation, N, Men and Women, All Ages, 2024
4.5. Registry-Based Diagnosed Prevalent Cases by Mutation, N, Men and Women, All Ages, 2024
4.6. Registry-Based Diagnosed Prevalent Cases with MRSA Infection, N, Men and Women, All Ages, 2024
4.7. Adjusted Diagnosed Prevalent Cases of Cystic Fibrosis, N, Men and Women, 2024-34
4.8. Adjusted Diagnosed Prevalent Cases by Age, N, Men and Women, All Ages, 2024
4.9. Adjusted Diagnosed Prevalent Cases by Sex, N, Men and Women, All Ages, 2024
4.10. Adjusted Diagnosed Prevalent Cases by Mutation, N, Men and Women, All Ages, 2024
4.11. Adjusted Diagnosed Prevalent Cases with MRSA Infection, N, Men and Women, All Ages, 2024
4.12. Sources and Methodology for Registry-Based Diagnosed Prevalent Cases of Cystic Fibrosis
4.13. Sources and Methodology for Registry-Based Diagnosed Prevalent Cases of Cystic Fibrosis with MRSA Infection
4.14. Sources and Methodology for Adjusted Diagnosed Prevalent Cases of Cystic Fibrosis
4.15. Sources and Methodology for Diagnosed Prevalent Cases of Cystic Fibrosis by Mutation
4.16. Sources and Methodology - Registry-Based Diagnosed Prevalence of Cystic Fibrosis
4.17. Sources and Methodology - Adjusted Diagnosed Prevalence of Cystic Fibrosis
4.18. Sources and Methodology - Diagnosed Prevalence of Cystic Fibrosis by Mutation 4.19. Sources and Methodology - Diagnosed Prevalence of Cystic Fibrosis by MRSA Infection
5. Current Treatment Options
5.1. Treatment Paradigm
5.2. Current Treatment Options
5.3. Product Profile: Vertex Pharmaceuticals’ Kalydeco (ivacaftor)
5.4. Product Profile: Vertex Pharmaceuticals’ Orkambi (ivacaftor + lumacaftor)
5.5. Product Profile: Vertex Pharmaceuticals’ Symdeko/Symkevi (tezacaftor + ivacaftor and ivacaftor)
5.6. Product Profile: Vertex Pharmaceuticals’ Trikafta/Kaftrio (elexacaftor + tezacaftor + ivacaftor and ivacaftor)
5.7. Product Profile: Vertex Pharmaceuticals’ Alyftrek (deutivacaftor + tezacaftor + vanzacaftor calcium)
5.8. Product Profile: PERTs (Creon, Pancreaze, Pertzye, UltresaTM, and Zenpep)
5.9. Product Profile: Inhaled Antibiotics (tobramycin, aztreonam)
5.10. Product Profile: Roche’s Pulmozyme (dornase alfa)
5.11. Product Profile: Arna Pharma’s Bronchitol (mannitol)
5.12. Product Profile: Anti-Inflammatory Therapies (azithromycin, ibuprofen)
6. Patient Flow
6.1. Patient Flow: CF in 2024 Across the 7MM
7. Unmet Needs and Opportunities
7.1. Curative and Broader-Acting Therapies
7.2. Therapies for Chronic Lung Infection
7.3. Novel Mucolytic Therapies
7.4. Improvement of Treatment Compliance
8. R&D Strategies
8.1. Trends in Clinical Trials Design and Clinical Development
8.2. Trends in Deal-Making in Cystic Fibrosis
9. Pipeline Assessment
9.1. CF Pipeline Overview
9.2. Late-Stage Pipeline Agents for CF
9.3. Product Profile: 4D Molecular Therapeutics’ 4D-710
9.4. Product Profile: BiomX’s BX-004 9.5. Product Profile: Novabiotics’ Cysteamine/NM001/Lynovex
9.6. CF: Clinical Trials (Phase II/III) Overview
10. Market Outlook
10.1. CF Market Forecast
10.2. Market Drivers and Barriers
11. Appendix
11.1. Primary Research: KOL Information
11.2. Bibliography
11.3. About the Authors
12. Contact the Publisher

Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • Vertex Pharmaceuticals
  • Roche
  • Merck
  • Verona Pharma
  • 4D Molecular Therapeutics
  • BiomX
  • Novabiotics
  • Enterprise Therapeutics
  • Spirovant Sciences
  • Boehringer Ingelheim
  • Armata Pharmaceuticals
  • Arna Pharma