Plasmid Purification Market Report 2025

The plasmid purification market size has grown rapidly in recent years. It will grow from $1.97 billion in 2024 to $2.26 billion in 2025 at a compound annual growth rate (CAGR) of 14.9%. The growth observed during the historic period can be attributed to the increasing demand for recombinant proteins, growth in gene therapy research, rising vaccine development activities, expansion of the biotechnology and pharmaceutical industries, and a surge in personalized medicine initiatives.

The plasmid purification market size is expected to see rapid growth in the next few years. It will grow to $3.88 billion in 2029 at a compound annual growth rate (CAGR) of 14.5%. The growth projected for the forecast period can be attributed to the expanding applications of gene and cell therapies, rising demand for high-purity plasmid DNA in diagnostics, growth in synthetic biology research, increased use of automated plasmid purification systems, and a stronger focus on next-generation therapeutics development. Key trends during this period include automation of plasmid purification processes, integration of microfluidics for plasmid isolation, advancements in endotoxin-free purification methods, incorporation of artificial intelligence for process optimization, and miniaturization of plasmid purification devices.

The rising demand for gene therapies is expected to drive the growth of the plasmid purification market in the coming years. Gene therapy involves modifying or replacing defective genes to treat or prevent diseases, and its adoption is growing due to advances in genetic sequencing and diagnostics, which allow precise identification of disease-causing genes for targeted treatment. Plasmid purification plays a critical role in gene therapy development by providing high-quality, pure plasmid DNA essential for safe and efficient therapeutic applications. High-purity plasmid DNA supports scalable and reproducible isolation, reduces production bottlenecks, and improves outcomes in both research and biomanufacturing. For example, in December 2024, the American Society of Gene & Cell Therapy (ASGCT) reported that the US Food and Drug Administration (FDA) approved six gene therapy products in 2023, up from five approvals in 2022. This trend underscores the increasing reliance on high-quality plasmid DNA, which is fueling growth in the plasmid purification market.

Key players in the plasmid purification market are introducing innovative technologies to enhance efficiency, yield, and DNA purity. One such innovation is the automated plasmid maxi-prep purification system, which automatically isolates large quantities of high-purity plasmid DNA from bacterial cultures. This technology streamlines the purification process, ensures reproducibility, reduces contamination risks, and increases throughput. For instance, in June 2023, GenScript Biotech Corporation, a US-based biotechnology firm, launched the AmMag Quatro, a fully automated high-throughput plasmid maxi-prep system. Capable of processing 24 samples across four independent modules in about two hours, the platform uses magnetic silica bead technology to deliver transfection-grade plasmid DNA with low endotoxin levels and high supercoiled DNA content, making it ideal for both research and large-scale biomanufacturing applications.

In July 2023, Sartorius AG, a Germany-based biotechnology company, acquired Polyplus SAS, a France-based firm specializing in plasmid DNA purification solutions. This acquisition enables Sartorius to expand its upstream capabilities in cell and gene therapy manufacturing by integrating plasmid DNA supply and transfection reagent technologies into its portfolio, strengthening its position in the growing gene therapy market.

Major players in the plasmid purification market are Thermo Fisher Scientific Inc., Merck KGaA, Agilent Technologies Inc., Illumina Inc., Bio-Rad Laboratories Inc., Qiagen N.V., GenScript Biotech Corporation, Takara Bio Inc., Promega Corporation, Aldevron LLC, Sino Biological Inc., New England Biolabs Inc., Origene Technologies Inc., Applied Biological Materials, InvivoGen, Omega Bio-tek Inc., ABP Biosciences, Zymo Research Corporation, Lucigen Corporation, Oxford Genetics Ltd., Mirus Bio LLC, Norgen Biotek Corp., PlasmidFactory GmbH & Co. KG, Lamda Biotech.

North America was the largest region in the plasmid purification market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in plasmid purification market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa. The countries covered in the plasmid purification market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report’s Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The sudden escalation of U.S. tariffs and the consequent trade frictions in spring 2025 are severely impacting the pharmaceutical companies contend with tariffs on APIs, glass vials, and lab equipment inputs with few alternative sources. Generic drug makers, operating on razor-thin margins, are especially vulnerable, with some reducing production of low-profit medicines. Biotech firms face delays in clinical trials due to tariff-related shortages of specialized reagents. In response, the industry is expanding API production in India and Europe, increasing inventory stockpiles, and pushing for trade exemptions for essential medicines.

Plasmid purification is the process of isolating plasmid DNA from bacterial cells while removing proteins, RNA, and other cellular components, producing high-purity DNA suitable for downstream molecular biology applications. This process ensures that the DNA is intact, free from contaminants, and functional for experimental use.

The primary types of plasmid purification products include mini, midi, and maxi plasmid purification kits, reagents and consumables, instruments and systems, and others. Mini plasmid purification kits are designed for rapid isolation of small quantities of plasmid DNA, typically from 1-5 ml bacterial cultures, using technologies such as alkaline lysis, spin column, magnetic bead-based, and filter-based methods. These products are applied in genetic engineering, cloning, transfection, and vaccine development, serving end users including academic research institutions, pharmaceutical companies, biotechnology firms, and contract research organizations (CROs).

The plasmid purification market research report is one of a series of new reports that provides plasmid purification market statistics, including plasmid purification industry global market size, regional shares, competitors with a plasmid purification market share, detailed plasmid purification market segments, market trends and opportunities, and any further data you may need to thrive in the plasmid purification industry. This plasmid purification market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The plasmid purification market consists of revenues earned by entities by providing services such as plasmid isolation, extraction, quality testing, custom plasmid preparation, and analytical support for research and industrial applications. The market value includes the value of related goods sold by the service provider or included within the service offering. The plasmid purification market also includes sales of buffers, enzymes, endotoxin removal resins, plasmid extraction columns, nucleic acid binding membranes, and automated plasmid purification systems. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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