Portable Bioprocessing Bioreactors Market Report 2025

The portable bioprocessing bioreactors market size has grown rapidly in recent years. It will grow from $2.49 billion in 2024 to $2.8 billion in 2025 at a compound annual growth rate (CAGR) of 12.8%. The growth during the historic period can be attributed to the rising demand for on-site biopharmaceutical production, increasing adoption of personalized medicine, growing need for decentralized and point-of-care bioprocessing, expanding investments in biotechnology research and development, and the increasing prevalence of infectious diseases driving innovations in bioprocessing.

The portable bioprocessing bioreactors market size is expected to see rapid growth in the next few years. It will grow to $4.48 billion in 2029 at a compound annual growth rate (CAGR) of 12.4%. The growth during the forecast period can be attributed to the increasing adoption of continuous bioprocessing techniques, rising demand for portable bioprocessing in remote and resource-limited settings, growing emphasis on sustainable and eco-friendly bioprocessing methods, expanding investments in cell and gene therapy manufacturing, and heightened interest in green bioprocessing approaches. Key trends expected during the forecast period include the development of mobile biomanufacturing units, advanced miniaturization of bioreactor systems, innovations in real-time monitoring and analytics, integration of smart sensors for process optimization, and advancements in disposable bioreactor technologies.

The growing demand for gene therapies is expected to drive significant growth in the portable bioprocessing bioreactors market. Gene therapy involves modifying or replacing defective genes to treat or prevent diseases, and its demand is rising due to advancements in genetic sequencing and diagnostics that enable precise identification of disease-causing genes. Portable bioprocessing bioreactors support gene therapy development by providing flexible, on-site manufacturing in controlled, scalable environments. These systems reduce processing time and complexity, improving efficiency in producing personalized treatments. For example, in December 2024, the American Society of Gene & Cell Therapy (ASGCT) reported that the FDA approved six gene therapy products in 2023, up from five in 2022, reflecting the growing pipeline and demand.

Key market players are focusing on innovative portable bioprocessing systems to enhance scalability and process control. Single-use bioreactors are disposable systems using pre-sterilized bags instead of reusable vessels that allow faster setup, reduced contamination, and lower cleaning costs. In April 2025, Thermo Fisher Scientific launched the 5L DynaDrive single-use bioreactor, a portable system designed for seamless scaling from 1 to 5,000 liters. This system maintains consistent reactor performance and improves productivity by 27% compared to conventional glass bioreactors. Its compact benchtop design incorporates biobased films and BioTitan retention devices to reduce product loss and promote sustainability.

In December 2022, Merck & Co. acquired Erbi Biosystems to strengthen its therapeutic protein manufacturing capabilities. This acquisition enables scalable cell-based perfusion bioreactor processes ranging from 2 ml to 2,000 liters, accelerates innovation in Merck’s process solutions unit, and expands opportunities in novel modalities, including cell therapies. Erbi Biosystems specializes in portable, small-scale bioprocessing bioreactors, complementing Merck’s gene and cell therapy manufacturing initiatives.

Major players in the portable bioprocessing bioreactors market are Thermo Fisher Scientific Inc., Merck KGaA, GE Healthcare, Avantor Fluid Handling LLC, Cytiva Bioscience Holding Ltd., Sartorius AG, Getinge AB, Pall Corporation, ZETA Holding GmbH, Tecnic S.r.l., IKA-Werke GmbH & Co. KG, PBS Biotech Inc., Fabtech Technologies Ltd, Culture Biosciences Inc., Distek Inc., Solida Biotech Inc., Biosan Laboratories Ltd., CerCell A/S, FermEx Inc., Uma Pharmatech Machinery Pvt. Ltd.

North America was the largest region in the portable bioprocessing bioreactors market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in portable bioprocessing bioreactors market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa. The countries covered in the portable bioprocessing bioreactors market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report’s Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The sudden escalation of U.S. tariffs and the consequent trade frictions in spring 2025 are severely impacting the pharmaceutical companies contend with tariffs on APIs, glass vials, and lab equipment inputs with few alternative sources. Generic drug makers, operating on razor-thin margins, are especially vulnerable, with some reducing production of low-profit medicines. Biotech firms face delays in clinical trials due to tariff-related shortages of specialized reagents. In response, the industry is expanding API production in India and Europe, increasing inventory stockpiles, and pushing for trade exemptions for essential medicines.

Portable bioprocessing bioreactors are compact, mobile systems designed to enable controlled biological reactions and cell cultures outside traditional laboratory environments. They allow on-site bioprocessing with precise control over environmental conditions, enhancing flexibility and efficiency in both research and production.

The primary product types of portable bioprocessing bioreactors include single-use bioreactors, stainless steel bioreactors, glass bioreactors, multi-use bioreactors, and smart bioreactors. Single-use bioreactors are disposable, pre-sterilized cultivation systems intended for one-time applications in bioprocessing, eliminating the need for cleaning and sterilization between batches. Their modes of operation include batch, fed-batch, continuous, and perfusion bioreactors, and they are available in various capacities, such as 1-10 L, 10-50 L, 50-100 L, and 100-500 L. These bioreactors are applied in areas such as cell therapy and regenerative medicine, vaccine and biologic development, biopharmaceutical production, biologics and biosimilars manufacturing, and tissue engineering. They serve a broad range of end-users, including academic and research institutions, biopharmaceutical companies, contract research organizations (CROs), food and beverage manufacturers, and chemical and petrochemical industries.

The portable bioprocessing bioreactors market research report is one of a series of new reports that provides portable bioprocessing bioreactors market statistics, including portable bioprocessing bioreactors industry global market size, regional shares, competitors with a portable bioprocessing bioreactors market share, detailed portable bioprocessing bioreactors market segments, market trends and opportunities, and any further data you may need to thrive in the portable bioprocessing bioreactors industry. This portable bioprocessing bioreactors market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The portable bioprocessing bioreactors market consists of sales of hollow fiber bioreactors, fixed bed bioreactors, air-lift bioreactors, and wave-mixed bioreactors. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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