Cementless Total Knee Arthroplasty Market Report 2025

The cementless total knee arthroplasty size has grown rapidly in recent years. It will grow from $2.63 billion in 2024 to $2.95 billion in 2025 at a compound annual growth rate (CAGR) of 12.3%. The growth in the historic period can be attributed to the rising preference for long-lasting orthopedic implants, increasing adoption of biologically integrated joint replacements, a growing number of knee replacement surgeries among younger patients, the expansion of the aging population, and greater awareness of implant durability and longevity.

The cementless total knee arthroplasty market size is expected to see rapid growth in the next few years. It will grow to $4.64 billion in 2029 at a compound annual growth rate (CAGR) of 12%. The growth in the forecast period can be attributed to the increasing shift toward personalized knee implant designs, rising demand for revision-friendly knee replacement solutions, greater focus on minimizing implant loosening complications, the expansion of outpatient orthopedic surgical centers, and increasing healthcare expenditure. Key trends expected during this period include the integration of robotic-assisted alignment in cementless knee surgeries, the adoption of 3D-printed custom-fit cementless implants, the use of advanced biomimetic coatings to improve osseointegration, the introduction of modular component designs for flexible intraoperative adjustments, and the development of bioactive surface coatings.

The rising prevalence of knee osteoarthritis is anticipated to drive the growth of the cementless total knee arthroplasty market in the coming years. Knee osteoarthritis is a degenerative joint disorder that leads to pain, swelling, and stiffness in the knee, limiting a person’s mobility. The increase in knee osteoarthritis cases is largely attributed to the growing rates of obesity, as excess body weight adds stress to the knee joints, accelerating cartilage deterioration and joint damage. Cementless total knee arthroplasty addresses knee osteoarthritis by replacing damaged joint surfaces with prosthetic components that promote natural bone growth, providing long-term stability and enhanced joint function. For example, in March 2023, the Office for Health Improvement and Disparities, a UK government department, reported that in 2022, 17.6% of individuals aged 16 and older had a long-term musculoskeletal (MSK) condition, including arthritis or persistent back or joint issues, up from 17% in 2021. Consequently, the rising incidence of knee osteoarthritis is supporting the expansion of the cementless total knee arthroplasty market.

Key players in the cementless total knee arthroplasty market are concentrating on developing innovative products, such as next-generation 3D-printed implants, to enhance bone ingrowth, improve long-term implant fixation, and meet the functional needs of younger, more active patients. These next-generation 3D-printed implants are advanced orthopedic devices created using additive manufacturing technology with porous structures that replicate natural bone, encouraging bone growth into the implant surface for better long-term stability without relying on bone cement. For instance, in March 2022, DePuy Synthes Sales Inc., a US-based medical device company, launched the Attune cementless fixed bearing knee with affixium 3DP technology. This next-generation 3D-printed cementless knee implant is designed to provide advanced biological fixation and improved initial stability for active patients, utilizing a lattice structure with porosity similar to natural bone. This innovation is part of the company’s broader Attune knee portfolio and reflects the growing trend toward cementless fixation, aiming to improve patient outcomes, reduce revision rates, and support the needs of younger, more mobile patients.

In January 2024, Enovis Corporation, a US-based medical technology company, acquired LimaCorporate S.p.A. for an undisclosed amount. Through this acquisition, Enovis intends to accelerate its growth and expand its orthopedic reconstruction offerings by integrating Lima’s innovative implant solutions, including 3D-printed Trabecular Titanium implants and advanced shoulder revision systems, into its portfolio. This move is expected to enhance clinical outcomes, drive margin growth, and strengthen Enovis’ position in the rapidly expanding extremities market. LimaCorporate S.p.A., based in Italy, specializes in cementless total knee arthroplasty solutions.

Major players in the cementless total knee arthroplasty market are Johnson & Johnson, Stryker Corporation, Zimmer Biomet Holdings Inc., Smith & Nephew Plc, Enovis Corporation, CONMED Corporation, Globus Medical Inc., MicroPort Scientific Corporation, Medacta Group SA, B. Braun Melsungen SE, TTK Healthcare Limited, Waldemar Link GmbH & Co. KG, United Orthopedic Corporation, Symbios Orthopédie SA, Gruppo Bioimpianti S.p.A., Permedica Orthopaedics S.p.A., Uteshiya Medicare Private Limited, LINK Orthopaedics GmbH, Plus Orthopaedics India Pvt. Ltd., and XLO India Pvt. Ltd.

North America was the largest region in the cementless total knee arthroplasty market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in cementless total knee arthroplasty market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa. The countries covered in the cementless total knee arthroplasty market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report’s Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The fast surge in U.S. tariffs and the trade tensions that followed in spring 2025 are heavily affecting the medical equipment sector, particularly for imported imaging machine components, surgical-grade stainless steel, and plastic disposables. Hospitals and clinics resist price hikes, pressuring manufacturers’ margins. Regulatory hurdles compound the problem, as tariff-related supplier changes often require re-certification of devices, delaying time-to-market. Companies are mitigating risks by dual-sourcing critical parts, expanding domestic production of commoditized items, and accelerating R&D in cost-efficient materials.

Cementless total knee arthroplasty is a surgical procedure in which a damaged knee joint is replaced with an artificial implant designed to encourage natural bone growth into the implant’s surface, ensuring long-term fixation without the use of bone cement. This method relies on porous or specially coated implant surfaces to achieve biological integration with the patient’s bone and is typically recommended for patients with good bone quality to provide stable and durable joint function.

The primary product types of cementless total knee arthroplasty include fixed-bearing and mobile-bearing implants. Fixed-bearing implants feature a securely attached polyethylene insert that delivers stable and long-lasting joint movement. These implants are manufactured using materials such as titanium, cobalt-chromium, polyethylene, and ceramic. Distribution channels include direct sales, distributors, and resellers, with applications in both primary and revision total knee arthroplasty. Key end users include hospitals, specialty clinics, ambulatory surgery centers, and other healthcare facilities.

The cementless total knee arthroplasty market research report is one of a series of new reports that provides cementless total knee arthroplasty market statistics, including cementless total knee arthroplasty industry global market size, regional shares, competitors with the cementless total knee arthroplasty market share, cementless total knee arthroplasty market segments, market trends, and opportunities, and any further data you may need to thrive in the cementless total knee arthroplasty industry. This cementless total knee arthroplasty market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The cementless total knee arthroplasty market consists of sales of femoral components, tibial components, patellar components, and 3D-printed cementless implants. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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