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This level of support has ensured that discoveries in universities such as Cornell and UC Davis are quickly translated into field practices that growers adopt in orchards and greenhouses. Certification bodies including OMRI and GlobalGAP have integrated biological inputs into organic and low residue programs, which matters for producers aiming to supply supermarkets and international buyers with strict residue requirements.
North American farmers who sell apples, grapes, tomatoes and leafy greens to export markets have been among the earliest adopters because biologically derived sprays and semiochemicals allow them to meet international residue limits. Farmer education programs run through land grant universities and extension networks have made these technologies familiar to growers, showing how microbial foliar applications and beneficial insects can be used together in integrated pest management.
According to the research report "North America Biorationals Market Outlook, 2030,", the North America Biorationals market was valued at more than USD 1.46 Billion in 2024. In January 2023 Valent BioSciences acquired FBSciences Holdings to strengthen its lineup in biostimulants and biopesticides, expanding its capacity to deliver plant and soil health products under the backing of Sumitomo Chemical. In the same year Certis Biologicals launched MeloCon LC, a liquid concentrate formulated with a naturally occurring soil fungus that targets harmful nematodes and provides flexibility for growers working in both organic and conventional systems.
FMC Corporation created a partnership with Syngenta Crop Protection to distribute biological seed treatments in Canada, a step that pushed these products into wider commercial channels. Koppert Biological Systems reported a double digit increase in sales of beneficial insect products in 2023, reflecting stronger demand for sustainable pest control in greenhouse and field crops. Marrone Bio Innovations announced successful vineyard trials of a new plant extract based fungicide that performed as well as synthetic options while remaining eligible for organic certification.
These moves show that major corporations, innovative startups and biological specialists are building a market that no longer competes on promises alone but delivers real alternatives on farm. Investments in microbial discovery, improved formulations and digital decision tools are creating a new layer of competitive advantage and at the same time supermarkets and exporters are rewarding growers who adopt these inputs with stronger access to residue sensitive markets. North America has become a proving ground where corporate deals, new product launches and rising farmer demand intersect to make biorationals a central part of the agricultural input industry.
Market Drivers
- Regulatory support through EPA’s Biopesticide Division: The US Environmental Protection Agency has established a streamlined approval pathway for biopesticides, which shortens registration timelines and lowers costs compared to synthetic pesticides. This regulatory clarity gives companies confidence to invest in developing and launching new biorational products. Farmers benefit by having faster access to innovative solutions that meet residue and environmental safety requirements, making regulation a key driver in the adoption of biorationals across North America.
- High-value crop and organic farming demand: North America has a strong focus on high-value crops such as fruits, vegetables, nuts, and greenhouse produce, which face strict residue standards for both domestic and export markets. The large organic farming sector, backed by USDA Organic certification, further fuels demand for approved biological inputs. Farmers growing crops for premium markets are especially motivated to adopt biorationals that deliver effective pest control without leaving harmful residues, ensuring compliance with retailer and consumer expectations.
Market Challenges
- Limited farmer awareness and training: Although the US and Canada lead in biopesticide research, many farmers still lack adequate training on how to integrate these products into conventional pest management programs. Misuse or poor timing can reduce effectiveness, which creates skepticism about performance. Extension services and demonstration projects are working to bridge this knowledge gap, but farmer education remains a key challenge in expanding adoption across wider cropping systems.
- Higher costs and storage limitations: Biorationals often have shorter shelf lives and stricter storage requirements compared to synthetic pesticides. Some microbial products are sensitive to temperature and moisture, which can make distribution and on-farm storage more difficult. Their price point is also generally higher, which can deter adoption among growers who operate on thin margins or who are accustomed to cheaper chemical alternatives. This cost and logistics barrier continues to be a limiting factor in broader market penetration.
Market Trends
- Integration with precision agriculture: North American farms are at the forefront of adopting digital agriculture tools such as drones, remote sensors, and AI-driven decision support systems. Biorationals are increasingly being applied through these precision systems, which optimize dosage, timing, and coverage. This trend not only boosts efficacy but also enhances farmer confidence by reducing variability in performance, making biopesticides a natural fit for high-tech agriculture.
- Mergers, acquisitions, and partnerships in biologicals: Large agrochemical companies like Bayer, Corteva, BASF, and Syngenta have expanded their biological divisions through acquisitions and partnerships with biotech innovators. Startups specializing in microbial discovery, RNAi-based products, and semiochemicals are being acquired or funded to strengthen product pipelines. This consolidation trend ensures that biologicals are no longer niche but integrated into mainstream crop protection portfolios, accelerating their availability and adoption in the North American market.Semiochemicals are expanding fastest because they provide residue-free, species-specific pest control that aligns with strict US and Canadian standards for food safety and export compliance.
This level of selectivity protects pollinators like bees and natural predators that are essential to orchard and vineyard ecosystems. Regulatory agencies such as the EPA and Canada’s PMRA also favor semiochemicals because of their low toxicity and environmental safety, which means they are often approved faster than conventional pesticides and face fewer restrictions. The technology behind semiochemicals has advanced, with aerosol puffers and controlled-release dispensers becoming standard tools for fruit growers, making application easier and more reliable.
Universities such as Cornell and UC Davis have played a major role in testing and validating semiochemical use in integrated pest management programs, giving growers confidence in their performance. Food retailers and processors, who impose some of the strictest limits on pesticide residues, actively encourage their use by growers supplying fresh fruit and wine grapes. Moreover, the adoption of semiochemicals fits perfectly with the broader sustainability narratives in North America, as consumers increasingly demand environmentally friendly food production.
Insecticides dominate because insect pests cause the most significant economic damage in North America’s high-value crops, and biorational insecticides provide effective control with residue and resistance management benefits.
In North America, insect pests remain the most costly threat to agricultural production, particularly in fruit, vegetable, and nut crops, which are critical both for domestic consumption and export. Pests such as codling moth in apples, spotted wing drosophila in berries, Colorado potato beetle in potatoes, and corn rootworm in maize cause billions of dollars in losses if not effectively controlled. Farmers have long relied on chemical insecticides, but resistance has become a growing problem, forcing them to integrate alternatives.
Biorational insecticides like Bacillus thuringiensis (Bt), spinosad, neem extracts, and entomopathogenic fungi such as Beauveria bassiana have become essential tools because they control target pests while minimizing harm to beneficial organisms and leaving little to no residue. Bt formulations are widely used in vegetable production, while spinosad has become a standard in organic fruit farming. These products fit seamlessly into integrated pest management programs and are approved under USDA Organic standards, giving them wide acceptance among both conventional and organic growers. Regulatory agencies support their use because they present low risks to human health and the environment, which has sped up their availability.
Large agrochemical companies have also prioritized biorational insecticide development, ensuring steady supply and farmer training. Insect pests have short life cycles and can quickly develop resistance to single control measures, but biorational insecticides, when rotated with conventional chemistries, provide resistance management benefits that farmers find invaluable.
Fruits and vegetables are driving growth because these crops face strict residue limits and cosmetic quality demands, making biorationals the preferred option for growers.
The fruits and vegetables sector in North America is the natural leader in adopting biorationals because these crops require the highest levels of care in pest management and quality control. Unlike grains or oilseeds, fruits and vegetables are sold fresh and are judged by consumers on appearance, texture, and taste, which leaves no room for blemishes caused by pests or diseases. Supermarkets and food processors impose strict private residue standards that often go beyond federal regulations, so growers of crops like apples, grapes, lettuce, strawberries, and tomatoes must ensure their produce meets these requirements.
Biorationals such as microbial fungicides, neem-based insecticides, and pheromone traps provide residue-free solutions that can be applied close to harvest without jeopardizing compliance. In export-oriented regions like California, Washington, and British Columbia, growers must also meet the maximum residue levels of international buyers in Europe and Asia, making biorationals even more critical. Greenhouse vegetable producers, especially in Canada and the northern US, rely heavily on biological control agents and microbial sprays because enclosed environments make chemical residues more risky and beneficial insect populations more vulnerable.
The organic farming sector in fruits and vegetables is also expanding rapidly, and USDA Organic-approved biorationals are essential inputs in that system. Universities and extension services have developed detailed integrated pest management programs for fruit and vegetable growers that heavily incorporate biologicals, making adoption smoother. For farmers, these solutions not only help them meet residue standards but also allow them to market produce as environmentally friendly, which aligns with consumer expectations.
Dry formulations are growing fastest because they are more stable, easier to transport, and widely used in seed treatments and soil applications.
In North America, dry formulations of biorationals have become increasingly popular because they solve several practical challenges associated with biological products. Liquids often require cold storage and have limited shelf lives, which complicates distribution across vast farming regions like the Midwest and Western US. Dry forms such as wettable powders, dusts, and granules are more stable under ambient conditions, easier to transport, and cheaper to store, making them more convenient for farmers and distributors alike.
Seed treatment is a major application area in North America’s large-scale grain and corn farming, and most biological seed treatments are sold in dry formulations because they coat seeds effectively and remain stable until planting. Dry microbial powders of Trichoderma and Bacillus are widely used in horticulture and field crops for soil-borne disease control, while granular formulations of entomopathogenic fungi are applied in crops like sugarcane and maize to manage soil-dwelling pests. Farmers prefer these formats because they are easy to handle, compatible with existing application equipment, and can be stored for longer periods without special infrastructure.
In regions with extreme weather, from the hot and dry climates of the US Southwest to the colder regions of Canada, dry products offer reliability that liquid formulations often lack. The logistical advantages, combined with their suitability for diverse application methods, make dry formulations the fastest-growing form segment in North America’s biorational market.
Foliar sprays dominate because they are the most direct and widely adopted method for applying biorationals to manage pests and diseases in high-value crops.
Foliar spraying remains the most common application method in North America because it offers farmers an immediate and flexible way to protect crops from pests and diseases. High-value crops such as apples, grapes, tomatoes, peppers, and leafy greens are especially vulnerable to foliar pathogens like powdery mildew and insect pests like aphids and caterpillars, and foliar sprays deliver biologicals directly to the site of infection or infestation. Microbial fungicides such as Bacillus-based products are often applied as foliar sprays to prevent disease outbreaks, while Bt and neem formulations are sprayed to control caterpillars and sucking pests.
This method is well established because farmers already own spraying equipment and are accustomed to the practice from conventional pesticide use, so adopting biological foliar sprays requires no new infrastructure. Foliar sprays also allow for flexibility in timing, with products applied as preventive or curative treatments depending on pest pressure. In greenhouse vegetable production across Canada and the northern US, foliar sprays are an integral part of integrated pest management, working alongside beneficial insects and environmental controls.
The regulatory advantage of biorational sprays is also important, as many can be applied close to harvest without exceeding residue limits, which gives growers a critical tool to maintain crop quality for fresh produce markets. Extension programs and university IPM guides strongly emphasize foliar application of biorationals because of its practicality and proven results. The United States leads because of its strong regulatory framework, advanced research ecosystem, and early commercial adoption of biorationals in high-value crops.
The US stands out in North America’s biorational market because it has all the critical enablers working together, a supportive regulatory pathway, a world-class research infrastructure, and a farming system that is highly diversified and export-oriented. The Environmental Protection Agency runs a dedicated Biopesticides and Pollution Prevention Division, which evaluates and registers biologicals faster and more affordably than synthetic chemicals, giving companies confidence to invest in new products.
Public institutions like USDA’s Agricultural Research Service and leading universities such as Cornell, UC Davis, and University of Florida have long traditions of developing microbial insecticides, fungal bioagents, and pheromone-based pest control systems, and this research often translates into commercial products. Private industry has also been quick to move: companies like Marrone Bio Innovations, Valent BioSciences, and Certis Biologicals emerged in the US as pioneers of microbial and botanical inputs, while multinational majors such as Bayer and FMC have expanded biological divisions here due to the regulatory clarity and market demand.
The US market is characterized by high-value crops like berries, leafy greens, nuts, and orchard fruits, which are highly sensitive to pesticide residues and consumer scrutiny, creating a natural pull for residue-free pest solutions. The organic farming movement in the US, backed by OMRI certification and USDA organic standards, further accelerated acceptance of biopesticides among both growers and retailers. Consumer preferences also matter greatly, with supermarket chains and food processors enforcing residue-limit policies stricter than government rules, which drives adoption of biorationals to ensure compliance.
In addition, the US has an advanced precision agriculture sector, where drones, sensors, and decision support systems integrate seamlessly with biological products, improving application efficiency and reducing the perceived risk of using biopesticides. Farmer cooperatives, extension services, and state-level IPM programs actively promote non-chemical alternatives, making biorationals part of the mainstream discussion rather than a niche solution.
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Table of Contents
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- BASF SE
- Koppert B.V.
- Bayer AG
- Syngenta Global AG
- FMC Corporation
- Corteva, Inc.
- SIPCAM OXON S.p.a.
- Gowan Company, LLC
- Biobest Group N.V.
- Suterra LLC
- Bioceres Crop Solutions Corp
- Valent BioSciences LLC
- Certis USA LLC
- Vestaron Corporation
- Agralan Ltd
- Russell IPM
- Rentokil Initial Plc
- Andermatt Biocontrol AG
- Bionema Group Limited
- UPL Limited