Protein Purification Equipment Global Market Report 2025

The protein purification equipment market size has grown strongly in recent years. It will grow from $5.09 billion in 2024 to $5.52 billion in 2025 at a compound annual growth rate (CAGR) of 8.5%. The growth in the historic period can be attributed to the expansion of academic expertise in molecular and protein sciences, the rise in recombinant therapeutic manufacturing activities, the increasing adoption of laboratory-scale automation and single-use technologies, the growth of contract development and manufacturing capabilities, and the surge in public and private investments toward life science infrastructure development.

The protein purification equipment market size is expected to see strong growth in the next few years. It will grow to $7.55 billion in 2029 at a compound annual growth rate (CAGR) of 8.1%. The growth in the forecast period can be attributed to the rising demand for scalable single-use purification modules, increasing need for continuous downstream processing solutions, expanding adoption of integrated process automation in manufacturing, growth of regional bioprocessing and vaccine production hubs, and accelerating investments in proteomics-driven therapeutic pipelines. Major trends expected during the forecast period include the emergence of advanced purification systems, progress in miniaturized chromatography and membrane technologies, innovations in customized affinity ligands and high-capacity resins, advancements in real-time monitoring, and the adoption of digital twins and advanced process analytics.

The increasing emphasis on personalized medicine is expected to drive the growth of the protein purification equipment market in the coming years. Personalized medicine tailors medical treatment to an individual’s unique genetic makeup, environment, and lifestyle, particularly for chronic and genetic disorders. The growing adoption of this approach is fueled by the rising demand for targeted therapies for complex and hard-to-treat diseases. Protein purification equipment plays a crucial role in isolating and analyzing specific proteins, facilitating the development of patient-specific therapies. For example, in February 2024, the Personalized Medicine Coalition, a U.S.-based non-profit organization, reported that the FDA approved 16 new personalized treatments for patients with rare diseases in 2023, up from six approvals in 2022. This increasing focus on personalized medicine is driving the growth of the protein purification equipment market.

Leading companies in the protein purification equipment market are advancing their technological capabilities to improve precision, purity, and throughput in protein isolation processes. These advancements enable efficient purification of target proteins while maintaining their structural and functional integrity for research and therapeutic use. For instance, in November 2023, Cytiva, a U.S.-based biotechnology firm, introduced Protein Select, a next-generation protein purification technology. The system uses a self-cleaving traceless tag and a compatible affinity chromatography resin to standardize protein purification across different protein types without requiring specific binding partners. This innovation allows researchers to obtain highly pure, native proteins through a simplified and efficient process, enhancing speed and reproducibility.

In June 2023, Biotage AB, a Sweden-based life sciences company, acquired Astrea Bioseparations for an undisclosed amount. This acquisition enables Biotage to expand its chromatography solutions into biologics and advanced therapeutics, strengthen its recurring consumables revenue, and broaden its portfolio beyond small-molecule purification systems. Astrea Bioseparations, based in the UK, is a manufacturer specializing in protein purification equipment.

Major players in the protein purification equipment market are Roche Diagnostics, Repligen Corporation, Thermo Fisher Scientific Inc., Danaher Corporation, Merck KGaA, GE Healthcare Technologies Inc., Becton, Dickinson and Company (BD), ECOLAB Inc., Lonza Group Ltd., Tosoh Corporation, Agilent Technologies Inc., Sartorius AG, Shimadzu Corporation, PerkinElmer Inc., Waters Corporation, JSR Corporation, Bio-Rad Laboratories inc., Qiagen N.V., Tecan Group Ltd., Eppendorf AG, Bio-Techne Corporation, Promega Corporation, Takara Bio Inc., Biotage AB, Shanghai Biotechnology Corporation, I&L Biosystems GmbH, LabGeni, PromoChrom Technologies Ltd., Inscinstech Co. Ltd., and Taidu Biotech Co. Ltd.

North America was the largest region in the protein purification equipment market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in protein purification equipment report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report’s Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The sudden escalation of U.S. tariffs and the consequent trade frictions in spring 2025 are severely impacting the pharmaceutical companies contend with tariffs on APIs, glass vials, and lab equipment inputs with few alternative sources. Generic drug makers, operating on razor-thin margins, are especially vulnerable, with some reducing production of low-profit medicines. Biotech firms face delays in clinical trials due to tariff-related shortages of specialized reagents. In response, the industry is expanding API production in India and Europe, increasing inventory stockpiles, and pushing for trade exemptions for essential medicines.

The protein purification equipment market research report is one of a series of new reports that provides protein purification equipment market statistics, including protein purification equipment industry global market size, regional shares, competitors with a protein purification equipment market share, detailed protein purification equipment market segments, market trends and opportunities, and any further data you may need to thrive in the protein purification equipment industry. This protein purification equipment market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

Protein purification equipment comprises specialized instruments and systems designed to isolate and purify proteins from complex biological samples. These systems enable the extraction of proteins in a refined form by separating them based on their unique physical and chemical properties. They are engineered to preserve protein integrity, ensure precise separation, and deliver consistent, high-purity, and reliable results.

The primary product categories of protein purification equipment include chromatography systems, electrophoresis systems, protein fractionation systems, protein concentration systems, and others. Chromatography systems are laboratory and industrial instruments used to separate, identify, and purify the components of complex mixtures based on characteristics such as size, charge, or molecular affinity. The technologies employed include ion exchange chromatography, affinity chromatography, size exclusion chromatography, high-performance liquid chromatography (HPLC), and others. These systems are utilized in various applications such as drug discovery, vaccine production, and genetic engineering and are used by pharmaceutical and biotechnology companies, academic and research institutions, contract research organizations, and other end users.

The countries covered in the protein purification equipment market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The protein purification equipment market consists of sales of filtration units, sample preparation instruments, buffer exchange systems, protein purification resins, and protein desalting devices. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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