2D Cell Culture Global Market Report 2025

The 2D cell culture market size has grown rapidly in recent years. It will grow from $4.81 billion in 2024 to $5.3 billion in 2025 at a compound annual growth rate (CAGR) of 10.1%. The growth during the historic period can be attributed to the rise in academic collaborations, the increasing use of 2D cell cultures in toxicology studies, the expansion of pharmaceutical outsourcing, the growing interest in cell biology education, and the rising demand for cost-effective testing models.

The 2D cell culture market size is expected to see strong growth in the next few years. It will grow to $7.7 billion in 2029 at a compound annual growth rate (CAGR) of 9.8%. The growth during the forecast period can be attributed to the increasing need for high-throughput screening, the rising demand for cell-based vaccines, the expansion of biotechnology startups, the growing focus on biologics development, and the increasing use of 2D cell cultures in infectious disease research. Key trends in the forecast period include the emergence of lab-on-a-chip platforms, integration with automated systems, development of synthetic biomaterials, advancements in nanotechnology applications, and the growing application of data analytics in cell culture processes.

The growing demand for personalized medicine is expected to drive the expansion of the 2D cell culture market in the coming years. Personalized medicine is a healthcare approach that customizes treatment and prevention strategies based on an individual’s genetic profile, lifestyle, and environment, instead of applying a universal treatment method. The increasing interest in personalized medicine is fueled by improved treatment outcomes, as it offers targeted therapies that are more effective and have fewer adverse effects. This approach enables faster recovery and enhances patients’ quality of life. The rising need for personalized medicine boosts the demand for 2D cell culture, as it allows researchers to cultivate and analyze patient-specific cells, facilitating the study of individual drug responses and the creation of customized treatment plans. For example, in February 2024, the Personalized Medicine Coalition, a US-based non-profit organization, reported that the FDA approved 16 new personalized treatments for patients with rare diseases in 2023, compared to six in 2022. Hence, the growing demand for personalized medicine is contributing to the growth of the 2D cell culture market.

Leading companies in the 2D cell culture market are concentrating on the development of advanced biomaterials, such as thin hydrogel coatings for 2D substrates, to enhance cell attachment, replicate natural tissue environments, and increase experimental consistency. Thin hydrogel coatings for 2D substrates are specialized surface layers that provide a biomimetic, cell-compatible setting to improve cell adhesion, proliferation, and functionality in 2D cultures. For example, in September 2025, TheWell Bioscience Inc., a US-based biotechnology company, launched an innovative xeno-free biomimetic hydrogel system. This platform is designed to support both 2D and 3D neuronal cell cultures, as well as injectable delivery for in vivo applications. It aims to promote neuroregenerative research by closely replicating the natural cellular environment and also supports advancements in precision medicine, cell therapy, and biomanufacturing. Overall, this innovation marks a major advancement in the development of effective cell-based therapies.

In April 2023, AnaBios Corporation, a US-based provider of cells derived from organs such as the brain, liver, kidney, eye, and lung, including specialized endothelial cells, acquired Cell Systems for an undisclosed amount. This acquisition enables AnaBios to offer human tissue samples, primary human cells, and human-focused ex vivo services for research in drug discovery and safety evaluation. Cell Systems is a US-based company that supplies products for cell culture, including 2D cell culture.

Major players in the 2d cell culture market are Tecan Group Ltd., Roche Holding AG, Thermo Fisher Scientific Inc., Takara Bio Inc., Danaher Corporation, Merck KGaA, GE Healthcare, Corning Incorporated, Becton Dickinson and Company (BD), Lonza Group AG, Agilent Technologies Inc., Sartorius AG, PerkinElmer Inc., Bio-Rad Laboratories Inc., Eppendorf AG, Bio-Techne Corporation, STEMCELL Technologies Inc., Greiner Bio-One International AG, Promega Corporation, BICO Group AB, Cedarlane Laboratories Ltd., Creative Bioarray Inc., PromoCell GmbH, Biolamina AB, HiMedia Laboratories Pvt. Ltd., 3H Biomedical AB, Cell Microsystems Inc., and AlveoliX AG.

North America was the largest region in the 2D cell culture market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in 2D cell culture report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report’s Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The sudden escalation of U.S. tariffs and the consequent trade frictions in spring 2025 are severely impacting the pharmaceutical companies contend with tariffs on APIs, glass vials, and lab equipment inputs with few alternative sources. Generic drug makers, operating on razor-thin margins, are especially vulnerable, with some reducing production of low-profit medicines. Biotech firms face delays in clinical trials due to tariff-related shortages of specialized reagents. In response, the industry is expanding API production in India and Europe, increasing inventory stockpiles, and pushing for trade exemptions for essential medicines.

The 2D cell culture market research report is one of a series of new reports that provides 2D cell culture market statistics, including the 2D cell culture industry global market size, regional shares, competitors with the 2D cell culture market share, detailed 2D cell culture market segments, market trends, and opportunities, and any further data you may need to thrive in the 2D cell culture industry. This 2D cell culture market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

2D cell culture is a laboratory method used to grow cells on flat, rigid surfaces such as glass or plastic, allowing the formation of a single-layered structure. It provides a controlled setting for studying cell behavior, biological mechanisms, and drug responses. This technique remains widely used due to its simplicity, cost efficiency, and reproducibility, making it a standard method in research and drug development.

The primary types of 2D cell cultures include skin cells, lung cells, brain cells, kidney cells, liver cells, breast cells, and others. Skin cells refer to in vitro cultured cells used for research, drug testing, and disease modeling in dermatology and related fields. The technique utilizes various technologies, including 2D cell culture platforms, microfluidics technology, automated cell culture systems, incubation and analysis systems, and culture monitoring and control systems. The major application areas include pharmaceuticals, stem cell research, bioproduction, food applications, bioenergy, environmental testing and toxicology, and agriculture. The main end users include pharmaceutical companies, biotechnology companies, contract research organizations, and academic research institutes.

The countries covered in the 2D cell culture market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The 2D cell culture market consists of revenues earned by entities by providing services such as cell line development, cell banking, assay development, and cytotoxicity testing. The market value includes the value of related goods sold by the service provider or included within the service offering. The 2D cell culture market also includes sales of culture media, petri dishes, flasks, and multiwall plates. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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