Supercritical Carbon Dioxide (CO2) Drying Chemical Global Market Report 2025

The supercritical carbon dioxide (co₂) drying chemical market size has grown strongly in recent years. It will grow from $1.83 billion in 2024 to $1.99 billion in 2025 at a compound annual growth rate (CAGR) of 8.9%. The growth in the historic period resulted from rising adoption in pharmaceutical and biotechnology sectors, growing demand for environmentally friendly drying processes, increasing use in specialty chemical applications, expanding utilization of supercritical CO₂ drying equipment, and heightened interest in sustainable drying technologies.

The supercritical carbon dioxide (co₂) drying chemical market size is expected to see strong growth in the next few years. It will grow to $2.77 billion in 2029 at a compound annual growth rate (CAGR) of 8.6%. The growth in the forecast period will be driven by increasing demand for high-purity chemicals, rising adoption of advanced drying technologies, expanding applications across pharmaceuticals, stricter environmental regulations supporting green solvents, and greater use of automation. Major trends in the forecast period include advancements in nano-encapsulation techniques, development of energy-efficient drying systems, innovations in multifunctional additives, progress in performance optimization, and new solutions targeting high-purity chemical production.

The growing investments in research and development (R&D) are expected to drive the expansion of the supercritical carbon dioxide (CO₂) drying chemical market. R&D refers to systematic efforts aimed at acquiring new knowledge and applying it to create improved products, processes, or services. The increase in R&D spending is primarily fueled by technological advancements and automation, as companies strive to innovate and stay competitive in evolving markets. Higher R&D investments enable businesses to enhance supercritical fluid technologies, optimize extraction processes, refine critical point drying methods, and create more cost-effective equipment for use in industries such as pharmaceuticals, food processing, and aerogel production. For instance, in February 2025, the National Center for Science and Engineering Statistics (NCSES), a U.S.-based government agency, reported that U.S. research and development spending increased from $892 billion in 2022 to $940 billion in 2023, reflecting a rise of $48 billion. As a result, these growing R&D investments are contributing to the growth of the supercritical CO₂ drying chemical market.

Companies in the supercritical CO₂ drying chemical market are focusing on developing innovative solutions, such as pilot-scale supercritical CO₂ lyophilization, to improve drying efficiency, preserve material integrity, and support scalable production for high-value applications. Pilot-scale CO₂ lyophilization refers to using supercritical CO₂ for freeze-drying or dehydrating materials at an intermediate scale, which allows for optimized processes and smoother scale-ups. For example, in January 2024, Thar Process, Inc., a U.S.-based technology and engineering company, introduced the SuperDry 9000 system, a versatile CO₂ lyophilization platform tailored for drug discovery and Good Manufacturing Practice (GMP) drug development labs. This system can handle both spray- and freeze-drying of pharmaceuticals, biomolecules, fine chemicals, and natural or inorganic materials, enhancing productivity while preserving material structure and supporting more efficient, precise drying operations in both research and manufacturing environments.

In April 2025, Kelvion, a German company known for its 3D-printed heat exchangers, partnered with the ESCO project to further innovate supercritical CO₂ systems. The collaboration focuses on developing next-generation 3D-printed heat exchangers designed for supercritical CO₂ applications. Through this partnership, Kelvion aims to enhance the efficiency, heat transfer capabilities, and operational reliability of supercritical CO₂-based processes, including CO₂ drying applications. The ESCO project, a Belgium-based initiative, is dedicated to advancing energy-efficient supercritical CO₂ technologies, with a particular focus on industrial process applications.

Major companies operating in the supercritical carbon dioxide (co₂) drying chemical market are Siemens Energy, Linde plc, Air Liquide S.A., Nippon Sanso Holdings Corporation, Chart Industries, Techno Project Industriale(TPI), Amar Equipment Pvt. Ltd., Feyecon, Accudyne Systems Inc, LABOAO, Applied Separations Inc., Natex Prozesstechnologie GesmbH, NovaSterilis Inc., Tousimis Research Corporation, Chemtron Science Laboratories Pvt Ltd, Bright Renewables B.V., Eurotechnica GmbH, ILSHIN AUTOCLAVE CO. LTD., Separeco S.r.l., Akay Natural Ingredients Private Limited, SFE Process

North America was the largest region in the supercritical carbon dioxide (co₂) drying chemical market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in supercritical carbon dioxide (co₂) drying chemical report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa. The countries covered in the supercritical carbon dioxide (co₂) drying chemical market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report’s Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The intensifying U.S. tariffs and escalating trade tensions in spring 2025 are expected to have a significant impact on the chemicals sector, which is bearing a disproportionate burden, particularly from tariffs on petrochemicals and intermediates, where affordable domestic substitutes are often unavailable. Producers of specialty chemicals, heavily dependent on Chinese raw materials, are experiencing production disruptions. At the same time, fertilizer manufacturers are seeing profit margins eroded due to tariffs on phosphate imports. In response, companies are ramping up R&D into bio-based alternatives, forming procurement alliances to consolidate buying power, and shifting production to tariff-neutral nations such as Saudi Arabia.

The supercritical carbon dioxide (co₂) drying chemical market research report is one of a series of new reports that provides supercritical carbon dioxide (co₂) drying chemical market statistics, including supercritical carbon dioxide (co₂) drying chemical industry global market size, regional shares, competitors with a supercritical carbon dioxide (co₂) drying chemical market share, detailed supercritical carbon dioxide (co₂) drying chemical market segments, market trends and opportunities, and any further data you may need to thrive in the supercritical carbon dioxide (co₂) drying chemical industry. This supercritical carbon dioxide (co₂) drying chemical market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

Supercritical carbon dioxide (CO₂) drying chemical refers to a specialized formulation used to support drying processes by leveraging the unique characteristics of supercritical CO₂. It enables rapid and consistent moisture removal while maintaining the integrity of the material. The chemical functions under supercritical conditions to improve mass transfer efficiency and enhance overall drying performance. It also provides the added benefit of reducing thermal degradation due to its low-temperature operation.

The key components of supercritical carbon dioxide (CO₂) drying chemicals include equipment, solvents, additives, and others. Supercritical CO₂ drying chemical equipment refers to machinery engineered to use supercritical carbon dioxide as a solvent to effectively remove moisture or solvents from materials while preserving their structural and quality attributes. It is used in various applications such as pharmaceuticals, food and beverages, cosmetics and personal care, materials science, and others, and serves multiple end users, including research laboratories, industrial manufacturing, academic institutes, and other sectors.

The supercritical carbon dioxide (co₂) drying chemical market consists of sales of catalysts, stabilizers, co-processing agents, conditioning agents, and performance enhancers. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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