Histidine Tag (His-Tag) Antibody Global Market Report 2025

The histidine tag (His-Tag) antibody market size has grown rapidly in recent years. It will grow from $1.28 billion in 2024 to $1.43 billion in 2025 at a compound annual growth rate (CAGR) of 12%. The growth in the historic period can be attributed to rising demand for recombinant protein purification, increasing adoption of affinity chromatography, expanding applications in molecular biology research, growing use in biopharmaceutical production, and rising funding for life sciences research.

The histidine tag (His-Tag) antibody market size is expected to see rapid growth in the next few years. It will grow to $2.22 billion in 2029 at a compound annual growth rate (CAGR) of 11.6%. The growth in the forecast period can be attributed to rising demand for targeted therapeutics, increasing use of his tag antibodies in drug discovery, expanding biopharmaceutical manufacturing activities, growing investment in biotechnology research, and rising focus on personalized medicine. Major trends in the forecast period include technological advancements in antibody engineering, innovations in purification platforms, development of high affinity recombinant antibodies, research and development in molecular tagging methods, and automation in laboratory processes.

The rising demand for biopharmaceuticals is expected to propel the growth of the histidine tag His Tag antibody market going forward. Biopharmaceuticals refer to therapeutic products that are produced using biological sources or biotechnology methods rather than traditional chemical synthesis. The increasing demand for biopharmaceuticals is due to the rising prevalence of chronic and complex diseases, which drives the need for advanced targeted therapies that conventional drugs cannot effectively treat. Histidine tag His Tag antibodies support biopharmaceutical research by enabling precise detection and purification of recombinant proteins, making them essential for drug development and therapeutic protein production. They reduce experimental errors by providing high specificity and reproducibility, improving research efficiency and bioprocess reliability. For instance, in June 2025, according to the Centers for Medicare and Medicaid Services CMS, a US based federal agency, prescription drug outlays rose eleven point four percent in 2023 to four hundred forty nine point seven billion dollars, accelerating from seven point eight percent growth in 2022. Therefore, the rising demand for biopharmaceuticals is driving the growth of the histidine tag His Tag antibody market.

Major companies operating in the histidine tag His Tag antibody market are focusing on developing advanced products such as automated biosensor based His tag quantification kits to accelerate and standardize protein detection from crude and purified samples. Automated biosensor based His tag quantification kits refer to commercial assay kits that use biosensor technology to detect and measure His tagged proteins automatically. For instance, in November 2025, HexagonFab Limited trading as Abselion, a UK based life science tools company, launched the Tagged Protein Quantification Kit for His tag and the Tagged Protein Sensor for His tag quantification. It is built for the Amperia platform and developed with GenScript’s THE His Tag monoclonal antibodies. The automated biosensor based His tag quantification kit provides a rapid mix and read antibody free method for quantifying His tagged proteins directly in crude samples. When used with Abselion's Amperia biosensors, the system enables real time label free analysis, streamlining the protein characterization workflow without the need for multiple separate instruments. Its main purpose is to accelerate expression screening, bioprocess optimization, and quality control by providing dependable His tagged protein measurements without specialist training.

In December 2023, Danaher Corporation, a US based biotechnology company, acquired Abcam plc for five point seven billion dollars. With this acquisition, Danaher aims to strengthen its position in the life sciences and proteomics market, expanding its portfolio of research reagents, antibodies, and related solutions for drug discovery and diagnostics. Abcam plc is a UK based life sciences company that produces His Tag antibodies for detecting and purifying recombinant proteins.

Major companies operating in the histidine tag (his-tag) antibody market are Thermo Fisher Scientific Inc., Danaher Corporation, Merck KGaA, Bio-Rad Laboratories Inc., GeneTex Inc., Bio-Techne Corporation, GenScript Biotech Corporation, Sino Biological Inc., Cell Signaling Technology Inc., Wuhan Elabscience Biotechnology Co. Ltd., ABclonal Technology Co. Ltd., Proteintech Group Inc., Santa Cruz Biotechnology Inc., Rockland Immunochemicals Inc., Creative Diagnostics Inc., Aviva Systems Biology Corporation, Abnova Corporation, Boster Biological Technology Co. Ltd., Columbia Biosciences Corporation, NSJ Bioreagents

North America was the largest region in the histidine tag (His-Tag) antibody market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in histidine tag (His-Tag) antibody report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa. The countries covered in the histidine tag (His-Tag) antibody market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report’s Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The sudden escalation of U.S. tariffs and the consequent trade frictions in spring 2025 are severely impacting the healthcare sector, particularly in the supply of critical medical devices, diagnostic equipment, and pharmaceuticals. Hospitals and healthcare providers are facing higher costs for imported surgical instruments, imaging equipment, and consumables such as syringes and catheters, many of which have limited domestic alternatives. These increased costs are straining healthcare budgets, leading some providers to delay equipment upgrades or pass on expenses to patients. Additionally, tariffs on raw materials and components are disrupting the production of essential drugs and devices, causing supply chain bottlenecks. In response, the industry is diversifying sourcing strategies, boosting local manufacturing where possible, and advocating for tariff exemptions on life-saving medical products.

The histidine tag (His-Tag) antibody market research report is one of a series of new reports that provides histidine tag (His-Tag) antibody market statistics, including histidine tag (His-Tag) antibody industry global market size, regional shares, competitors with a histidine tag (His-Tag) antibody market share, detailed histidine tag (His-Tag) antibody market segments, market trends and opportunities, and any further data you may need to thrive in the histidine tag (His-Tag) antibody industry. This histidine tag (His-Tag) antibody market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

Histidine tag (His Tag) antibody is a specialized antibody that binds specifically to the histidine tag, a short sequence of histidine residues genetically added to recombinant proteins. It allows researchers to identify, isolate, and study His tagged proteins with high specificity and efficiency in molecular and biochemical experiments.

The main product types of histidine tag (His Tag) antibody are monoclonal antibodies, polyclonal antibodies, recombinant antibodies, nanobodies, and other product types. Monoclonal antibodies are highly specific antibodies produced from a single clone and are used for the precise detection of His tagged recombinant proteins. It is applied in western blotting, immunoprecipitation, flow cytometry, and others, supporting end users in pharmaceutical research and development, biotechnology, academic institutions, and contract research organizations.

The histidine tag (His-Tag) antibody market consists of sales of primary antibodies, secondary antibodies, antibody conjugates, antibody kits, and purification resins. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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