DNA SYNTHESIS MARKET: GROWTH AND TRENDS
The process of DNA synthesis involves creating deoxyribonucleic acid (DNA) molecules that are utilized in producing gene therapies and other therapeutic areas. The increasing trend of tailored treatments to address specific patient needs has heightened the demand for DNA or RNA molecules for numerous therapeutic purposes. DNA molecules are also essential in medical research, disease detection, analytical procedures, and forensic analysis. Numerous studies have taken place to assess the therapeutic application of oligonucleotides, especially DNA, for different medical issues. Moreover, the oligonucleotide molecules are now utilized in diagnosing genetic diseases, including cancer, ovarian cancer, dyslexia, psoriasis, and Parkinson's disease.Advanced technologies such as genetic modification, genome sequencing, gel electrophoresis, and recombinant DNA methods enable researchers to design precise oligonucleotides for medical progress. Numerous DNA-based treatments have been developed by pharmaceutical firms to aid in the management of different illnesses, thus contributing significantly towards the market.
It is important to highlight that numerous DNA synthesis companies are offering technologies and services to enhance the production of DNA molecules. Significantly, companies operating in this domain have developed unique enzymatic DNA synthesis systems that offer improved accessibility and convenience over DNA replication methods, in addition to extending the length of DNA strands. Due to the precision and management offered by high-throughput technologies, numerous researchers and developers of oligonucleotide-based therapies opt to outsource DNA replication and synthesis processes to external service providers with the required expertise.
Driven by the increasing demand for naturally or synthetically generated DNA, several industry leaders have shown a strong interest in this field to improve the efficiency, and precision of the DNA manufacturing process.
DNA SYNTHESIS MARKET: KEY INSIGHTS
The report delves into the current state of the DNA synthesis market and identifies potential growth opportunities within industry. Some key findings from the report include:
- Around 65 companies presently claim to have the required expertise for DNA synthesis technologies and affiliated services; of these, more than 50% of players are small companies and have recently been established.
- There has been a notable increase in the published scientific literature related to DNA synthesis technologies and services in the last few years; such articles have been published in over 50 countries.
- The growing interest in DNA synthesis technologies and services is reflected by the increase in partnership activity in the recent past; in fact, between 2019 and 2021, the partnership activity increased at a CAGR of 18%.
- Over the past few years, 150 academic grants have been awarded to various organizations in order to support the ongoing efforts related to research and innovation in the field of DNA synthesis technologies.
- Several investors, having realized the future opportunity associated with DNA synthesis technologies and services market, have invested more than USD 750 million in the past five years.
- More than 11,000 patents have been filed / granted related to DNA synthesis technologies Since 2016, establishing a strong portfolio of intellectual property within this industry.
- The DNA synthesis services market is expected to witness an annualized growth rate of more than 22% till 2035; the opportunity is likely to be distributed across methods of synthesis applications, company sizes and geographies.
DNA SYNTHESIS MARKET: KEY SEGMENTS
Chemical Method Accounts for the Highest Share of DNA Synthesis Market
In terms of method of DNA synthesis, the market is segmented into chemical and enzymatic methods. Our estimates suggest that the chemical method accounts for the largest share of the market in the current year and is poised to hold 57% of the overall revenue share by 2035. Owing to the growing usage of enzymes for DNA isolation and synthesis, the enzymatic method is likely to grow at a higher CAGR of 21% during the forecast period.Research and Diagnostics Capture Most of the Market Share in the Current Year
In terms of key application areas, the global DNA synthesis market is distributed across research & diagnostics and therapeutic applications. It is worth noting that research & diagnostic applications are likely to hold 61% of the overall revenue share by 2035. Further, therapeutic applications are likely to grow at a higher CAGR during the forecast period, owing to the rising interest in nucleic acid-based therapies, gene therapy, and personalized treatment.Presently, Large Companies Occupy the Majority of the DNA Synthesis Market Share
In terms of company size, the DNA synthesis market has been distributed among small, mid-sized, and large companies. In the current year, large companies are estimated to hold majority of the overall revenue share. Further, small companies are expected to grow at a CAGR of 20.9% during the forecast period.Asia-Pacific is Likely to Grow at a Higher CAGR During the Forecast Period
In terms of geographical regions, the DNA synthesis market is segmented across North America, Europe, Asia-Pacific, and the rest of the world. North America currently accounts for the largest share of the market and is expected to hold 50% of the overall share of the market by 2035. In Asia-Pacific and the rest of the world, the market will grow at a higher CAGR of 21% during the forecast period.Example Players in the DNA Synthesis Market
- Ajinomoto Bio-Pharma Services
- ATUM
- DNA Script
- Eurofins Genomics
- Gene Universal
- GenScript
- Synbio Technologies
DNA SYNTHESIS MARKET: RESEARCH COVERAGE
- Market Sizing and Opportunity Analysis: The report features a thorough analysis of the global DNA synthesis market, in terms of the key market segments, including [A] method of DNA synthesis, [B] key application areas, [C] company size, [D] therapeutic area, [E] key geographical regions.
- Market Landscape: An in-depth assessment of the companies involved in DNA synthesis market, based on several relevant parameters, such as [A] year of establishment, [B] company size, [C] location of headquarters, [D] type of offering, [E] method of DNA synthesis [F] type of DNA molecule, [G] custom offerings, and [H] application area.
- Company Profiles: Detailed profiles of key service providers across North America, Europe and Asia-Pacific engaged in the DNA synthesis market, focused on parameters such as [A] company overview, [B] financial information (if available), [C] service portfolio, [D] manufacturing facilities and [E] recent developments and an informed future outlook.
- Case Study 1: A case study providing a detailed overview of the current market landscape of oligonucleotide manufacturers focused on research and diagnostic applications, based on several relevant parameters, such as [A] year of establishment, [B] company size, [C] scale of operation, [D] location of headquarters, [E] number of manufacturing facilities, [F] location of facility, [G] regulatory accreditations and certifications received, [H] type of oligonucleotide manufactured, [I] type of offering, [J] type of manufacturing service(s) offered and [K] type of modification(s) offered.
- Case Study 2: A case study featuring a detailed overview of the current market landscape of oligonucleotide manufacturers focused on therapeutic applications, based on several relevant parameters, such as [A] year of establishment, [B] company size, [C] scale of operation, [D]location of headquarters, [E] number of manufacturing facilities, along with information [F] location of facility, [G] regulatory accreditations and certifications received, [H] type of oligonucleotide manufactured, [I] type of offering, [J] type of manufacturing service(s) offered.
- Partnerships and Collaborations: An in-depth analysis of the partnership’s activity reported in this domain, based on parameters such as [A] year of partnership, [B] type of partnership [C] scale of operation, and [D] type of partner company.
- Funding and Investment Analysis: A detailed analysis of funding and investments made in the domain, including [A] seed financing, [B] venture capital financing, [C] debt financing, [D] grants, [E] capital raised from IPOs and [F] subsequent offerings, at various stages of development.
- Grant Analysis: An in-depth analysis of grants that have been awarded to various research institutes for projects related to DNA synthesis technologies and services, Since 2017, on the basis of important parameters, such as [A] year of grant award, [B] grant amount awarded, [C] administering institute center, [D] support period, [E] type of grant application, [F] grant activity code, [G] emerging focus area, [H] purpose of grant award, [I] type of recent organization, popular NIH department and [J] prominent program officers.
- Publication Analysis: A detailed review of more than 12,000 peer-reviewed, scientific articles related to research on DNA synthesis technologies, which have been published Since 2017, including analysis based on parameters, such as [D] year of publication, [D] key focus area, [D] type of article, [D] popular keywords, [D] popular authors, [D] therapeutic area, geography and key journals (in terms of number of articles published in this domain and impact factor of the journal).
- Patent Analysis: An overview of the various patents that have been filed / granted, based on various parameters, such as publication year, geography, [D] CPC symbols, emerging focus areas, [D] type of applicant and [D] leading industry players.
KEY QUESTIONS ANSWERED IN THIS REPORT
- How many companies are currently engaged in this market?
- Which are the leading companies in this market?
- What factors are likely to influence the evolution of this market?
- What is the current and future market size?
- What is the CAGR of this market?
- How is the current and future market opportunity likely to be distributed across key market segments?
REASONS TO BUY THIS REPORT
- The report provides a comprehensive market analysis, offering detailed revenue projections of the overall market and its specific sub-segments. This information is valuable to both established market leaders and emerging entrants.
- Stakeholders can leverage the report to gain a deeper understanding of the competitive dynamics within the market. By analyzing the competitive landscape, businesses can make informed decisions to optimize their market positioning and develop effective go-to-market strategies.
- The report offers stakeholders a comprehensive overview of the market, including key drivers, barriers, opportunities, and challenges. This information empowers stakeholders to stay abreast of market trends and make data-driven decisions to capitalize on growth prospects.
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Table of Contents
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- Ajinomoto Bio-Pharma Services
- Aldevron
- AltaBioscience
- Ansa Biotechnologies
- Arbor Biosciences
- ATUM
- Beijing SBS
- Bio Basic
- Biolegio
- Biomatik
- Bioneer
- Biosearch Technologies
- Bio-Synthesis
- Blue Heron Biotech
- BOC Sciences
- BR Biochem Life Sciences
- Camena Bioscience
- Catalog
- ChemGenes Corporation
- Creative Biogene
- CustomArray
- CyberGene
- Dalton Pharma Services
- DNA Script
- Eton Bioscience (Subsidiary of Codex DNA)
- Eurofins Genomics
- Eurogentec
- Evonetix
- Futuresynthesis
- Gene Universal
- General Biosystems
- Generi Biotech
- Genewiz
- GenScript
- Glen Research
- Helixworks Technologies
- IBA Lifesciences
- Integrated DNA Technologies
- Iridia
- KareBay Biochem
- Kern Systems
- Kilobaser
- LC Sciences
- metabion
- Microsoft
- Microsynth
- Midland Certified Reagent Company
- Molecular Assemblies
- Moligo Technologies
- Nitto Denko Avecia
- Nuclera Nucleics
- Oligomer Biotechnology
- Origene
- ProMab Biotechnologies
- ProteoGenix
- Quintaribio
- Ribbon Biolabs
- SARTOMED
- Sigma-Aldrich (Acquired by Merck)
- Sunomix Biosciences
- Synbio Technologies
- Syngene
- SynHelix
- Synthomics
- TAG Copenhagen
- Thermo Fisher Scientific
- Xcelris Labs
- Yale School of Medicine
- GE Research
- Baseclick
- French Ministry for Armed Forces
- Dynamic Combinatorial Chemistry (DCC)
- Bright Peak Therapeutics
- Trio Pharmaceuticals
- GeneDesign
- BIOfidal
- Transcenta
- Amptec
- Eton Bioscience
- Glen Research Corporation
- CodexisCodexis
- TeselaGen Biotechnology
- Analog Devices
- imec
- LioniX International
- PeproTech
- Patheon
- GSL Biotech
- Twist Bioscience
- Horizon Discovery
- CustomArray
- Blue Heron Biotech
- SynHelix
- Isolere Bio
- Aldevron
- Biotechnolabs
- iGEM
- Integrated DNA Technologies
- GENEWIZ
- Eurofins Genomics
- Kazusa DNA Research Institute
- GeneBay
- Aldevron
- Agilent Technologies
- Illumina Ventures
- Sofinnova Partners
- Kurma Partners
- Casdin Capital
- Danaher Life Sciences
- M Ventures
- Columbia Threadneedle Investments
- Casdin Capital
- Alexandria Venture Investments
- iSelect Fund
- Codexis
- Argonautic Ventures
- Horizons Ventures
- Mubadala Capital
- Humboldt Fund
- National Science Foundation
- Civilization Ventures
- Illumina Ventures
- Merck Ventures
- Idinvest Partners
- Bpifrance
- Bpifrance
- Life Sciences Partners
- M. Ventures
- Kurma Partners and Idinvest Partners
- Bpifrance
- Merck
- Life Sciences Partners
- Bpifrance
- Life Science Partners
- Bpifrance Large Venture Fund
- Alexandria Venture
- Fidelity Management and Research
- Arrowmark Partners
- Farallon Capital
- Moore Strategic Ventures
- National Human Genome Research Institute
- Coatue Management
- Catalio Capital Management
- Fidelity Management & Research Company
- eureKARE
- Irving Investors
- IST Cube
- tecnet equity
- Hadean Ventures
- Lansdowne Partners
- Helicase Venture
- IST cube
- tecnet equity
- iSelect Fund
- Keshif Ventures
- Agilent Technologies
- LYFE Capital
- National Human Genome Research Institute
- SynBio Innovation Accelerator
- LYFE Capital
- DCVC
- Rising Tide
- Providence Investment Company Limited
- Molten Ventures
- Cambridge Consultants
- Innovate UK
- Draper Esprit
- DCVC (Data Collective)
- The Morningside group
- Providence Investment Company
- Cambridge Consultants
- Rising Tide Fund
- Tech Coast Angels
- The Department of Air Force
- Department of Health and Human Services
- TEEC Angel Fund
- TA Associates
- Colibri Ventures
- Vanderbilt University
- Division of Basic Sciences
- Columbia University Health Sciences
- Medical College of Wisconsin
- Eunice Kennedy Shriver National Institute of Child Health & Human Development
- Univ Of North Carolina Chapel Hill
- Weill Medical Coll of Cornell Univ
- University of Minnesota
- University of Iowa
- National Institute on Aging
- National Institute of Environmental Health Sciences
- University of Wisconsin-Madison
- Life Technologies
- Tosoh
- Achillion Pharmaceuticals
- Harvard College
- Broad Institute
Methodology

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