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Castration-sensitive Prostate Cancer - Market Insights, Epidemiology, and Market Forecast - 2036

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    Report

  • 200 Pages
  • February 2026
  • Region: Global
  • DelveInsight
  • ID: 6219882

Key Highlights

  • The Castration-sensitive Prostate Cancer Market in the 7MM was valued at approximately USD 5.14 billion in 2025 over the forecast period from 2026 to 2036.
  • The Castration-sensitive Prostate Cancer Market is projected to grow at a CAGR of 10% by 2036 in the leading countries (the US, EU4, UK, and Japan)

Castration Sensitive Prostate Cancer Market and Epidemiology Analysis

  • The CSPC Market is expected to witness significant growth owing to the rising prevalence of prostate cancer cases due to the rapidly aging population and growing disease awareness among people. In addition, extensive market penetration of approved therapies in CSPC due to label expansions and the entry of new emerging therapies will be crucial factors facilitating the market growth.
  • CSPC market remained a dry space since a long time, however since the approval and usage of ZYTIGA in 2017, followed by XTANDI in 2019, ERLEADA in 2020, NUBEQA and ORGOVYX in 2022, the metastatic segment of CSPC witnessed a significant growth.
  • Within overall prostate cancer cases, CSPC (both metastatic and non-metastatic) is the major contributor in terms of patient size and volume, however the more aggressive type, CRPC has been leading with multiple approvals in its bucket during last decade due to its aggressive nature, unmet need and broader commercial opportunity.
  • Improved screening and awareness are leading to earlier diagnosis, keeping more patients in the CSPC stage for longer periods before progression.
  • Real-world CSPC treatment patterns vary widely due to differences in geography, physician practices, access to therapy, and patient characteristics, often resulting in underuse of intensified regimens despite guideline recommendations.
  • The non-metastatic CSPC (nmCSPC) space was previously unaddressed, with ADT or surveillance as the only options. XTANDI’s 2023 approval alongside leuprolide marks the first major breakthrough, bringing a targeted anti-androgen approach to this underserved population.
  • XTANDI is currently the only approved therapy for nmCSPC with high-risk biochemical recurrence (BCR). In the pipeline, NUBEQA + ADT and MVI-816 + Nivolumab are being investigated as potential alternatives in this setting.
  • ZYTIGA’s revenue has plateaued due to the entry of generics. XTANDI and ERLEADA dominates the current market, with NUBEQA and ORGOVYX further strengthening the competitive landscape.
  • Approval of ERLEADA for mCSPC has put a barrier to the growth of the sales of ZYTIGA, which is already facing competition. After the launch of generic versions in the Q4 of 2019, ZYTIGA’s sales in the US dropped by 59% to USD 198 million in the second quarter.
  • Radioligand therapies (e.g., PLUVICTO) and PARP inhibitors (e.g., TALZENNA) are advancing from mCRPC to mCSPC, with approvals expected in 2026.
  • The leading Castration Sensitive Prostate Cancer Companies, such as AstraZeneca, Tavanta Therapeutics, Janssen/Merck/Tesaro, Johnson & Johnson, Bayer/Orion, and others, are investigating their key products for managing mCSPC.
  • Eli Lilly and Merck faced setbacks in prostate cancer trials. Lilly ended the CYCLONE-3 trial of VERZENIO plus ZYTIGA in mHSPC due to futility, while Merck discontinued the KEYNOTE-991 trial after interim analysis. Highlighting ongoing challenges in advancing new therapies for mHSPC.

Castration Sensitive Prostate Cancer Market Size and Forecast

  • 2025 Castration Sensitive Prostate Cancer Market Size: USD 5.14 billion
  • 2036 Projected Castration Sensitive Prostate Cancer Market Size: USD 11.75 billion
  • Castration Sensitive Prostate Cancer Growth Rate (2026-2036): 10% CAGR
  • Largest Castration Sensitive Prostate Cancer Market: United States

Key Factors Driving the Growth of the Castration-sensitive Prostate Cancer Market

  • Rising prostate cancer incidence and ageing populations
Prostate cancer incidence is strongly associated with age, most frequently diagnosed in men between 65 and 74 years. However, age-specific patterns vary across regions, with the lowest prevalence observed in individuals over 84 years in the US, while in Japan, cases are least common among men aged 54 years or younger. Overall, prostate cancer risk rises with advancing age, and ongoing global demographic shifts toward older populations are expanding the diagnosed patient pool, thereby increasing the addressable market for CSPC therapies and diagnostics.
  • Competitive Dynamics in the CSPC Market
XTANDI and ERLEADA lead the CSPC market with broad adoption and clinical validation, while newer entrants like NUBEQA and ORGOVYX are gaining ground, enhancing competition with differentiated benefits and expanding CSPC market share.
  • Advances in Mutation-Targeted CSPC Therapies
The development of therapies targeting specific mutations is expected to perform better in the future, such as AKEEGA (HRR gene-mutated mCSPC), TALZENNA (DDR-deficient mCSPC), TRUQAP (de novo PTEN-deficient mHSPC), and others.
  • Radioligand and PARP Inhibitors Driving Future CSPC Market Growth
The emergence of radioligand and PARP inhibitor therapies in CSPC makes it a lucrative market in the future. Johnson & Johnson, the first to demonstrate the benefits of the PARP + androgen receptor pathways combo (niraparib + abiraterone) in HRR-mutated mCSPC, may gain an early-mover advantage in precision CSPC.

The “Castration-sensitive Prostate Cancer Treatment Market Insights, Epidemiology, and Market Forecast - 2036” report delivers an in-depth understanding of the Castration-sensitive Prostate Cancer, historical and forecasted epidemiology as well as the Castration-sensitive Prostate Cancer Market Trends in the United States, EU4 (Germany, Spain, Italy, and France) and the United Kingdom, and Japan.

The Castration-sensitive Prostate Cancer Treatment Market Report provides real-world prescription pattern analysis, emerging drugs, market share of individual therapies, and historical and forecasted 7MM Castration-sensitive Prostate Cancer market size from 2022 to 2036. The report also covers current Castration-sensitive Prostate Cancer treatment practices/algorithms and unmet medical needs to curate the best opportunities and assess the market’s potential.

Castration Sensitive Prostate Cancer Disease Understanding

Castration Sensitive Prostate Cancer Overview

Prostate cancer is a common malignancy that develops in the prostate gland and primarily affects men. It typically grows slowly and often remains confined to the prostate in its early stages, where it may not cause significant harm. Advanced stages of the disease include metastatic castration-sensitive prostate cancer (mCSPC) - also known as metastatic hormone-sensitive prostate cancer (mHSPC). This form is characterized by cancer that has spread beyond the prostate to other parts of the body but still responds to hormone (androgen deprivation) therapy. Based on imaging, metastatic prostate cancer is further classified into:

M0 CSPC: No visible metastases on conventional imaging.

M1 CSPC: Confirmed metastases present.

Differentiating M0 CSPC from local recurrence after curative treatment can be challenging. In such cases, histology and PSA (prostate-specific antigen) levels play a key role in diagnosis. While, nmCSPC refers to prostate cancer confined to the pelvis with no evidence of distant spread on imaging, but still responds to hormone-lowering therapy.

Castration Sensitive Prostate Cancer Diagnosis

Advanced cancer can be detected before, simultaneously with, or after the primary tumor. Most individuals diagnosed with advanced prostate cancer have previously undergone a biopsy and some form of treatment. When a new tumor appears in someone with a prior cancer history, it often indicates that the cancer has spread. Initial assessment typically includes PSA testing, a digital rectal examination (DRE), prostate biopsy, and imaging studies such as MRI, CT scans, or bone scans to determine the extent of disease. Based on imaging results, castration-sensitive prostate cancer (CSPC) is classified as either non-metastatic (M0) or metastatic (M1). Distinguishing between local recurrence and metastatic disease can sometimes be difficult, with histological evaluation and PSA trends providing critical diagnostic information. Precise diagnosis and staging at this stage are vital, as they guide treatment decisions - from potentially curative therapies for localized disease to systemic approaches for metastatic cases.

Castration Sensitive Prostate Cancer Treatment

The management of nmCSPC has undergone considerable evolution. In the past, treatment options were largely limited to androgen deprivation therapy (ADT) or observation, particularly for patients experiencing high-risk biochemical recurrence following primary therapy. As insights into disease progression advanced, interventions such as salvage radiotherapy emerged as first-line options. The 2023 approval of XTANDI represented a major milestone, introducing the first targeted anti-androgen therapy specifically for nmCSPC with high-risk biochemical recurrence. This approval established a new standard of care, allowing for earlier and more effective treatment.

In the metastatic hormone-sensitive prostate cancer (mHSPC) setting, several systemic therapies have become available. While ADT remains the cornerstone of treatment, adding docetaxel chemotherapy or second-generation antiandrogens - such as abiraterone, apalutamide, and enzalutamide - has shown survival benefits. The growing range of therapeutic options has broadened treatment possibilities but also poses a challenge for clinicians in determining the most suitable agent for treatment intensification for each patient.

Castration Sensitive Prostate Cancer Epidemiology

The epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by Total Prevalent cases of Prostate cancer, Five-year Prevalent cases of Prostate cancer, Age-specific cases of Prostate cancer, Total cases of Prostate cancer by clinical stages, Five-year Prevalent cases of CSPC, Total Prevalent cases of mCSPC and nmCSPC in the 7MM covering the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan from 2022 to 2036.

Castration Sensitive Prostate Cancer Epidemiological Analysis and Forecast

  • Widespread PSA screening, earlier detection, aging populations, and improved cancer registry coverage are all fueling the rise in prostate cancer cases across the 7MM. In 2024, the 7MM had approximately 7.5 million prevalent cases of prostate cancer. These are expected to rise during the forecast period (2026-2036).
  • As per the estimates, prostate cancer commonly occur in people aged 65-74 years.
  • As per the estimates, in the US, majority of the cases were found to be localized/locally advanced cases (Stage I-III), comprising approximately 56% of total cases, while nearly 33% belonged to biochemical recurrence/ progressive cases, and ~11% belonged to metastatic cases.
  • The five-year prevalent cases of CSPC in the US comprised was about more than 300,000 cases in 2024 and are projected to increase during the forecast period.
  • In Japan, during 2024, mCSPC cases made up approximately 21% of the total prevalent cases of CSPC.

Castration Sensitive Prostate Cancer Epidemiology Segmentation

  • Total Prevalent cases of Prostate cancer
  • Five-year Prevalent cases of Prostate cancer
  • Total cases of Prostate cancer by clinical stages
  • Five-year Prevalent cases of CSPC
  • Total Prevalent cases of nmCSPC and mCSPC
  • Age-specific cases of Prostate cancer

Castration Sensitive Prostate Cancer Drug Analysis

The drug chapter segment of the Castration Sensitive Prostate Cancer Therapeutics Market Report encloses a detailed analysis of marketed and emerging drugs of late-stage (Phase III and Phase II) Castration Sensitive Prostate Cancer pipeline drugs. It also deep dives into the CSPC pivotal clinical trial details, recent and expected market approvals, patent details, the latest news, and recent deals and collaborations. XTANDI and ERLEADA lead the CSPC market with broad adoption and clinical validation, while newer entrants like NUBEQA and ORGOVYX are gaining ground, enhancing competition with differentiated benefits and expanding market share.

Castration Sensitive Prostate Cancer Marketed Drugs

  • NUBEQA (darolutamide): Bayer and Orion Corporation
NUBEQA is an oral androgen receptor inhibitor (ARI) with a distinct chemical structure that binds strongly to the androgen receptor, effectively blocking its activity and suppressing the growth of prostate cancer cells. Preclinical studies and neuroimaging in healthy volunteers indicate that darolutamide has minimal potential to cross the blood-brain barrier. Developed collaboratively by Bayer and Orion Corporation, NUBEQA is approved for use in adults with metastatic castration-sensitive prostate cancer (mCSPC) in combination with docetaxel.

In April 2025, Bayer shared new findings on NUBEQA at the AUA Annual Meeting. Key updates included post-hoc analyses from the Phase III ARANOTE trial showing that ultra-low PSA responses are associated with improved outcomes in metastatic hormone-sensitive prostate cancer (mHSPC), long-term safety results from the ARASENS Rollover trial, and progress from the ongoing ARASTEP trial in patients with high-risk biochemical recurrence.
  • XTANDI (enzalutamide): Astellas Pharma/Pfizer
XTANDI is an inhibitor of androgen receptor signaling. Enzalutamide, recognized as a standard of care, has obtained regulatory approval in multiple countries for treating men with mHSPC and nmHSPC who are at high risk of BCR. The expanded approval of XTANDI is supported by findings from the Phase III EMBARK trial in men with high-risk BCR nmHSPC. In April 2024, the European Association of Urology (EAU) updated its treatment guidelines to recommend enzalutamide for men with high-risk BCR nmHSPC, either with or without ADT, following radiation therapy or surgery.

According to Pfizer’s Q1 2025 SEC filing, starting in August 2024, the company filed patent infringement lawsuits against generic drug applicants in the US District Court for the District of New Jersey, asserting both the validity and infringement of the relevant patents.

Castration Sensitive Prostate Cancer Emerging Drugs

  • TRUQAP (capivasertib, AZD 5363): AstraZeneca
TRUQAP is a novel pyrrolopyrimidine compound that functions as an orally administered inhibitor of the serine/threonine kinase AKT (protein kinase B), showing potential anticancer effects. The company has completed Phase Ib and Phase I/II trials of capivasertib for prostate cancer. Additionally, AstraZeneca is evaluating capivasertib in combination with ZYTIGA in the Phase III CAPItello-281 study for metastatic hormone-sensitive prostate cancer (mHSPC) and in the CAPItello-280 study alongside docetaxel for metastatic castration-resistant prostate cancer (mCRPC).
  • Saruparib (AZD5305): AstraZeneca
AZD5305 is a highly potent and selective oral PARP inhibitor (PARPi) that primarily targets and traps PARP1, unlike currently approved PARPis, which inhibit both PARP1 and PARP2. Preclinical studies indicate that inhibiting PARP1 produces antiproliferative effects, whereas PARP2 inhibition is largely responsible for hematological toxicities. This suggests that AZD5305 could offer a better therapeutic index with reduced toxicity. The drug is currently in Phase III development for both HRRm and non-HRRm metastatic castration-sensitive prostate cancer (mCSPC). According to AstraZeneca’s Q1 2025 clinical trial appendix, results from the saruparib Phase III trial (EvoPAR-Prostate01/NCT06120491) and Phase I/IIa trial (PETRANHA/NCT05367440) are expected after 2026.

Castration Sensitive Prostate Cancer Drug Class Insights

The current treatment landscape offers a wide array of therapeutic options, including androgen receptor inhibitors, CYP17 inhibitors, PARP inhibitors, AKT inhibitors, PSMA-targeted radioligand therapy, GnRH receptor antagonists, and other agents across different lines of therapy.

Androgen receptor pathway inhibitors remain a cornerstone for patients with CSPC. In the United States, four such inhibitors are approved: three anti-androgens - ERLEADA, XTANDI, and NUBEQA. CYP17 inhibitors, such as ZYTIGA, work by limiting androgen production that drives tumor growth. GnRH receptor antagonists (e.g., ORGOYVX) offer a newer method of androgen deprivation, rapidly reducing LH and testosterone levels without the initial surge associated with LHRH agonists.

Beyond hormone-based therapies, PARP inhibitors (e.g., saruparib, TALZENNA) have shown promise, particularly in patients with HRR gene mutations such as BRCA. Another innovative strategy is PSMA-targeted radioligand therapy, which delivers radiation specifically to PSMA-expressing cells using agents like [^177Lu] Lu-PSMA-617. While currently approved for mCRPC, research is exploring its use in earlier disease stages, including mCSPC.

Overall, these varied therapeutic classes illustrate a shift toward mechanism-based and biomarker-guided strategies in CSPC, combining hormonal therapies with targeted and precision approaches to enhance outcomes in both non-metastatic and metastatic settings.

Castration Sensitive Prostate Cancer Market Outlook

mCSPC, also known as mHSPC, is an advanced stage of prostate cancer in which the disease has metastasized but remains responsive to hormone therapy. Over the past twenty years, the treatment landscape for mCSPC has evolved significantly. Therapy has shifted from relying solely on ADT to more intensive approaches, including doublet regimens with ZYTIGA, ERLEADA, or XTANDI; triplet regimens combining docetaxel with ZYTIGA or NUBEQA; and ADT plus external beam radiotherapy (EBRT) for patients with low metastatic burden. ADT monotherapy is now generally discouraged except when combination therapy is contraindicated. Ongoing research and clinical trials are expected to further refine optimal treatment strategies, ultimately enhancing outcomes and quality of life for patients with mCSPC.

In contrast, nmHSPC or nmCSPC refers to prostate cancer that has not yet spread to distant sites detectable via standard imaging techniques such as CT or MRI, and the disease remains sensitive to testosterone-lowering therapies. Until 2023, nmCSPC had no approved treatment options. Standard management had been ADT or active surveillance, but the approval of the anti-androgen XTANDI in combination with leuprolide marked a major advancement.

In 2023, XTANDI became the first therapy in the US approved for nmCSPC with high-risk biochemical recurrence (BCR), based on the EMBARK trial, which demonstrated a statistically significant improvement in metastasis-free survival (MFS) for XTANDI plus leuprolide compared to placebo plus leuprolide.

XTANDI has experienced strong global sales growth in recent years, driven by its proven efficacy across multiple prostate cancer stages, including mHSPC, and its expansion into combination therapy settings. Astellas reported a 21.6% year-over-year revenue increase from 2023 to 2024, with growth across all regions. However, the company anticipates a 4.9% decline in future sales due to expected loss of exclusivity in Europe and Japan in 2026 and in the US in 2027.
  • The total market size of CSPC in the United States was approximately USD 2.58 billion in 2024 and is projected to increase during the forecast period (2026-2036).
  • In 2024, XTANDI accounted for the majority of the market share i.e. ~USD 630 million in the United States.
  • As per DelveInsight’s analysis, by 2036, among the therapies, the highest revenue is expected to be generated by NUBEQA in the EU4 and the UK.

Castration Sensitive Prostate Cancer Drugs Uptake

This section focuses on the uptake rate of potential Castration prostate Cancer drugs expected to be launched in the market during 2026-2036, which depends on the competitive landscape, safety, efficacy data, and order of entry. It is important to understand that the key players evaluating their novel therapies in the pivotal and confirmatory trials should remain vigilant when selecting appropriate comparators to stand the greatest chance of a positive opinion from regulatory bodies, leading to approval, smooth launch, and rapid uptake.

NUBEQA has shown consistent, nearly doubled quarter-on-quarter growth, and in recent quarters reached all-time high revenue levels, reflecting its accelerating uptake globally. ERLEADA appears to deliver the strongest real-world survival and PSA response advantage, followed by XTANDI and then ZYTIGA. However, uptake in clinical practice lags behind evidence.

Castration Sensitive Prostate Cancer Pipeline Development Activities

The report provides insights into therapeutic candidates in Phase III and II. It also analyzes key players involved in developing targeted therapeutics. The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for CSPC emerging therapies.

Latest KOL Views on Castration Sensitive Prostate Cancer

To keep up with the real-world scenario in current and emerging market trends, we take opinions from Key Industry leaders working in the domain through primary research to fill the data gaps and validate our secondary research. Industry Experts contacted for insights on the evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, and drug uptake along with challenges related to accessibility, including Medical/scientific Writers, Professors, and others.

The analysts connected with 20+ KOLs to gather insights; however, interviews were conducted with 18+ KOLs in the 7MM. Centers such as Emory University School of Medicine, Anderson Cancer Center, Southwestern Medical Center etc. were contacted. Their opinion helps understand and validate current and emerging therapy treatment patterns or Castration Sensitive Prostate Cancer market trends.

Castration Sensitive Prostate Cancer Report Qualitative Analysis

We perform qualitative and market Intelligence analysis using various approaches, such as SWOT and Conjoint analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of gaps in disease diagnosis, patient awareness, physician acceptability, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. Conjoint Analysis analyzes multiple approved and emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, designation, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

In efficacy, the trial’s primary and secondary outcome measures are evaluated; for instance, in trials for CSPC, one of the most important primary endpoints was achieving Percentage of Participants Achieving an Objective Response That Lasts at Least 4 Months (ORR4), Progression-Free Survival (PFS), Plaque Lesion Response Rates With Extended Treatment (Cycle 1 and 2 SGX301 vs Cycle 1 Placebo), and others. Based on these, the overall efficacy is evaluated.

Further, the therapies’ safety is evaluated, wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the route of administration, order of entry and designation, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Castration Sensitive Prostate Cancer Market Access and Reimbursement

Reimbursement is a crucial factor that affects the drug’s access to the market. Often, the decision to reimburse comes down to the price of the drug relative to the benefit it produces in treated patients. To reduce the healthcare burden of these high-cost therapies, many payment models are being considered by payers and other industry insiders. In August 2024, Accord Healthcare announced that the NICE had published its final guidance recommending ORGOVYX for the treatment of HSPC, recognizing the treatment as cost-effective in England. The recommendation offers patients the choice to receive an oral preparation of an ADT for the first time

XTANDI combined with ADT, is a first-line option in treating patients with mHSPC. In February 2023, HAS gave an opinion in favor of reimbursement in the treatment of mHSPC in adult men in association with ADT.

Conference Highlights

  • In June 2025, Johnson & Johnson Innovative Medicine presented late-breaking data from the Phase III AMPLITUDE (Oral Abstract: LBA5006) trial evaluating AKEEGA plus prednisone for patients with mCSPC and alterations in homologous recombination repair genes at the American Society of Clinical Oncology (ASCO), 2025 in Chicago.
  • In June 2025, Astellas Pharma presented new clinical insights at ASCO 2025 across its approved cancer therapies. Key highlights included post hoc analyses from the EMBARK trial evaluating secondary outcomes in high-risk biochemically recurrent prostate cancer patients treated with enzalutamide alone (#5103) or in combination with leuprolide (#e17127), as well as a separate study on corticosteroid use and associated adverse events in mHSPC patients (#e17097).
  • In April 2025, real-world, head-to-head study data from TITAN evaluating ERLEADA versus XTANDI in patients with mCSPC were presented at the 50th Annual Oncology Nursing Society (ONS) Congress.
  • In April 2025, Bayer presented new data on NUBEQA at the American Urological Association (AUA) Annual Meeting, reinforcing its potential as a treatment option across the prostate cancer disease spectrum and in diverse patient populations. Key presentations included post-hoc analyses from the Phase III ARANOTE trial, highlighting the significance of ultra-low PSA responses (< 0.02 ng/mL) and their correlation with improved clinical outcomes in patients with mHSPC treated with NUBEQA plus ADT.

Scope of the Castration Sensitive Prostate Cancer Market Report

  • The Castration Sensitive Prostate Cancer Therapeutics Market Report covers a segment of key events, an executive summary, and a descriptive overview of CSPC, explaining its causes, signs and symptoms, and currently available therapies.
  • Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential, disease progression, and treatment guidelines.
  • Additionally, an all-inclusive account of the current and emerging therapies, along with the elaborative profiles of late-stage and prominent therapies, will impact the current treatment landscape.
  • A detailed review of the castration-sensitive prostate cancer market, historical and forecasted market size, market share by therapies, detailed assumptions, and rationale behind our approach is included in the report, covering the 7MM drug outreach.
  • The Castration Sensitive Prostate Cancer Therapeutics Market Report provides an edge while developing business strategies by understanding trends through SWOT analysis and expert insights/KOL views, patient journey, and treatment preferences that help shape and drive the 7MM castration-sensitive prostate cancer.

Castration Sensitive Prostate Cancer Market Report Insights

  • Patient-based Castration Sensitive Prostate Cancer Market Forecasting
  • Therapeutic Approaches
  • CSPC Pipeline Analysis
  • CSPC Market Size and Trends
  • Existing and future Market Opportunity

Castration Sensitive Prostate Cancer Market Report Key Strengths

  • 11 Years Castration Sensitive Prostate Cancer Market Forecast
  • The 7MM Coverage
  • CSPC Epidemiology Segmentation
  • Key Cross Competition
  • Conjoint analysis
  • Castration Sensitive Prostate Cancer Drugs Uptake
  • Key Castration Sensitive Prostate Cancer Market Forecast Assumptions

Castration Sensitive Prostate Cancer Market Report Assessment

  • Current Castration Sensitive Prostate Cancer Treatment Practices
  • Castration Sensitive Prostate Cancer Unmet Needs
  • Castration Sensitive Prostate Cancer Pipeline Drugs Profiles
  • Castration Sensitive Prostate Cancer Drugs Market Attractiveness
  • Qualitative Analysis (SWOT and Conjoint Analysis)

Key Questions Answered in the Castration Sensitive Prostate Cancer Market Report

Castration Sensitive Prostate Cancer Market Insights

  • What is the historical and forecasted castration-sensitive prostate cancer patient pool in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan?
  • What was the total CSPC market size, the market size by therapies, market share (%) distribution in 2025, and what would it look like in 2036? What are the contributing factors for this growth?
  • What are the pricing variations among different geographies for approved and off-label therapies?
  • How would the market drivers, barriers, and future opportunities affect the market dynamics and subsequent analysis of the associated trends?
  • What are the current and emerging options for treating CSPC?
  • How many companies are developing therapies to treat CSPC?
  • What are the recent novel therapies, targets, mechanisms of action, and technologies developed to overcome the limitations of existing therapies?
  • Patient acceptability in terms of preferred treatment options as per real-world scenarios?
  • What are the country-specific accessibility issues of expensive, recently approved therapies?

Reasons to Buy the Castration Sensitive Prostate Cancer Market Report

  • The Castration Sensitive Prostate Cancer Therapeutics Market Report will help develop business strategies by understanding the latest trends and changing treatment dynamics driving the CSPC Market.
  • Insights on patient burden/disease, Castration Sensitive Prostate Cancer Prevalence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years
  • Understand the existing market opportunities in varying geographies and the growth potential over the coming years.
  • Distribution of historical and current patient share based on real-world prescription data along with reported sales of approved products in the US, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.
  • Identifying strong upcoming players in the market will help devise strategies to help get ahead of competitors.
  • Highlights of access and reimbursement policies of approved therapies, barriers to accessibility of expensive off-label therapies, and patient assistance programs.
  • To understand Key Opinion Leaders’ perspectives around the accessibility, acceptability, and compliance-related challenges of existing treatment to overcome barriers in the future.
  • Detailed insights on the unmet needs of the existing market so that the upcoming players can strengthen their development and launch strategy.

This product will be updated with the latest data at the time of order. Consequently, dispatch time for this product will be 7-10 business days.

Table of Contents

1. Key Insights2. Report Introduction3. Executive Summary of CSPC4. Key Events5. Epidemiology and Market Forecast Methodology
6. CSPC Market Overview at a Glance
6.1. Market Share of CSPC by Class (%) in 2025 in the 7MM
6.2. Market Share of CSPC by Class (%) in 2036 in the 7MM
6.3. Market Share of CSPC by Therapies (%) in the 7MM in 2025
6.3.1.1. Market Share of nmCSPC by Therapies (%)
6.3.1.2. Market Share of mCSPC by Therapies (%)
6.4. Market Share of CSPC by Therapies (%) in the 7MM in 2036
6.4.1.1. Market Share of nmCSPC by Therapies (%)
6.4.1.2. Market Share of mCSPC by Therapies (%)
7. Disease Background and Overview
7.1. Signs and Symptoms of Prostate Cancer
7.2. Grading and Staging
7.3. Risk Factors and Causes of Prostate Cancer
7.4. Biochemical Recurrence
7.5. Diagnosis
8. Treatment and Management
8.1. Impact of PSMA PET on Prostate Cancer Management
8.2. Guidelines
8.2.1. National Comprehensive Cancer Network Guidelines for Prostate Cancer (NCCN) (2025)
8.2.2. Updates to Advanced Prostate Cancer: American Urology Association/Society of Urologic Oncology Guideline (2023)
8.2.3. Recommendations From the US Prostate Cancer Conference (USPCC) (2024)
8.2.4. European Association of Urology Guidelines for mHSPC (2025)
8.2.5. European Society for Medical Oncology (ESMO) Treatment Recommendations for Prostate Cancer
8.2.6. National Institute for Health and Care Excellence (NICE) (2021)
8.2.7. Advanced Prostate Cancer Consensus Conference (APCCC) (2024)
8.2.8. Japanese Clinical Practice Guidelines for Prostate Cancer (2023)
8.2.8.1. Prostate Cancer Screening
8.2.8.2. mCSPC Treatment
9. Epidemiology and Patient Population
9.1. Key Findings
9.2. Assumptions and Rationale
9.3. Total Prevalent Cases of Prostate Cancer in the 7MM
9.4. Five-year Prevalent Cases of Prostate Cancer in the 7MM
9.5. Total Prevalent Cases of CSPC in the 7MM
9.5.1. Total Prevalent Cases of nmCSPC in the 7MM
9.5.2. Total Prevalent Cases of mCSPC in the 7MM
9.6. The United States
9.6.1. Five-year Prevalent Cases of Prostate Cancer in the US
9.6.2. Age-specific Cases of Prostate Cancer in the US
9.6.3. Total Prevalent Cases of Prostate Cancer by Clinical Stages in the US
9.6.4. Total Prevalent Cases of CSPC in the US
9.6.4.1. Total Prevalent Cases of nmCSPC in the US
9.6.4.2. Total Prevalent Cases of mCSPC in the US
9.7. EU4 and the UK
9.7.1. Five-year Prevalent Cases of Prostate Cancer in EU4 and the UK
9.7.2. Age-specific Cases of Prostate Cancer in EU4 and the UK
9.7.3. Total Prevalent Cases of Prostate Cancer by Clinical Stages in EU4 and the UK
9.7.4. Total Prevalent Cases of CSPC in EU4 and the UK
9.7.4.1. Total Prevalent Cases of nmCSPC in EU4 and the UK
9.7.4.2. Total Prevalent Cases of mCSPC in EU4 and the UK
9.8. Japan
9.8.1. Five-year Prevalent Cases of Prostate Cancer in Japan
9.8.2. Age-specific Cases of Prostate Cancer in Japan
9.8.3. Total Prevalent Cases of Prostate Cancer by Clinical Stages in Japan
9.8.4. Total Prevalent Cases of CSPC in Japan
9.8.4.1. Total Prevalent Cases of nmCSPC in Japan
9.8.4.2. Total Prevalent Cases of mCSPC in Japan
10. Patient Journey
11. Marketed Drugs
11.1. Key Competitors
11.1. ZYTIGA (abiraterone acetate): Johnson & Johnson Innovative Medicine (Janssen Pharmaceutical)
11.1.1. Product Description
11.1.2. Regulatory Milestones
11.1.3. Other Developmental Activities
11.1.4. Clinical Development activity
11.1.4.1. Clinical Trial Information in mCSPC
11.1.5. Safety and Efficacy
11.1.6. Analyst Views
11.2. XTANDI (enzalutamide): Astellas Pharma/Pfizer
11.2.1. Product Description
11.2.2. Regulatory Milestones
11.2.3. Other Developmental Activities
11.2.4. Clinical Development activity
11.2.4.1. Clinical Trial Information in nmCSPC
11.2.5. Safety and Efficacy
11.2.6. Analyst Views
11.3. NUBEQA (darolutamide): Bayer and Orion Corporation
11.3.1. Product Description
11.3.2. Regulatory Milestones
11.3.3. Other Development Activities
11.3.4. Clinical Development
11.3.4.1. Clinical Trials Information in mCSPC
11.3.4.2. Clinical Trials Information in nmCSPC
11.3.5. Safety and Efficacy
11.3.6. Analyst Views
11.4. ERLEADA (apalutamide): Johnson & Johnson Innovative Medicine (Janssen Pharmaceutical)
11.4.1. Product Description
11.4.2. Regulatory Milestones
11.4.3. Other Developmental Activities
11.4.4. Clinical Development
11.4.4.1. Clinical Trials Information in mCSPC
11.4.5. Safety and Efficacy
11.4.6. Analyst Views
11.5. ORGOVYX (relugolix): Sumitovant Biopharma/Myovant Sciences, Pfizer, and Accord Healthcare
11.5.1. Product Description
11.5.2. Regulatory Milestones
11.5.3. Other Developmental Activities
11.5.4. Safety and Efficacy
11.5.5. Analyst Views
12. Emerging Therapies
12.1. Key Competitors
12.2. TRUQAP (capivasertib/AZD5363): AstraZeneca
12.2.1. Product Description
12.2.2. Other Developmental Activities
12.2.3. Clinical Development
12.2.3.1. Clinical Trials Information in mCSPC
12.2.4. Safety and Efficacy
12.2.5. Analyst Views
12.3. TAVT-45 (abiraterone acetate): Tavanta Therapeutics
12.3.1. Product Description
12.3.2. Other Developmental Activities
12.3.3. Clinical Development
12.3.3.1. Clinical Trials Information in mCSPC
12.3.4. Safety and Efficacy
12.3.5. Analyst Views
12.4. Saruparib (AZD5305): AstraZeneca
12.4.1. Product Description
12.4.2. Other Developmental Activities
12.4.3. Clinical Development
12.4.3.1. Clinical Trials Information in mCSPC
12.4.4. Safety and Efficacy
12.4.5. Analyst Views
12.5. MVI-816 (pTVG-HP): Madison Vaccines
12.5.1. Product Description
12.5.2. Other Developmental Activity
12.5.3. Clinical Development
12.5.3.1. Clinical Trials Information in nmPSA-RPC
12.5.4. Safety and Efficacy
12.5.5. Analyst Views
12.6. AKEEGA (niraparib and abiraterone acetate): Johnson & Johnson Innovative Medicine (Janssen Pharmaceuticals)
12.6.1. Product Description
12.6.2. Other Developmental Activities
12.6.3. Clinical Development
12.6.3.1. Clinical Trial Information in mCSPC
12.6.4. Safety and Efficacy
12.6.5. Analyst Views
12.7. TALZENNA (talazoparib): Pfizer
12.7.1. Product Description
12.7.2. Other Developmental Activities
12.7.3. Clinical Development
12.7.3.1. Clinical Trial Information in mCSPC
12.7.4. Analyst Views
12.8. PLUVICTO (177Lu-PSMA-617): Novartis
12.8.1. Product Description
12.8.2. Other Development Activities
12.8.3. Clinical Development
12.8.3.1. Clinical Trials Information in mCSPC
12.8.3.2. Clinical Trials Information in Oligometastatic Prostate Cancer
12.8.4. Safety and Efficacy
12.8.5. Analyst Views
13. CSPC: 7MM Market Analysis
13.1. Key Findings
13.2. Market Outlook
13.3. Conjoint Analysis
13.4. Key Market Forecast Assumptions
13.4.1. Cost Assumptions and Rebates
13.4.2. Pricing Trends
13.4.3. Analogue Assessment
13.4.4. Launch Year and Therapy Uptake
13.5. Total Market Size of CSPC in the 7MM
13.6. Total Market Size of CSPC by Class in the 7MM
13.7. Total Market Size of CSPC by Therapies in the 7MM
13.7.1. Market Size of nmCSPC by Therapies in the 7MM
13.7.2. Market Size of mCSPC by Therapies in the 7MM
13.8. United States
13.8.1. Total Market Size of CSPC
13.8.2. Total Market Size of CSPC by Therapies in the US
13.8.2.1. Market Size of nmCSPC by Therapies in the US
13.8.2.2. Market Size of mCSPC by Therapies in the US
13.9. EU4 and the UK
13.9.1. Total Market Size of CSPC in EU4 and the UK
13.9.2. Total Market Size of CSPC by Therapies in EU4 and the UK
13.9.2.1. Market Size of nmCSPC by Therapies in EU4 and the UK
13.9.2.2. Market Size of mCSPC by Therapies in EU4 and the UK
13.1. Japan
13.10.1. Total Market Size of CSPC in Japan
13.10.2. Total Market Size of CSPC by Therapies in Japan
13.10.2.1. Market Size of nmCSPC by Therapies in Japan
13.10.2.2. Market Size of mCSPC by Therapies in Japan
14. Unmet Needs15. SWOT Analysis16. KOL Views
17. Market Access and Reimbursement
17.1. United States
17.1.1. Centre for Medicare and Medicaid Services (CMS)
17.2. EU4 and the UK
17.2.1. Germany
17.2.2. France
17.2.3. Italy
17.2.4. Spain
17.2.5. United Kingdom
17.3. Japan
17.3.1. MHLW
17.4. CSPC Market Access and Reimbursement
18. Appendix
18.1. Bibliography
18.2. Report Methodology
19. Publisher Capabilities20. Disclaimer21. About the Publisher
List of Tables
Table 1: Summary of CSPC Market and Epidemiology (2022-2036)
Table 2: Definition of Key Terminology Relating to mCSPC
Table 3: Gleason Score of Prostate Cancer
Table 4: Prostate Cancer Stage Groupings
Table 5: The National Comprehensive Cancer Network Suggests These Screening Guidelines and Recommendations for Men Older Than 45
Table 6: ADT for Patients With M0 CSPC After Maximal Pelvic Therapy
Table 7: ADT for Patients With mCSPC
Table 8: mHSPC: AUA/SUO Guideline
Table 9: Recommendations for mCSPC Management
Table 10: Guidelines for Individual Early Detection
Table 11: Guidelines for Screening and Individual Early Detection
Table 12: Guidelines for Germline Testing
Table 13: Guidelines for MRI Imaging in Biopsy Indication and Strategy
Table 14: Recommendations for Performing Prostate Biopsy
Table 15: First-line Treatment of Hormone-sensitive Metastatic Disease
Table 16: ESMO-MCBS Table for Therapies/Indications in Prostate Cancer
Table 17: Risk Stratification for People With Localized or Locally Advanced Prostate Cancer
Table 18: Prostate Cancer Screening
Table 19: mCSPC Treatment
Table 20: Prevalence of Prostate Cancer in the 7MM
Table 21: Total Prevalent Cases of Prostate Cancer in the 7MM in Thousands (2022-2036)
Table 22: Five-year Prevalent Cases of Prostate Cancer in the 7MM in Thousands (2022-2036)
Table 23: Total Prevalent Cases of CSPC in the 7MM in Thousands (2022-2036)
Table 24: Total Prevalent Cases of nmCSPC in the 7MM (2022-2036)
Table 25: Total Prevalent Cases of mCSPC in the 7MM (2022-2036)
Table 26: Five-year Prevalent Cases of Prostate Cancer in the US in Thousands (2022-2036)
Table 27: Age-specific Cases of Prostate Cancer in the US in Thousands (2022-2036)
Table 28: Total Prevalent Cases of Prostate Cancer by Clinical Stages in the US in Thousands (2022-2036)
Table 29: Total Prevalent Cases of nmCSPC in the US (2022-2036)
Table 30: Total Prevalent Cases of mCSPC in the US (2022-2036)
Table 31: Five-year Prevalent Cases of Prostate Cancer in EU4 and the UK in Thousands (2022-2036)
Table 32: Age-specific Cases of Prostate Cancer in EU4 and the UK in Thousands (2022-2036)
Table 33: Total Prevalent Cases of Prostate Cancer by Clinical Stages in EU4 and the UK in Thousands (2022-2036)
Table 34: Total Prevalent Cases of nmCSPC in EU4 and the UK (2022-2036)
Table 35: Total Prevalent Cases of mCSPC in EU4 and the UK (2022-2036)
Table 36: Five-year Prevalent Cases of Prostate Cancer in the Japan in Thousands (2022-2036)
Table 37: Age-specific Cases of Prostate Cancer in Japan in Thousands (2022-2036)
Table 38: Total Prevalent Cases of Prostate Cancer by Clinical Stages in Japan in Thousands (2022-2036)
Table 39: Total Prevalent Cases of nmCSPC in Japan (2022-2036)
Table 40: Total Prevalent Cases of mCSPC in Japan (2022-2036)
Table 41: Key Cross of Marketed Therapies in CSPC
Table 42: ZYTIGA (abiraterone acetate) in mCSPC Clinical Trial Description, 2025
Table 43: XTANDI (enzalutamide) in nmCSPC Clinical Trial Description, 2025
Table 44: NUBEQA (darolutamide) in mCSPC Clinical Trial Description, 2025
Table 45: ERLEADA (apalutamide) in mCSPC Clinical Trial Description, 2025
Table 46: Comparison of Emerging Drugs Under Development
Table 47: TRUQAP (capivasertib/AZD5363) in mCSPC Clinical Trial Description, 2025
Table 48: TAVT-45 (abiraterone acetate) in mCSPC Clinical Trial Description, 2025
Table 49: Saruparib (AZD5305) in mCSPC Clinical Trial Description, 2025
Table 50: MVI-816 (pTVG-HP) in nmPSA-RPC Clinical Trial Description, 2025
Table 51: AKEEGA (niraparib and abiraterone acetate) in mCSPC Clinical Trial Description, 2025
Table 52: TALZENNA (talazoparib) in mCSPC Clinical Trial Description, 2025
Table 53: PLUVICTO ( 177Lu-PSMA-617) in mCSPC Clinical Trial Description, 2025
Table 54: PLUVICTO ( 177Lu-PSMA-617) in Oligometastatic Prostate Cancer Clinical Trial Description, 2025
Table 55: Key Market Forecast Assumption of nmCSPC Market in the US
Table 56: Key Market Forecast Assumption of nmCSPC in EU4 and the UK
Table 57: Key Market Forecast Assumption of nmCSPC Market in Japan
Table 58: Key Market Forecast Assumption of mCSPC in the US
Table 59: Key Market Forecast Assumption of mCSPC in EU4 and the UK
Table 60: Key Market Forecast Assumption of mCSPC in Japan
Table 61: Total Market Size of CSPC in the 7MM, USD million (2022-2036)
Table 62: Total Market Size of Prostate Cancer by Class in the 7MM, USD million (2022-2036)
Table 63: Market Size of nmCSPC by Therapies in the 7MM, USD million (2022-2036)
Table 64: Market Size of nmCSPC by Therapies in the 7MM, USD million (2022-2036)
Table 65: Total Market Size of CSPC in the US, USD million (2022-2036)
Table 66: Market Size of nmCSPC by Therapies in the US, USD million (2022-2036)
Table 67: Market Size of nmCSPC by Therapies in the US, USD million (2022-2036)
Table 68: Total Market Size of CSPC in EU4 and the UK, USD million (2022-2036)
Table 69: Market Size of nmCSPC by Therapies in EU4 and the UK, USD million (2022-2036)
Table 70: Market Size of nmCSPC by Therapies in the 7MM, USD million (2022-2036)
Table 71: Total Market Size of CSPC in Japan, USD million (2022-2036)
Table 72: Market Size of nmCSPC by Therapies in Japan, USD million (2022-2036)
Table 73: Market Size of nmCSPC by Therapies in Japan, USD million (2022-2036)
Table 74: IQWiG Assessment for Prostate Cancer Therapies
Table 75: HAS Decisions for Prostate Cancer Therapies
Table 76: AIFA Assessment for Prostate Cancer Therapies
Table 77: AEMPS Assessment for Prostate Cancer Therapies
Table 78: NICE Decisions for Prostate Cancer Therapies
List of Figures
Figure 1: Clinical Course Of Prostate Cancer
Figure 2: Management of nmCSPC With Biochemical Recurrence
Figure 3: Flow Diagram For Deciding on Prostate Biopsy
Figure 4: NCCN Guideline for Early Detection Evaluation of Prostate Cancer
Figure 5: Mechanism of Action of ADT
Figure 6: Treatment Intensification Based on Risk
Figure 7: Radical Prostatectomy PSA Persistence/Recurrence
Figure 8: Radiation Therapy Recurrence
Figure 9: Treatment And Monitoring For Progressive M0 CSPC After Maximal Pelvic Therapy
Figure 10: Systemic Therapy for M1 CSPC
Figure 11: Treatment of Metastasized (M1*) - Disease, mHSPC
Figure 12: Algorithm for mCSPC Treatment
Figure 13: Global Heat Map of Prostate Cancer
Figure 14: Total Prevalent Cases of Prostate Cancer in the 7MM (2022-2036)
Figure 15: Five-year Prevalent Cases of Prostate Cancer in the 7MM (2022-2036)
Figure 16: Total Prevalent Cases of CSPC in the 7MM (2022-2036)
Figure 17: Total Prevalent Cases of nmCSPC in the 7MM (2022-2036)
Figure 18: Total Prevalent Cases of mCSPC in the 7MM (2022-2036)
Figure 19: Five-year Prevalent Cases of Prostate Cancer in the US (2022-2036)
Figure 20: Age-specific Cases of Prostate Cancer in the US (2022-2036)
Figure 21: Total Prevalent Cases of Prostate Cancer by Clinical Stages in the US (2022-2036)
Figure 22: Total Prevalent Cases of nmCSPC in the US (2022-2036)
Figure 23: Total Prevalent Cases of mCSPC in the US (2022-2036)
Figure 24: Five-year Prevalent Cases of Prostate Cancer in EU4 and the UK (2022-2036)
Figure 25: Age-specific Cases of Prostate Cancer in EU4 and the UK (2022-2036)
Figure 26: Total Prevalent Cases of Prostate Cancer by Clinical Stages in EU4 and the UK (2022-2036)
Figure 27: Total Prevalent Cases of nmCSPC in EU4 and the UK (2022-2036)
Figure 28: Total Prevalent Cases of mCSPC in EU4 and the UK (2022-2036)
Figure 29: Five-year Prevalent Cases of Prostate Cancer in Japan (2022-2036)
Figure 30: Age-specific Cases of Prostate Cancer in Japan (2022-2036)
Figure 31: Total Prevalent Cases of Prostate Cancer by Clinical Stages in Japan (2022-2036)
Figure 32: Total Prevalent Cases of nmCSPC in Japan (2022-2036)
Figure 33: Total Prevalent Cases of mCSPC in Japan (2022-2036)
Figure 34: Total Market Size of CSPC in the 7MM in USD million (2022-2036)
Figure 35: Total Market Size of CSPC by class in the 7MM, USD million (2022-2036)
Figure 36: Market Size of nmCSPC by Therapies in the 7MM in USD million (2022-2036)
Figure 37: Market Size of mCSPC by Therapies in the 7MM in USD million (2022-2036)
Figure 38: Total Market Size of CSPC in the US, USD million (2022-2036)
Figure 39: Market Size of nmCSPC by Therapies in the US in USD million (2022-2036)
Figure 40: Market Size of mCSPC by Therapies in the US in USD million (2022-2036)
Figure 41: Total Market Size of CSPC in EU4 and the UK, USD million (2022-2036)
Figure 42: Market Size of nmCSPC by Therapies in EU4 and the UK in USD million (2022-2036)
Figure 43: Market Size of mCSPC by Therapies in EU4 and the UK in USD million (2022-2036)
Figure 44: Total Market Size of CSPC in Japan, USD million (2022-2036)
Figure 45: Market Size of nmCSPC by Therapies in Japan in USD million (2022-2036)
Figure 46: Market Size of mCSPC by Therapies in Japan in USD million (2022-2036)
Figure 47: Health Technology Assessment
Figure 48: Reimbursement Process in Germany
Figure 49: Reimbursement Process in France
Figure 50: Reimbursement Process in Italy
Figure 51: Reimbursement Process in Spain
Figure 52: Reimbursement Process in the United Kingdom
Figure 53: Reimbursement Process in Japan

Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • Janssen Research and Development
  • AstraZeneca
  • Merck
  • Pfizer
  • Astellas Pharma
  • Bayer
  • Novartis