Microglial Aging: Basic, Translational, and Clinical Advances explores groundbreaking research on microglial function in the context of aging. This comprehensive resource delves into the physiological roles of microglia, the effects of aging on their structure and activity, and their significance in age-related neurodegenerative diseases. With insights from basic, translational, and clinical studies, it provides a thorough understanding of microglial health and its impact on aging. The book discusses how lifestyle choices can enhance microglial functions and prevent neurodegenerative diseases. It covers both pharmacological and non-pharmacological approaches, such as the ketogenic diet, cannabinoids, psychedelics, and non-invasive vagal nerve stimulation.
This text is invaluable for researchers and clinicians focused on improving the quality of life for an aging population.
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Table of Contents
SECTION 1: Introduction to microglial aging and its involvement in neurodegenerative diseases1 Introduction to microglial aging and its involvement in neurodegenerative diseases
2 Involvement of microglial aging in neurodegenerative diseases: a focus on Parkinson’s disease
3 Involvement of microglial aging in neurodegenerative diseases: a focus on multiple sclerosis
4 Involvement of microglial aging in neurodegenerative diseases: a focus on amyotrophic lateral sclerosis
SECTION 2: Outcomes of the lifestyle on microglial aging and neurodegenerative diseases along the aging trajectory
5 Outcomes of the lifestyle on microglial aging and neurodegenerative diseases along the aging trajectory: diet and the gut-brain axis
6 Sleep disturbance as a modulator of microglial morphology and function: implications for neurodegenerative disease
7 The effects of bacterial and viral infections on microglia
8 Physical activity and microglial metabolism in neurodegenerative diseases
SECTION 3: Emerging treatment strategies to rejuvenate microglia in aging and neurodegenerative diseases
9 Microglial senescence and senolytic drugs
10 Cannabinoids as modulators for Alzheimer’s disease: a role for microglia?
11 Psychedelics and microglia in aging: unraveling the secret dialogue behind healthy aging, mental health, and neuroinflammation
12 Effects of plasmalogens on microglial function and neuroinflammation: mechanisms and implications in aging and neurodegenerative diseases
Appendix: Epilogue
Index
Authors
Marie-Eve Tremblay Full Professor, School of Medical Sciences, Faculty of Health, University of Victoria, BC, Canada.Dr. Marie-�ve Tremblay is a Full Professor at the School of Medical Sciences, University of Victoria, British Columbia, Canada. She was awarded a Tier II Canada Research Chair in Neurobiology of Aging and Cognition until 2025. Dr. Tremblay is an internationally recognized leader in microglial research. Her career goal is to become a world leader in the development of innovative therapies normalizing microglial functions upon exposure to various environmental risk factors for disease throughout life. She has been invited to present her work over 143 times, at seminars, lectures at symposia, specialized courses, and other meetings. She has 182 publications cited 11,854 times, corresponding to an h-index of 50 and i10-index of 116 (Google Scholar). She was also named a Clarivate Highly Cited Researcher, being among the top 1% across fields in 2021 and 2022 and is ranked 4th world microglial expert by ExpertScape.
