Protein Dynamics: Experimental and Computational Approaches investigates protein biology from a biophysical standpoint. The book covers a wide range of topics, including functional protein dynamics, intrinsically disordered proteins, protein folding, misfolding and aggregation, and membrane protein-protein communication. Protein allosteric conformational changes caused by drug binding and disease-associated mutations are also featured, alongside protein dynamics in the context of computer-based drug design. Biophysical techniques for investigating protein structure-dynamics-function relationships across these topics are explored, considering the latest experimental and computational approaches in the field. This book is an ideal reference for researchers in working in biophysics, biochemistry, and related areas.
Table of Contents
1. Introduction2. Functional protein dynamics
3. Protein-protein communication in membrane protein organization and cell signaling
4. Intrinsically disordered proteins
5. Role of entropy in protein folding
6. Functional water molecules and role of ions in protein function
7. Computing transition states in enzyme reactions
8. G Protein Receptor Signaling
9. Protonation-coupled protein dynamics studied with graph algorithms
10. Membrane transporters
11. Lipids and lipid-protein dynamics in membrane protein function
12. Protein misfolding and aggregation
13. Proteins of extremophiles
14. Protein allosteric conformational changes caused by drug binding and disease-associated mutations
15. Computer-based drug design
16. Amyloid precursor protein in Alzheimer's disease
Authors
Ana-Nicoleta Bondar Professor, Faculty of Physics, University of Bucharest, Bucharest, RomaniaVisiting professor, Forschungszentrum J�lich, Institute for Computational Biomedicine, Germany. Ana-Nicoleta Bondar is a full professor of physics at the Faculty of Physics, University of Bucharest, Romania, and currently a visiting professor at the Forschungszentrum J�lich, Institute for Computational Biomedicine, Germany. Prior to this, she led the theoretical molecular biophysics group at the Freie Universit�t Berlin, Department of Physics. Dr. Bondar's research is focused on methodological developments and applications for membrane proteins. Durba Sengupta Principle Scientist and Assistant Professor, Physical Chemistry Division, CSIR-National Chemical Laboratory, Pune, India
Scientist Fellow (Ramalingaswami Fellow), Physical Chemistry Division, CSIR-National Chemical Laboratory, Pune, India. Durba Sengupta is Principle Scientist and Assistant Professor at the Physical Chemistry Division
CSIR-National Chemical Laboratory, Pune, India. The main objective of Dr Sengupta's research group is to understand self organisation and self-assembly in complex bio-systems, using the tools of physical chemistry. The current focus of her research is membrane biology and understanding the structure, dynamics and functions of proteins, lipids, sugars and sterols within the membrane.
