Each chapter explores specific body systems, including renal, urological, cardiovascular, and respiratory, uncovering the diagnostic potential of urine biomarkers in various conditions like cancer, cardiovascular diseases, and neurological disorders. Highlighted are the latest advances in technology, challenges, and future directions, keeping readers abreast of the rapidly evolving landscape of urine biomarker research. Real-world case studies illustrate practical applications, enhancing comprehension and facilitating knowledge transfer to clinical practice.
Table of Contents
Section I. Introduction1. Background and Significance and Historical Perspective of Urine Biomarkers in Medicine
2. Rationale for Exploring Urine Biomarkers
Section II. Fundamentals of Urine Biomarkers
3. Definition and Types of Biomarkers
4. Characteristics of Ideal Urine Biomarkers
Section III. Molecular Signatures in Urine
5. Cellular Components in Urine
6. Genetic and Epigenetic Markers
7. Proteomic and Metabolomic Signatures
8. MicroRNA and Non-Coding RNA Profiles
Section IV. Urine Biomarkers Across Body Systems
9. Renal System
10. Urological System
11. Cardiovascular System
12. Endocrine System
13. Musculoskeletal System
14. Immune System
15. Respiratory System
16. Blood system
17. Digestive system
18. J. Nervous system
Section V. Techniques for Urine Biomarker Detection
19. Laboratory Techniques
20. Point-of-Care Testing
Section VI. Clinical Implications and Applications
21. Diagnosis and Prognosis
22. Monitoring Disease Progression
23. Treatment Response Assessment
24. Personalized Medicine Approaches
Section VII. Challenges and Limitations
25. Standardization Issues
26. Variability in Urine Composition
27. Ethical Considerations
28. Cost-effectiveness
Section VIII. Future Directions and Emerging Trends
29. Advances in Technology
30. Integration with Other Diagnostic Modalities
31. Potential Therapeutic Targets
Section IX. Case Studies
32. Real-world Applications of Urine Biomarkers
33. Success Stories and Lessons Learned
Section X. Conclusion
34. Implications for Future Research and Clinical Practice
35. Summary of Key Findings
Authors
Cheng Xue Shanghai Changzheng Hospital, Second Military Medical University (Naval Medical University), China.Cheng Xue, currently serving as a Medical Doctor in the Department of Nephrology at Shanghai Changzheng Hospital affiliated with Naval Medical University, holds the position of Deputy Chief Physician. He contributes significantly to the medical community through various editorial roles, including Guest Associate Editor at Frontiers of Nephrology and serving on the editorial boards of Urine, Journal of Clinical Nephrology, and JTIM.
With an impressive publication record, Cheng Xue has authored 55 papers indexed in SCI journals and 23 papers in prominent Chinese journals, including NEJM, JASN, KI, AJKD, NDT, among others. His research spans across leading medical publications, demonstrating his expertise and contribution to the field.
Furthermore, Cheng Xue has led significant research projects, including hosting a National Natural Science Foundation project and a China Postdoctoral Science Foundation project. His innovative work has resulted in the acquisition of 11 national patents, reflecting his dedication to advancing medical science and improving patient care.
Jing Xu Second Military Medical University (Naval Medical University), China.Dr. Jing Xu, M.D., Ph.D., is an esteemed Associate Professor in the Department of Nephrology at Shanghai Changzheng Hospital. With extensive expertise, she specializes in diagnosing and treating both acute and chronic kidney dysfunction stemming from conditions such as chronic glomerulonephritis, diabetes, and hypertension. Dr. Xu excels in managing critical nephropathy using various blood purification methods, including intermittent hemodialysis, bedside continuous renal replacement therapy, and peritoneal dialysis. Her proficiency extends to establishing access for these therapies.
Dr. Xu's dedication to advancing knowledge in nephrology is evident through her research focus on decoding the mechanisms of chronic kidney fibrosis and persistent inflammation following acute kidney injury, particularly centering on the Hippo pathway and its components. Her contributions have been recognized with several grants from the National Science Foundation and the local medical ministry.
Furthermore, Dr. Xu has authored numerous research articles in prestigious journals such as CJASN, NDT, and CKJ, often as the (co-)first or (co-)correspondence author. Her commitment to academic excellence is further reflected in her role as a young committee member of several local nephrology academic communities.
Bo Yang Naval Medical Center of PLA, Second Military Medical University, China.Bo Yang, MD, specializes in Internal Medicine III (Nephrology) at the Naval Medical Center of the People's Liberation Army (PLA), affiliated with the Second Military Medical University in Shanghai. Dr. Yang's expertise in nephrology contributes significantly to the medical care and research efforts at this esteemed institution.
Lyu Jiayi Associate Chief Physician, Department of Nephrology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, China.Lyu Jiayi, MD is Associate Chief Physician within the Department of Nephrology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, China. Dr. Jiayi received her PhD in Nephrology from Shanghai Changzheng Hospital and completed the Joint Ph.D. Training Program with the Mayo Clinic. Dr. Jiayi's research is focused on pathogenesis, diagnosis, and treatment of autosomal dominant polycystic kidney disease (ADPKD) as well as clinical management of acute and chronic kidney diseases.
