Building Blocks of Neuroimmunometabolism: From Molecular Pathways to Therapeutic Strategies offers an authoritative exploration of the intricate relationship between the immune system and neurodegenerative diseases. This essential resource addresses the critical gap in understanding how immune responses and metabolic processes jointly influence the onset and progression of conditions such as Alzheimer’s, Parkinson’s, and multiple sclerosis. The book provides an examination of key molecular pathways and cellular interactions, emphasizing the role of immunometabolism in disease mechanisms. Beginning with an introduction to the concept of immunometabolism, it explores the connections between the immune and nervous systems, setting the stage for understanding neurodegenerative diseases.
In addition, the book discusses pivotal topics such as the role of microglia and macrophages in neuroinflammation, the metabolic regulation of T cells, and the impact of oxidative stress and mitochondrial dysfunction. The gut-brain axis is examined for its influence on brain health, alongside innovative therapeutic strategies targeting immunometabolic pathways and lifestyle interventions.
In addition, the book discusses pivotal topics such as the role of microglia and macrophages in neuroinflammation, the metabolic regulation of T cells, and the impact of oxidative stress and mitochondrial dysfunction. The gut-brain axis is examined for its influence on brain health, alongside innovative therapeutic strategies targeting immunometabolic pathways and lifestyle interventions.
Table of Contents
1. Introduction to Neuroimmunometabolism: Connecting Immune and Nervous Systems2. Molecular Pathways Linking Immunity and Neurodegeneration
3. Role of Macrophages in Immunometabolism and Neurodegeneration
4. Role of Microglia in Neurodegenerative Disorders
5. Metabolic Regulation of T Cells in Neuroinflammation
6. Oxidative Stress and Mitochondrial Dysfunction in Immune-Mediated Neurodegeneration
7. Role of Cytokines and Chemokines in Neurodegenerative Disease Progression
8. The Gut-Brain Axis: Immunometabolic Crosstalk in Neurodegenerative Diseases
9. Inflammatory Pathways in Alzheimer’s Disease: The Immunometabolic Perspective
10. Parkinson’s Disease and Immune-Metabolic Dysregulation
11. Multiple Sclerosis: Immune and Metabolic Interactions in Neuroinflammation
12. Autoimmune Diseases and Their Role in Neurodegeneration
13. Immunometabolism in Aging and Neurodegenerative Disorders
14. Therapeutic Potential of Targeting Immuno-metabolic Pathways and Lifestyle Interventions on Immunometabolism and Neurodegeneration
15. Emerging Technologies for Studying Immunometabolism in Neurodegenerative Disorders
16. Future Directions: Bridging Immunometabolism and Precision Medicine in Neurology
Authors
Sachchida Nand Rai Assistant Professor.Dr. Sachchida Nand Rai is an Assistant Professor at University Centre for Research & Development (UCRD), Chandigarh University, Punjab, India. He obtained his MSc in Biochemistry from Purvanchal University, India, and his PhD in Biochemistry from Banaras Hindu University, India. Dr. Rai researches the anti-oxidative and anti-neuroinflammatory properties of phytochemicals for the treatment of neurodegenerative diseases. He is a lifetime member of the Indian Academy of Neuroscience.
Shradha Bisht Professor of Pharmacology, Banaras Hindu University. Dr. Shradha Bisht, a Professor of Pharmacology, is a distinguished researcher with a Ph.D. in Pharmacy from RUHS, Jaipur, and a Master of Pharmacy in Pharmacology from M.S. University of Baroda. Her research primarily focuses on neurodegenerative disorders, immunometabolism, and innovative drug delivery systems. Dr. Bisht has made significant contributions to the field on the therapeutics for diabetes and hepatic dysfunction and on nanotechnology-driven strategies for managing neurodegenerative disorders. She is an active member of the Association of Pharmaceutical Teachers of India and the Indian Pharmacological Society. Dr. Bisht's excellence in research was recognized with the Young Women Scientist Achievement Award in 2024 by USERC. Her scholarly work also includes authoring book chapters on neurochemical signaling in Alzheimer's disease and exploring non-pharmacological interventions. Dr. Bisht continues to advance the field with her innovative approaches and dedication to pharmacological research. Swati Prakash Assistant Professor of Pharmacology, Amity University. Dr. Swati Prakash, an Assistant Professor of Pharmacology, is a dedicated researcher with a Ph.D. in Pharmacology from the Indian Institute of Technology (BHU), Varanasi, and a Master's degree from Guru Ghasidas University, Bilaspur. Her research spans neurodegenerative disorders, immunometabolism, metabolic complications, and advanced drug delivery systems. Dr. Prakash has contributed significantly to the understanding of chronic inflammation and cancer, exploring key pathways and targeted therapies. Her published work on the regulation of adipose tissue inflammation and hepatic Adiponectin/AMPK levels demonstrates her expertise in addressing metabolic syndrome and fatty liver disease. Through her innovative research, Dr. Prakash is advancing the field of pharmacology, focusing on therapeutic approaches that improve health outcomes. Her academic credentials and impactful publications underscore her commitment to scientific excellence and her role as a leading researcher in pharmacological sciences.
