Additionally, it explores traditional management approaches like antioxidant supplements, lifestyle changes, and low vision aids, alongside novel treatments such as complement inhibitors, cell-based therapies, and gene therapy, to inform clinicians about the latest advancements and research in patient care. With the recent FDA approval for GA treatment, there has been significant interest in the retina community. This rapidly growing field necessitates a new book on geographic atrophy in age-related macular degeneration to address gaps in existing literature and provide up-to-date, comprehensive information.
Table of Contents
1. Definitions2. Histopathology and mechanisms
3. Epidemiology and risk factors including genetics
4. Non-dye-based imaging, Fundus photo, IR, FAF
5. OCT
6. OCTA
7. Dye-based imaging (FA, ICG)
8. Visual Function test (electrophysiology, dark adaptation, etc)
9. Differential diagnosis and masquerades
10. GA progression
11. GA association with CNV
12. Role of AI in diagnosis and follow-up
13. GA management (prevention, old treatments, new treatments with side effects, Visual cycle modulators, mTOR inhibitors, complement inhibitors, MMP inhibitors, LDL lowering drugs, Anti-amyloid beta, Antioxidants and neuroprotectants; Choroidal perfusion enhancers
14. GA management (Surgical approaches)
15. Failed approaches in GA
16. Learnings from GA clinical trials
17. Burden of disease, visual rehabilitation, Psychosocial Impact
18. Personalized medicine in GA: The future is here
Authors
Jay Chhablani UPMC Vision Institute, USA.Jay Chhablani MD is Professor of Ophthalmology and vitreo-retina surgeon at the University of Pittsburgh Eye Center, USA. He established the "Choroid Analysis and Research (CAR) Lab,� which focuses on computational as well as biological research in the field of choroid. He has published more than 650 articles in peer-reviewed journals with a focus in the field of choroid. He is the editor of books "Choroidal Disorders,� "Central Serous Chorioretinopathy� and "Choroidal Neovascularization.� He is on the editorial board of several journals, including the American Journal of Ophthalmology. He has won several national and international awards and delivered named lectures.
Caroline R. Baumal Apellis Pharmaceuticals, USA.As a board-certified ophthalmologist, Caroline R. Baumal MD, FASRS has authored over 170 publications and has been recognized with numerous prestigious awards, including the Senior Achievement Award from the American Academy of Ophthalmology, the Crystal Apple Award from the American Society of Retina Specialists, and the Lifetime Achievement Award from the Vit-Buckle Society. She also has been involved with research and clinical trials investigating novel therapies for retinal diseases. Caroline studied biochemistry at McGill University and received an MD from the University of Toronto, where she also completed her ophthalmology residency followed by two fellowships: Retinal Surgery at Wills Eye Hospital and Medical Retinal and Lasers at New England Eye Center.
