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Precision Oncology in Liver Cancer. Genomics, Infection, and the Exposome in African and Global Contexts

  • Book

  • November 2026
  • Region: Africa, Global
  • Elsevier Science and Technology
  • ID: 6251477
Precision Oncology in Liver Cancer: Genomics, Infection, and the Exposome in African and Global Contexts explores liver cancer through the lens of precision medicine, integrating molecular profiling, environmental exposures, and targeted therapies. The book presents a multidisciplinary approach, covering infectious drivers like HBV/HCV, environmental carcinogens such as aflatoxins, and emerging tools including genomics, AI, and liquid biopsies. It emphasizes African-specific challenges and innovations, with case studies and comparative global insights. This volume equips researchers, clinicians, and policymakers with evidence-based strategies to address liver cancer disparities, offering a forward-looking framework for equitable cancer care and research in Africa and globally.

Table of Contents

1. The Global Burden of Liver Cancer
2. Liver Cancer in Africa
3. Health Systems and Precision Readiness
4. Hepatitis B and C
5. HIV, Liver Disease, and Cancer
6. Parasitic and Bacterial Infections
7. Aflatoxins in African Diets
8. Urbanization, Pollution, and Industrial Waste
9. Alcohol, Herbal Remedies, and Cultural Practices
10. The Genomic Landscape of Liver Cancer
11. African Genomes and the Precision Gap
12. The Liver-Gut Microbiome Axis
13. Liquid Biopsy and Predictive Biomarkers
14. Artificial Intelligence in Liver Cancer
15. Patient-Centric Technologies
16. Integrating Multi-Omics and Systems Thinking
17. Decolonizing Liver Cancer Research
18. Vision for the Future

Authors

Zodwa Dlamini University of Pretoria, South Africa. Zodwa Dlamini is a Professor of Molecular Oncology and the founding Director and the Executive Head of the Pan African Cancer Research Institute (PACRI) in South Africa. She is the Director of South African Medical Research Council (SAMRC) Precision Oncology Research Unit (PORU). She is the DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP). She is a member of the American Association for Cancer Research (AACR) Advisory Group on Sub-Saharan Africa. She is a member of the AACR Pathology Resources in Africa Advisory Group. Professor Dlamini is a member of the African Organisation for Research and Training in Cancer (AORTIC) Research Committee Scientific Advisory Board. She is an elected member of the Academy of Science of South Africa. Professor Dlamini is an overseas Fellow of the Royal Society of Medicine (London). She is the Associate Editor for Frontiers in Oncology: Cancer Genetics Section