Necroptosis: A Programmed Cell Death Machinery in Human Health provides a comprehensive review of the evolving concepts of programmed cell death (PCD) machinery. The book traces the evolutionary origin of necroptosis, necroptotic proteins, and how the proteins contribute to necroptosis and other cell death pathways. It clarifies necroptosis as more than merely an alternate to extrinsic apoptosis but explores it as an inflammatory form of cell death interconnected with multiple death signaling that ultimately dictates physiological outcome. Coverage summarizes the role of the death pathway and proteins in mammalian health and disease as well as key diseases where they play recognized contributing roles. The involvement of necroptosis in pulmonary diseases including activation during SARS-CoV2 infection is covered along with other gastroenteric diseases, cancer, and aging. Beyond conveying clinical knowledge, these topics will be of strong research interest to the biomedical bench scientist.
Table of Contents
1. Introduction
2. Evolution of programmed cell death pathways with focus on necroptosis
3. Necroptosis, necroptotic proteins and regulation of necroptotic signaling, as well as contribution in important physiological signaling including development
4. Cell death, necroptosis, and acute inflammatory Disease
5. Cell death, necroptosis and chronic inflammatory diseases:
6. Necroptosis and Tumor
7. Necroptosis and infections
8. DNA viruses and cell death
9. RNA viruses and cell death
10. Bacteria and cell death
11. Cell death and necroptosis during emerging infections
12. Cell death proteins in death-independent inflammation
13. Future Directions
