Table of Contents
1. Introduction to Ubiquitination: Mechanisms, enzymes (E1, E2, E3), and biological significance2. Structural level of Ubiquitination through the eyes of Cryo-EM, X-ray crystallography, and NMR
3. Structural biology of Ubiquitin ligases
4. Computational Biophysics in Ubiquitination Studies
5. Dysregulation of Ubiquitination in Cancer: Molecular mechanisms and oncogenic pathways
6. Deubiquitinases (DUBs) as Cancer Regulators: Structural and Computational Insights for targeted therapy
7. Dysregulation of Ubiquitination in Neurodegeneration: Molecular mechanisms and neurodegenerative pathways
8. Deubiquitinases (DUBs) in Amyotrophic Lateral Sclerosis (ALS): Mechanisms and therapeutic interventions
9. AI and Machine Learning in Ubiquitination and Drug Discovery
10. PROTACs and Targeted Protein Degradation Strategies in Ubiquitination-linked Disease Therapy
11. Challenges and Future Perspectives in Ubiquitination Research
12. Translational Research and Clinical Trials in Ubiquitination-Targeted Therapy

