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Molecular Mechanisms of Cancer Resistance. Emerging Technologies and Therapeutic Strategies. Novel approaches to overcome cancer resistance to conventional therapies

  • Book

  • November 2026
  • Elsevier Science and Technology
  • ID: 6251602
Molecular Mechanisms of Cancer Resistance: Emerging Technologies and Therapeutic Strategies explores innovative tools and strategies designed to address the critical issue of drug resistance in cancer treatment. This comprehensive volume is tailored for researchers, clinicians, and students, offering insights into the latest advancements and methodologies in the field. The book covers essential topics such as molecular mechanisms of drug resistance, the tumor microenvironment, and emerging technologies like single-cell analysis and computational modeling. Each chapter features contributions from leading experts, providing a multi-dimensional perspective on both foundational concepts and cutting-edge research. By engaging with this book, the academic audience gains access to groundbreaking research and therapeutic strategies that enhance understanding and practice. The knowledge acquired will inspire collaboration and innovation, ultimately contributing to more effective and personalized cancer treatment approaches.

Table of Contents

1. General Introduction to Drug Resistance in Cancer
2. Genomic and Epigenomic Factors in Drug Resistance
3. Role of the Tumor Microenvironment
4. Technological Advances in Single-Cell Analysis
5. Advances in Organoids and 3D Models
6. Drug Development and Resistance Testing
7. Artificial Intelligence and Machine Learning in Drug Resistance Research
8. Computational Modelling in Cancer Resistance
9. Emerging Therapies for Overcoming Resistance
10. Resistance Mechanisms in Rare and Pediatric Cancers
11. Case Studies and Clinical Applications
12. Overall Conclusions and Future Perspectives

Authors

Ahmet Acar Middle East Technical University, Ankara, Turkey. Dr. Ahmet Acar completed his undergraduate studies at Middle East Technical University (METU) in Ankara, Turkey, where he now serves as an Associate Professor in the Department of Biology. He earned his PhD at Cancer Research UK Manchester Institute and gained extensive postdoctoral experience in cellular and cancer biology at the University of Manchester and the Institute of Cancer Research in London. After 12 years of research in the UK, Dr. Acar returned to Turkey in 2020, establishing his research group at METU with support from T�BITAK's International Fellowship for Outstanding Researchers Program. Dr. Acar's research focuses on cellular biology and cancer, leveraging his rich academic and professional background