It equips formulation scientists, R&D professionals, and students with the knowledge to accelerate research, improve efficiency, and translate laboratory innovations into market-ready solutions.
Table of Contents
Section I: Instrumentation & Equipment1. Introduction to Hot-Melt Extrusion Equipment
Section II: Material Selection & Material Processing Prediction/Preformulation
2. Materials, Material Selection & Material Processing
Section III: Drug Delivery Systems & Solubilization Techniques
3. Granulation
4. Pellets
5. Taste-Masking
6. Topical Dosage Forms
7. Films Oral, Topical & Transdermal
8. Sterile Dosage Forms in Continuous Manufacturing by Hot-Melt Extrusion Technology
9. Co-Crystallization
10. Solubility & Bioavailability Enhancement
11. Abuse Deterrent/Tamper-Resistant Formulation
12. HME vs. Spray Drying
Section IV: Advances in HME
13. Advanced Polymers & Excipients
14. Vertical HME (Innovation in Instrumentation/Equipment)
15. 3D Printing/Patient-Centric Formulation Customization
16. Recent Innovations in HME
Section V: Patentability, Quality Control, Quality Assurance, QbD-Predictive Models & Regulatory Compliance
17. Patentability of HME Products
18. Quality-Assured Development & Scale-Up
19. Regulatory Compliance FDA and Other Regulatory Bodies
Authors
Purnima D. Amin Senior Professor of Pharmacy, Institute of Chemical Technology (formerly UDCT), Mumbai, India.Prof. Purnima D. Amin is Senior Professor of Pharmacy at the Institute of Chemical Technology (formerly UDCT), Mumbai, with over three decades of academic and research leadership in pharmaceutics. She earned her B.Pharm (1982), M.Pharm (1984), and Ph.D. (Tech) in Pharmaceutics (1988) from UDCT, Mumbai, where her doctoral work focused on polymeric drug delivery systems.
A pioneer in the field of pharmaceutical technology, Prof. Amin's research centers on the development of innovative drug delivery systems through Hot Melt Extrusion (HME). Her group has produced more than 60 publications in HME and holds multiple patents in the field. Her contributions span solubility enhancement of poorly soluble drugs, fixed-dose combinations for tuberculosis and malaria, orally disintegrating films, topical formulations, probiotic inserts, nanostructured lipid carriers, and sustained-release implants for both human and veterinary applications.
In addition to her extensive academic work, Prof. Amin has collaborated with leading pharmaceutical companies, including Merck, BASF, Evonik, and Hindustan Unilever, ensuring translation of her laboratory innovations into industrially scalable dosage forms. She has supervised over 30 Ph.D. and 75 Master's students, and her expertise is widely recognized through awards at international forums, editorial roles (including Remington: The Science and Practice of Pharmacy), and service as a reviewer for leading journals.
