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Optimizing Sedation & Analgesia in the ICU, An Issue of Critical Care Clinics. The Clinics: Internal Medicine Volume 41-4

  • Book

  • November 2025
  • Elsevier Health Science
  • ID: 6252009
In this issue of Critical Care Clinics, guest editors Drs. Yahya Shehabi, Joanna L. Stollings, and Timothy D. Gerard bring their considerable expertise to the topic of Optimizing Sedation and Analgesia in the ICU. Top experts cover key issues such as the role of antipsychotic agents for adjunct sedation; analgesia first for every patient: current concepts in critical illness; monitoring sedation depth in critical illness; inhalational agents as ICU sedatives; and much more.- Contains 14 relevant, practice-oriented topics including optimal sedation in the elderly critically ill; sedation in non-invasive ventilation; optimal sedation in ventilated patients with septic shock; optimal sedation in the patients with acute brain injury including post cardiac arrest; future directions in sedation and analgesia; and more- Provides in-depth clinical reviews on optimizing sedation and analgesia in the ICU, offering actionable insights for clinical practice- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews

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Table of Contents

Pharmacology of Commonly Used Sedative Agents
Pharmacology of Alpha-2 Agonists Applied to Sedation, Sleep, and Analgesia
Role of Antipsychotic Agents for Adjunct Sedation
Analgesia First in Critically Ill Adults: Current Practices and Future Directions
Monitoring Sedation Depth in Critical Illness, State-of-the-Art Practice
Inhalational Agents as Intensive Care Unit Sedatives
Optimal Sedation in Older Critically Ill Adults
Sedation and Noninvasive Positive Pressure Ventilation-Where are We now? A Narrative Review
Optimal Sedation in Ventilated Patients with Sepsis and Septic Shock
Optimal Sedation During Severe Acute Respiratory Distress Syndrome
Optimal Sedation and Analgesia in Patients with Polytrauma, Excluding Brain Injury
Optimal Sedation and Analgesia for Critical Care Patients with Acute Brain Injury Including Post-Cardiac Arrest
Optimal Sedation in Ventilated Patients with Cardiovascular Surgery and/or Shock
Future Directions in Sedation and Analgesia

Authors

Yahya Shehabi Monash University, Monash Health School of Clinical Sciences. University of New South Wales, Prince of Wales School of Clinical Medicine, Melbourne, Australia. Joanna L. Stollings Department of Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, TN, USA Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center, Nashville, TN, USA. Timothy D Girard Center for Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) in the Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.