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Hemophagocytic Syndromes, An Issue of Hematology/Oncology Clinics of North America. The Clinics: Internal Medicine Volume 39-3

  • Book

  • July 2025
  • Region: North America
  • Elsevier Health Science
  • ID: 6252319
In this issue of Hematology/Oncology Clinics, guest editors Drs. Nancy Berliner and Barbara A. Degar bring their considerable expertise to the topic of Hemophagocytic Syndromes. Top experts provide in-depth perspectives on these uncommon but potentially life-threatening disorders, including pathology of histiocytic disorders, genomic alterations in LCH, immunopathology of HLH, clinical characteristics and treatment of familial HLH, and much more.- Contains 11 relevant, practice-oriented topics including clinical characteristics and treatment of histiocytic disorders in both children and adults; genetics of familial HLH; secondary HLH (including malignancy, infection); the role of hematopoietic cell transplant in pediatric and adult HLH; and more- Provides in-depth clinical reviews on hemophagocytic syndromes, offering actionable insights for clinical practice- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews

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Table of Contents

Molecular Pathogenesis of the Histiocytic and Dendritic Cell Neoplasms
Genomic Alterations in Langerhans Cell Histiocytosis
Clinical Characteristics and Treatment of Histiocytic Disorders in Children
Genetics of Familial Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Characteristics and Treatment of Familial Hemophagocytic Lymphohistiocytosis
Recognizing and Managing Secondary Hemophagocytic Lymphohistiocytosis in Adults: A Practical Clinical Guide
Macrophage Activation Syndrome: Not Just for Rheumatologists Anymore
Immune Effector Cell-associated Hemophagocytic Lymphohistiocytosis-like Syndrome (IEC-HS)
Role of Hematopoietic Cell Transplantation in Pediatric and Adult Hemophagocytic Lymphohistiocytosis-Remaining Unknowns and Challenges

Authors

Nancy Berliner Brigham and Women's Hospital
Professor of Medicine
Harvard Medical School
Boston, MA. Barbara A. Degar Medical Director, Inpatient Oncology, Boston Children's Hospital, Assistant Professor in Pediatrics, Harvard Medical School, Boston, MA, USA.