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Advances in Systemic Therapy for Lung Cancer, An Issue of Thoracic Surgery Clinics. The Clinics: Internal Medicine Volume 36-1

  • Book

  • December 2025
  • Elsevier Health Science
  • ID: 6252330
In this issue of Thoracic Surgery Clinics, guest editors Drs. Brendon M. Stiles and Tamar B. Nobel bring their considerable expertise to the topic of Advances in Systemic Therapy for Lung Cancer. Recent advances in systemic therapies, marked by ongoing clinical trials and new drug approvals, have revolutionized the treatment landscape, offering new hope for patients with lung cancer. This issue features articles by top experts who explore various topics including novel neoadjuvant and adjuvant clinical trials that could redefine standard care protocols.- Contains 13 relevant, practice-oriented topics including neoadjuvant immunotherapy alone; neoadjuvant chemotherapy and immunotherapy; adjuvant immunotherapy; update on biomarkers and drug approvals for patients with stage IV NSCLC; role of surgery for patients with metastatic NSCLC; and more- Provides in-depth articles on advances in systemic therapy for lung cancer, offering actionable insights for clinical practice- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews

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Table of Contents

Neoadjuvant Immunotherapy
Neoadjuvant Chemoimmunotherapy
Neoadjuvant Tyrosine Kinase Inhibitors
Surgical Challenges After Neoadjuvant Therapy
Adjuvant Immunotherapy in Lung Cancer: Foundational Successes and Future Directions
The Evolving Role of Adjuvant TKI in Lung Cancer: From Historical Trials to Future Strategies National Cancer Center Hospital East, Japan
Neoadjuvant, Adjuvant, or Both? Optimizing Perioperative Systemic Therapy in Lung Cancer
Adding Immunotherapy and Targeted Therapy to Chemoradiotherapy for Non-small Cell Lung Cancer
Update on Neoadjuvant and Adjuvant Trials
Advances in Systemic Therapy for Lung Cancer: Update on Biomarkers and Novel Drugs for Patients with Stage IV Non-Small Cell Lung Cancer (NSCLC)
Role of Surgery for Patients with Metastatic Non-small Cell Lung Cancer

Authors

Brendon M. Stiles Chief, Division of Thoracic Surgery and Surgical Oncology, Associate Director, Surgical Services, Montefiore-Einstein Comprehensive Cancer Center, Professor of Cardiovascular & Thoracic Surgery Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA. Tamar B. Nobel Assistant Professor, Cardiothoracic and Vascular Surgery and Epidemiology and Population Health Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.