Mass Spectrometry in Drug Metabolism and Pharmacokinetics

  • ID: 705532
  • Book
  • 390 Pages
  • John Wiley and Sons Ltd
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Advanced mass spectrometry techniques to support your drug discovery and development research

Inside this book are a host of practical tools and techniques that enable you to fully leverage the capabilities of mass spectrometry in order to get the most out of drug metabolism and pharmacokinetics studies. You′ll learn the latest applications for determining how a drug is absorbed, distributed, metabolized, and excreted by the body.

Logically organized, Mass Spectrometry in Drug Metabolism and Pharmacokinetics starts off with an overview of the role of mass spectrometry in drug discovery and development. It then shows you how to perform routine applications before introducing you to sophisticated tools and techniques for solving complex drug metabolism and pharmacokinetics problems. Throughout the book, the main focus is on the use of LC–MS and MALDI–MS.

Each chapter has been written by one or more leading experts who share their own first–hand laboratory experience. You′ll gain a wealth of tips for performing successful analyses as well as avoiding common pitfalls. Moreover, the book is packed with features that help you grasp new concepts quickly and put your knowledge into practice, including:

  • Figures and illustrations to help you understand how to perform specific techniques and applications

  • Charts and tables that serve as quick summaries and reference guides

  • Coverage of the latest tested–and–proven techniques

  • References leading to the primary literature in the field

Carefully edited to ensure thoroughness and a uniform standard of quality, this book is sure to help you advance your own important drug research efforts.

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Preface vii

About the Editor ix

Contributors xi

1. Evolving Role of Mass Spectrometry in Drug Discovery and Development 1Dil M. Ramanathan and Richard M. LeLacheur

2. Quantitative Bioanalysis in Drug Discovery and Development: Principles and Applications 87Ayman El–Kattan, Chris Holliman, and Lucinda H. Cohen

3. Quadrupole, Triple–Quadrupole, and Hybrid Linear Ion Trap Mass Spectrometers for Metabolite Analysis 123Elliott B. Jones

4. Applications of Quadrupole Time–of–Flight Mass Spectrometry in Reactive Metabolite Screening 159Jose M. Castro–Perez

5. Changing Role of FTMS in Drug Metabolism 191Petia A. Shipkova, Jonathan L. Josephs, and Mark Sanders

6. High–Resolution LC–MS–Based Mass Defect Filter Approach: Basic Concept and Application in Metabolite Detection 223Haiying Zhang, Donglu Zhang, Mingshe Zhu, and Kenneth L. Ray

7. Applications of High–Sensitivity Mass Spectrometry and Radioactivity Detection Techniques in Drug Metabolism Studies 253Wing W. Lam, Cho–Ming Loi, Angus Nedderman, and Don Walker

8. Online Electrochemical–LC–MS Techniques for Profiling and Characterizing Metabolites and Degradants 275Paul H. Gamache, David F. Meyer, Michael C. Granger, and Ian N. Acworth

9. LC–MS Methods with Hydrogen/Deuterium Exchange for Identification of Hydroxylamine, N–Oxide, and Hydroxylated Analogs of Desloratadine 295Natalia A. Penner, Joanna Zgoda–Pols, Ragu Ramanathan, Swapan K. Chowdhury, and Kevin B. Alton

10. Turbulent–Flow LC–MS: Applications for Accelerating Pharmacokinetic Profiling and Metabolite Identification 311Joseph L. Herman and Joseph M. Di Bussolo

11. Desorption Ionization Techniques for Quantitative Analysis of Drug Molecules 341Jason S. Gobey, John Janiszewski, and Mark J. Cole

12. MALDI Imaging Mass Spectrometry for Direct Tissue Analysis of Pharmaceuticals 359Yunsheng Hsieh and Walter A. Korfmacher

Index 383

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“All in all, the book delivers on its promises to introduce and review the current art of mass spectrometry for the related disciplines of drug metabolism and pharmacokinetics. I highly recommend it.” (JACS Book Reviews, June 2009)

“In comparison to other books on mass spectrometry, this one not only provides both the basic and latest knowledge in mass spectrometry, but integrates the theory with applications to drug metabolism and pharmacokinetics.” (Doody′s, April 2009)

"Mass Spectrometry in Drug Metabolism and Pharmacokinetics is a valuable and interesting resource for a broad readership, including scientists starting to work in DMPK as well as undergraduate and graduate students getting involved in drug discovery and characterization by means of MS. A wealth of information is provided and all of the contributing authors have done an excellent job in explaining and outlining particular aspects of MS–based tools in DMPK ... the book is highly recommended reading." (Journal of the American Society for Mass Spectrometry, March 2009)

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