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Cell Line Development Services Global Market - Forecast To 2030

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    Report

  • 220 Pages
  • December 2022
  • Region: Global
  • IQ4I Research & Consultancy Pvt. Ltd
  • ID: 5703429
Description Jump to:

Cell lines are one the major tools used in research for studying the normal physiology and biochemistry of cells, the effects of drugs and toxic compounds on the cells, drug screening and development and large scale manufacturing of biological compounds. Cell culture is the process by which cells are grown under controlled conditions derived from microbial or animal cells. Cell lines are subculture of primary culture also known as sub-clone. Cell lines derived from primary cultures have a limited life span, after subsequent cultures, cells with the highest growth capacity dominate which are selected for further cell development. Primary cells are cells that are cultured directly from a subject and have a limited lifespan. An immortalized cell line can proliferate indefinitely either through random mutation or deliberate modification which are useful especially for production of therapeutics.

The cell line development service market is expected to grow at a double digit CAGR from 2022 to 2030 to reach $2,093.2 million by 2030. Increasing trend of biologics outsourcing and increasing approval and demand for biologics and biosimilars are driving the market. While, growing incidence rate of oncology, autoimmune disorders, infectious diseases & genetic disorders, growth in research activities related to the diseases and also recombinant cell lines for the production recombinant biopharmaceutical proteins and technological advancements in cell line engineering (gene editing tools) & cell line development technologies, screening technologies and process development are giving immense growth opportunities for the market. However, tedious procedure involved in the development of stable cell lines and high risk of contamination are restraining the market. Furthermore, stringent and complex regulations and the high cost and technical requirement to adhere to accreditations such as GMP are posing threat to the industry.

Cell line development service global market is classified based on the expression system, cell line type, application and geography. Based on expression system, cell line development service global market is segmented into microbial, mammalian and others. Among these, mammalian expression system is accounted for the highest revenue of in 2022 and is expected to grow at a double digit CAGR from 2022 to 2030 due to increasing approval of novel biologics drugs with mammalian expression system, ability to add human-like post-translational modifications to the complex protein therapeutics and launch of advanced mammalian expression system to improve biologics development.

Based on the cell line type, global cell line development service market is segmented into CHO, Mouse Myeloma (NS0; Sp2/0), Human Embryonic Kidney (HEK), Baby Hamster Kidney (BHK), Hybridoma, Human Embryonic Retina (PER.C6) and others. Among these, CHO cell line accounted for the highest revenue in 2022 and is expected to grow at an early teen CAGR from 2022 to 2030 due to increasing approval of biologics which are developed from CHO cell lines, development of advanced CHO cell line development platform by the CDMO and collaboration to offer CHO based CLD services.

Cell lines are essential for a wide range of applications including gene function studies, drug discovery assays, the production of biotherapeutics and diagnostics. Based on application, cell line development service global market is segmented into research, bioproduction and diagnostics. Among these, bioproduction segment accounted for the highest revenue in 2022 and is expected to grow at a double digit CAGR from 2022 to 2030 due higher demand of biologics & biosimilars for therapeutics application and increasing collaboration between the companies for the development & production of biotherapeutics using cell line development platforms. Based on the geography, cell line development service global market is segmented into North America, Europe, Asia-Pacific and Rest of the world. North America commanded the highest revenue in 2022. The market is expected to grow at a high single digit CAGR of from 2022 to 2030. Asia-Pacific region is expected to grow at a early teen CAGR during the forecasted period.

Most of the CDO or CDMO offering cell line development services to generate cell lines for bio production, research or diagnostic purposes. Companies are developing advanced platforms to generate high-performance, highly stable, production cell lines. For instance, in October 2022, Aragen Life Sciences has launched its RapTr 2022 cell line development platform.RapTr2022 offers a 33% reduction in CLD timelines and delivers increased titres up to 6g/l. The RapTr CLD services include the proven CHO-DG44 and CHO-GS cell lines and proprietary vector combinations with an innovative clone selection process.

Newer technologies such as automated screening methods, advanced cell line engineering techniques, enhanced expression systems, improved process monitoring, and use of single use bioreactor & micro bioreactor for small scale bioproduction are further expected to provide this market with lucrative future growth opportunities. Screening of high producing cell clone one of important step in cell line development. Automated screening is used for screening of a large number of clones to identify the small subset of high producing clones. Nanofluidic technologies offer a promising solution to further miniaturize cell culture processes. One such technology platform has been developed by Berkeley Lights. CDMO are adopting advanced clone selection technologies (such as omics, optofluidics, and siRNA) to enhance their cell line development services offerings. Apart from optiofludics technologies, CDMO are adding advanced single cell sorting technologies to expand their offerings.

The ability of non-human mammalian expression systems to produce non-human post translational modifications like N-glycolylneuraminic acid (NGNA) and alpha1,3-galactose (α-gal) that can affect the stability, biologic activity, immunogenicity and clearance of the biologic products produced from them has led to a gradual shift of focus to the equally productive and more valuable niche human expression systems.

The major players in cell line development service global market include AGC Inc. (AGC Biologics) (Japan), Boehringer Ingelheim International GmbH (Germany), Catalent Inc. (U.S.), Charles River Laboratories International Inc. (U.S.), Fujifilm Holdings Corporation (Japan), Genscript Biotech Corporation (U.S.), JSR Corporation (Japan), Lonza Group Ltd. (Switzerland), Samsung Biologics Co. Ltd. (South Korea), Thermofisher Scientific Inc. (Patheon N.V.) (Brammer Bio) (U.S.), Wuxi Biologics (China), Sartious Group (Germany), Merck KGaA (Germany), Eurofins Scientific S.E ((Luxembourg).

Table of Contents


1 Executive Summary
2 Market Dynamics
2.1 Drivers and Opportunities
2.1.1 Increasing Trend of Outsourcing
2.1.2 Increasing Approvals and Demand for Biologics and Biosimilars
2.1.3 Increasing Incidence and Prevalence of Chronic, Communicable and Autoimmune Diseases
2.1.4 Advanced Technologies for Screening and Cell Line Engineering
2.2 Restraints and Threats
2.2.1 Tedious Procedures Associated with the Development of Stable Cell Lines
2.2.2 Risk of Contamination Associated with Cell Line Development
2.2.3 Compliance with Stringent Regulatory Guidelines
2.2.4 High Cost and Technical Requirements to Obtain Gmp Certifications

3 Cell Line Development
3.1 Cell Line Construction
3.2 Host Cell Line Engineering Expression System
3.3 Expression Vector and Host Cell Line Engineering
3.4 Transient Gene Expression
3.5 Stable Cell Line Development
3.6 Screening
3.7 Upstream Process Development

4 Host Celllines5 Cell Line Development Global Market, Based on Region
6 Cell Line Development Services Market, Based on Expression System
6.1 Mammalian Expression Systems
6.2 Microbial Expression Systems
6.3 Others (Insect and Plant Cell)

7 Cell Line Development Services, Based on Cell Line Type
7.1 Cho
7.2 Murine/Mouse Myeloma (Ns0, Sp2/0)
7.3 Baby Hamster Kidney (Bhk) Cells
7.4 Human Embryonic Kidney (Hek) Cells
7.5 Human Embryonic Retinal Cells (Per.C6)
7.6 Hybridoma
7.7 Others (E.Coli, Yeast, Insect Cell, Vero Ht-1080, Hela, Cap, Hkb-11, Huh-7)

8 Cell Line Development Services, Based on Applications
8.1 Research
8.2 Bioproduction
8.3 Diagnostics

9 Cell Banking and Characterization Services
9.1 Cell Banking Services
9.2 Cell Line Characterization Services

10 Market Share Analysis
10.1 Key Developments
10.1.1 Agreement, Collaboration and Partnership
10.1.2 New Technology, Product and Service Launch
10.1.3 Expansion
10.1.4 Other Developments

11 Company Profiles
11.1 Agc Inc.
11.1.1 Overview
11.1.2 Financials
11.1.3 Service Portfolio
11.1.4 Key Developments
11.1.5 SWOT Analysis
11.2 Boehringer Ingelheim International Gmbh
11.2.1 Overview
11.2.2 Financials
11.2.3 Service Portfolio
11.2.4 Key Developments
11.2.5 SWOT Analysis
11.3 Catalent Inc.
11.3.1 Overview
11.3.2 Financials
11.3.3 Service Portfolio
11.3.4 Key Developments
11.3.5 SWOT Analysis
11.4 Charles River Laboratories
11.4.1 Overview
11.4.2 Financials
11.4.3 Service Portfolio
11.4.4 Key Developments
11.4.5 SWOT Analysis
11.5 Emergent Biosolutions Inc.
11.5.1 Overview
11.5.2 Financials
11.5.3 Service Portfolio
11.5.4 Key Developments
11.5.5 SWOT Analysis
11.6 Eurofins Scientific S.E.
11.6.1 Overview
11.6.2 Financials
11.6.3 Service Portfolio
11.6.4 Key Developments
11.6.5 SWOT Analysis
11.7 Fujifilm Holdings Corporation (Fujiflm Diosynth Biotechnol0Gies)
11.7.1 Overview
11.7.2 Financials
11.7.3 Service Portfolio
11.7.4 Key Developments
11.7.5 SWOT Analysis
11.8 Genscript Biotech Corporation
11.8.1 Overview
11.8.2 Financials
11.8.3 Service Portfolio
11.8.4 Key Developments
11.8.5 SWOT Analysis
11.9 Jsr Corporation
11.9.1 Overview
11.9.2 Financials
11.9.3 Service Portfolio
11.9.4 Key Developments
11.9.5 SWOT Analysis
11.1 Lonza Group Ltd.
11.10.1 Overview
11.10.2 Financials
11.10.3 Service Portfolio
11.10.4 Key Developments
11.10.5 SWOT Analysis
11.11 Merck Kga
11.11.1 Overview
11.11.2 Financials
11.11.3 Product Portfolio
11.11.4 Key Developments
11.11.5 SWOT Analysis
11.12 Samsung Biologics Co. Ltd.
11.12.1 Overview
11.12.2 Financials
11.12.3 Service Portfolio
11.12.4 Key Developments
11.12.5 SWOT Analysis
11.13 Sartorius Group
11.13.1 Overview
11.13.2 Financials
11.13.3 Service Portfolio
11.13.4 Key Developments
11.13.5 SWOT Analysis
11.14 Thermofisher Scientific Inc.
11.14.1 Overview
11.14.2 Financials
11.14.3 Service Portfolio
11.14.4 Key Developments
11.14.5 SWOT Analysis
11.15 Wuxi Biologics
11.15.1 Overview
11.15.2 Financials
11.15.3 Service Portfolio
11.15.4 Key Developments
11.15.5 SWOT Analysis

List of Tables
Table 1 Approved Biologics and Cell Line Type (2015-2021)
Table 2 Number of Approved Biologics by Cell Line Type (2014-2020)
Table 3 Cell Line Development Services Global Market, Based on Region, (2021-2030) ($Mn)
Table 4 Cell Line Development Services Global Market, Based on Expression System, (2021-2030) ($Mn)
Table 5 Cell Line Development Services Global Market, Based on Cell Type, (2021-2030) ($Mn)
Table 6 Cell Line Type of Some Approved Biologics Modalities and Cell Line Type
Table 7 Cell Line Development Services Global Market, Based on Application, (2021-2030) ($Mn)
Table 8 Cell Line Development Technologies
Table 9 Cell Line Development Services Cost
Table 10 Agreements (2020 -2022)*
Table 11 New Technology, Product and Service Launch (2020-2022)
Table 12 Expansion (2020-2022)
Table 13 Others (2020-2022)
Table 14 Comparison Matrix of Cell Line Development Players and Services Offered
Table 15 Agc Inc.: Total Revenue and R&D Expenses, (2020-2022) (Q3) ($Mn)
Table 16 Agc Inc.: Total Revenue, by Segments, (2020-2022) (Q3) ($Mn)
Table 17 Agc Inc.: Chemicals Revenue, by Sub-Segments, (2020-2022) (Q3) ($Mn)
Table 18 Agc Inc.: Total Revenue, by Geography, (2020-2022) (Q3) ($Mn)
Table 19 Boehringer Ingelheim: Total Revenue and R&D Expenses, (2019-2021) ($Mn)
Table 20 Boehringer Ingelheim: Total Revenue, by Segments, (2019-2021) ($Mn)
Table 21 Boehringer Ingelheim: Total Revenue, by Geography, (2019-2021) ($Mn)
Table 22 Catalent Inc: Total Revenue and R&D Expenses (2021-2023) (Q1) ($Mn)
Table 23 Catalent Inc: Total Revenue, by Segment, (2021-2023) (Q1) ($Mn)
Table 24 Catalent Inc: Total Revenue, by Geogrpahy, (2021-2023) (Q1) ($Mn)
Table 25 Charles River Laboratories: Total Revenue and R&D Expenses, (2020-2022) (Q3)($Mn)
Table 26 Charles River Laboratories: Total Revenue, by Segments, (2020-2022) (Q3) ($Mn)
Table 27 Charles River Laboratories: Total Revenue, by Geography, (2020-2022) (Q3) ($Mn)
Table 28 Emergent Biosolutions Inc : Total Revenue and R & D Expenses (2020-2022) (Q3) ($Mn)
Table 29 Emergent Biosolutions Inc : Total Revenue by Segment (2020-2022) (Q3) ($Mn)
Table 30 Eurofins Scientific S.E. : Total Revenue and R & D Expenses (2020-2022) (Q3) ($Mn)
Table 31 Eurofins Scientific S.E : Total Revenue, by Geography, (2020-2021) (Q3) ($Mn)
Table 32 Fujifilm Holdings Corporation: Total Revenue and R&D Expenses, (2020-2022) (Q2) ($Mn)
Table 33 Fujifilm Holdings Corporation: Total Revenue, by Segments, (2020-2022) (Q2)($Mn)
Table 34 Fujifilm Holding Corporation: Total Revenue, by Geography, (2020-2022) (Q2) ($Mn)
Table 35 Genscript Biotech Corporation: Total Revenue and R&D Expenses, (2020-2022) (Q2)($Mn)
Table 36 Genscript Biotech Corporation: Total Revenue, by Segments, (2020-2022) (Q2) ($Mn)
Table 37 Genscript Biotech Corporation: Total Revenue, by Geography, (2020-2022) (Q2) ($Mn)
Table 38 Jsr Corporation: Total Revenue and R&D Expenses, (2021-2023) (Q2) ($Mn)
Table 39 Jsr Corporation: Total Revenue, by Segments, (2021-2023) (Q2) ($Mn)
Table 40 Jsr Corporation: Total Revenue, by Geography, (2021-2023) (Q2) ($Mn)
Table 41 Lonza Group: Total Revenue & R&D Expenses (2020 -2022) (Q2) ($Mn)
Table 42 Lonza Group: Total Revenue, by Segment, (2020 -2022) (Q2) ($Mn)
Table 43 Lonza Group: Total Revenue, by Geography (2020 -2022) (Q2) ($Mn)
Table 44 Merck Kga: Total Revenue and R&D Expenses, (2020-2022) (Q3) ($Mn)
Table 45 Merck Kga: Total Revenue, by Segments, (2020-2022) (Q3) ($Mn)
Table 46 Merck Kga: Total Revenue, by Sub - Segments, (2020-2022) (Q3) ($Mn)
Table 47 Merck Kga: Total Revenue, by Geography, (2020-2022) (Q3) ($Mn)
Table 48 Samsung Biologics Co: Total Revenue (2020-2022) (Q3) ($Mn)
Table 49 Sartorius : Total Revenue and R & D Expenses (2020-2022) (Q3) ($Mn)
Table 50 Sartorius: Total Revenue, by Segments, (2020-2022) (Q3) ($Mn)
Table 51 Sartorius: Total Revenue, by Geography, (2020-2022) (Q3) ($Mn)
Table 52 Thermo Fisher Scientific Inc.: Total Revenue and R&D Expenses (2020-2022) (Q3) ($Mn)
Table 53 Thermo Fisher Scientific Inc.: Total Revenue, by Segment, (2020-2022) (Q3) ($Mn)
Table 54 Thermo Fisher Scientific Inc.: Total Revenue, by Geography (2020-2022)(Q3) ($Mn)
Table 55 Wuxi Biologics: Total Revenue and R&D Expenses, (2020-2022) (Q2)($Mn)
Table 56 Wuxi Biologics: Total Revenue, by Segments, (2020-2022) (Q2) ($Mn)
Table 57 Wuxi Biologics: Total Revenue, by Geography, (2020-2022) (Q2) ($Mn)

List of Figures
Figure 1 Market Dynamics of Cell Line Development
Figure 2 Number of Approved Biologics by Cell Line Type (2015-2021)
Figure 3 Cell Line Development Services Global Market Share, Based on Region, (2022 vs 2030) (%)
Figure 4 Cell Line Development Services Global Market, Based on Expression System, (2022 V/S 2030) ($Mn)
Figure 5 Expression Systems of Some Approved Biologics (2015 - 2021)
Figure 6 Cell Line Development Services Global Market, Based on Cell Type, (2022 V/S 2030) ($Mn)
Figure 7 Cell Line Type of Some Approved Biologics (No's) (2015-2021)
Figure 8 Cell Line Type of Some Approved Biologics Modalities and Cell Line Type
Figure 9 Cell Line Development Services Global Market Revenue, Based on Application, (2022 V/S 2030) ($Mn)
Figure 10 Cell Line Development Servcies Global Market Share, by Leading Players (2022) (%)
Figure 11 Key Developments of Cell Line Development Services Market Players, (2020-2022)
Figure 12 Overview: Agc Inc.
Figure 13 SWOT: Agc Inc.
Figure 14 Boehringer Ingelheim Revenue Overview
Figure 15 SWOT: Boehringer Ingelheim
Figure 16 Overview: Catalent Inc.
Figure 17 SWOT: Catalent Inc.
Figure 18 Overview: Charles River Laboratories
Figure 19 SWOT: Charles River Laboratories
Figure 20 Overview: Emergent Biosolutions Inc
Figure 21 SWOT: Emergent Biosolutions
Figure 22 Overview: Eurofins Scientific
Figure 23 SWOT: Eurofins Scientific
Figure 24 Overview: Fujifilm Holding Corporation
Figure 25 SWOT: Fujifilm Holding Corporation
Figure 26 Overview: Genscript Biotech Corporation
Figure 27 SWOT: Genscript Biosciences Corporation
Figure 28 Overview: Jsr Corporation
Figure 29 SWOT: Jsr Corporation
Figure 30 Overview: Lonza Group
Figure 31 SWOT: Lonza Group
Figure 32 Overview: Merck Kga
Figure 33 SWOT: Merck Kgaa
Figure 34 SWOT: Samsung Biologics
Figure 35 Overview: SartoriUS
Figure 36 SWOT: Sartorius Group
Figure 37 Overview: Thermofisher Scientific
Figure 38 SWOT: Thermo Fisher Scientific
Figure 39 Overview: Wuxi Biologics
Figure 40 SWOT: Wuxi Biologics

Samples

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Companies Mentioned

  • 3P Biopharmaceuticals
  • 53 biologics
  • A & G Pharmaceutical Inc (Precision Antibody)
  • Abzena PLC
  • AGC Inc. (AGC Biologics)
  • Anthem Biosciences Private Limited.
  • Applied StemCell Inc.
  • Aragen Bioscience
  • Avid Bioservices Inc
  • Biologics International Corp
  • Bioneer A/S
  • Biovian Oy
  • Boehringer Ingelheim International GmbH
  • BPS Bioscience, Inc.
  • Canton Biologics Co., Ltd
  • Catalent Inc.
  • Celonic AG
  • Charles River Laboratories International Inc.
  • CJ Cheiljedang (Batavia Biosciences B.V)
  • Creative Biolabs
  • Curia
  • EirGenix, Inc.
  • Emergent Biosciences
  • Eurofins Scientific S.E
  • Evotec
  • ExcellGene SA
  • Fujifilm Holdings Corporation (Fujifilm Diosynth Biotechnologies)
  • Fusion Antibodies
  • Genscript Biotech Corporation
  • Great Bay Bio
  • GVK Biosciences Private Limited
  • Hepalink (Cytovance Biologics & SPL)
  • JSR Corporation [JSR Life Sciences, LLC (KBI biopharma, Selexis SA, CrownBio)]s
  • Kemwell Biopharma
  • LFB Biomanufacturing
  • Lonza Group Ltd.
  • Matica Biotechnology, Inc. (Matica Bio)
  • Merck KGaA
  • Minapharm Pharmaceuticals (Egypt)(ProBiogen AG)
  • Mycenax
  • Northway BiotechPharma
  • Perkin Elmer
  • Polpharma Biologics S.A
  • Premas Biotech Pvt Ltd
  • Rentschler Biopharma SE
  • Samsung Biologics Co. Ltd.
  • Sartious Group
  • Sino Biological Inc
  • Syd labs
  • Syngene International Ltd.
  • Thermofischer Scientific Inc.
  • Trenzyme GmbH
  • Wuxi Biologics Inc.

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