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Selumetinib is a drug used to treat advanced thyroid cancer. It is a type of targeted therapy, meaning it works by targeting specific molecules involved in the growth and spread of cancer cells. Selumetinib works by blocking the activity of a protein called MEK, which is involved in the growth and spread of cancer cells. It is used in combination with other drugs to treat advanced thyroid cancer that has spread to other parts of the body. Selumetinib is approved by the US Food and Drug Administration (FDA) for the treatment of advanced thyroid cancer. It is also approved in the European Union and other countries. Selumetinib is marketed by AstraZeneca under the brand name Mekinist. Other companies that market selumetinib include Merck, Pfizer, and Novartis. Show Less Read more