* Presents information on the major animal models used in eye research including invertebrates and vertebrates
* Provides researchers with information needed to choose between model organisms
* Includes an introductory chapter on the different types of eyes, stressing possible common molecular machinery
Eye diversity in the animal Kingdom
Photosensitivity: Melanopsin, opsins
Cyanobacteria, protozoa: photoreception, rhodopsin
Platynereis: as a model for lochotrophozoa
Drosophila: Superb system for genetics, genetic manipulation.
Planaria: As a model for invertebrate eye regeneration with emphasis on stem cells.
Fish/cavefish: As a model for retina regeneration and lens development. Zebrafish is accessible for genetic manipulation by morpholinos, medaka accessible for genetic studies.
Xenopus: As a model for retina (via progenitor cells) and lens regeneration (by transdifferentiation from the cornea). Also an important model for transgenic studies in amphibia.
Newt: As a model for retina and lens regeneration in adult vertebrates by transdifferentiation. Xenopus and Newt could be combined as a chapter on amphibia.
Chick: Excellent system for retina regeneration (both transdifferentiation and stem cells) as well for lens and retina development. RCAS transgenesis is an important asset of this system.
Mouse: Knock-out and transgenesis technologies make this animal the best mammal to study eye development.
Rabbit: Model for cataract surgery.
A chapter could be devoted to animals where we see recruitment of crystallins to perform other roles
Animal models for physiology of the eye