The Basal Ganglia comprise a group of forebrain nuclei that are interconnected with the cerebral cortex, thalamus and brainstem. Basal ganglia circuits are involved in various functions, including motor control and learning, sensorimotor integration, reward and cognition. The importance of these nuclei for normal brain function and behavior is emphasized by the numerous and diverse disorders associated with basal ganglia dysfunction, including Parkinson's disease, Tourette's syndrome, Huntington's disease, obsessive-compulsive disorder, dystonia, and psychostimulant addiction.
The Handbook of Basal Ganglia provides a comprehensive overview of the structural and functional organization of the basal ganglia, with special emphasis on the progress achieved over the last 10-15 years. Organized in six parts, the volume describes the general anatomical organization and provides a review of the evolution of the basal ganglia, followed by detailed accounts of recent advances in anatomy, cellular/molecular, and cellular/physiological mechanisms, and our understanding of the behavioral and clinical aspects of basal ganglia function and dysfunction.
- Synthesizes widely dispersed information on the behavioral neurobiology of the basal ganglia, including advances in the understanding of anatomy, cell-molecular and cell-physiological mechanisms, and behavioral/clinical aspects of function and dysfunction
- Features a truly international cast of the preeminent researchers in the field
- Fully explores the clinically relevant impact of the basal ganglia on various psychiatric and neurological diseases
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Part A: The Basal Ganglia System and its Evolution Chapter 1. The Neuroanatomical Organization of the Basal Ganglia Charles R. Gerfen Chapter 2. The Conservative Evolution of the Vertebrate Basal Ganglia A. Reiner Chapter 3. Cell Types in the Different Nuclei of the Basal Ganglia Dorothy E. Oorschot Chapter 4. Neurotransmitter Receptors in the Basal Ganglia Piers C. Emson, Henry Waldvogel and Richard Faull Part B: Anatomy and Physiology of the Striatum Chapter 5. The Striatal Skeleton: Medium Spiny Projection Neurons and their Lateral Connections Dietmar Plenz and Jeffery R. Wickens Chapter 6. D1 and D2 Dopamine Receptor Modulation of Striatal Glutamatergic Signaling in Striatal Medium Spiny Neurons D. James Surmeier, Michelle Day, Tracy Gertler, Savio Chan and Weixing Shen Chapter 7. The Cholinergic Interneurons of the Striatum: Intrinsic Properties Underlie Multiple Discharge Patterns Joshua A. Goldberg and Charles J. Wilson Chapter 8. GABAergic Interneurons of the Neostriatum James M. Tepper Chapter 9. Endocannabinoid Signaling in the Striatum David M. Lovinger, Margaret I. Davis and Rui M. Costa Chapter 10. Nitric Oxide Signaling in the Striatum Anthony R. West Chapter 11. Adenosine-Dopamine Receptor Interaction Micaela Morelli, Simola Nicola, Popoli Patrizia and Carta Anna R. Chapter 12. Regulation of Corticostriatal Synaptic Plasticity in Physiological and Pathological Conditions Massimiliano Di Filippo and Paolo Calabresi Part C: Anatomy and Physiology of Globus Pallidus, Subthalamic Nucleus and Substantia Nigra Chapter 13. Organization of the Globus Pallidus Hitoshi Kita Chapter 14. Projections from Pallidum to Striatum Pieter Voorn Chapter 15. The Subthalamic Nucleus: From in vitro to in vivo Mechanisms Stephane Charpier, Corinne Beurrier and Jeanne T. Paz Chapter 16. Neurophysiology of Substantia Nigra Dopaminergic Neurons: Modulation by GABAergic Afferents James M. Tepper Chapter 17. Regulation of Extracellular Dopamine: Release and Reuptake David Sulzer, Hui Zhang, Marianne Benoit-Marand, and Francois Gonon Part D: Network Integration Chapter 18. Organization of Corticostriatal Projection Neuron Types Anton Reiner Chapter 19. Gating of Cortical Input to the Striatum Jeffery R. Wickens and Gordon W. Arbuthnott Chapter 20. Organization of Prefrontal-Striatal Connections Henk J. Groenewegen and Harry B.M. Uylings Chapter 21. Gating of Limbic Input to the Ventral Striatum Patricio O'Donnell Chapter 22. Anatomical and Functional Organization of the Thalamostriatal Systems Yoland Smith, Adriana Galvan, Dinesh Raju and Thomas Wichmann Chapter 23. Subcortical Connections of the Basal Ganglia David I.G. Wilson, Philip Winn and Peter Redgrave Chapter 24. Integrative Networks across Basal Ganglia Circuits Suzanne N. Haber Chapter 25. Synchronous Activity in Basal Ganglia-Cortical Circuits J.R. Walters and D.A. Bergstrom Part E: Molecular Signaling in the Basal Ganglia Chapter 26. Second Messenger Cascades Stephanie E. Bronson and Christine Konradi Chapter 27. Neurotransmitter Regulation of Basal Ganglia Gene Expression Kristen A. Keefe and Kristen A. Horner Chapter 28. D1-Dopamine Receptor Supersensitivity in the Striatum Charles R. Gerfen Chapter 29. Psychostimulant-Induced Gene Regulation in Cortico-Striatal Circuits Heinz Steiner Chapter 30. Chromatin Remodeling: Role in Neuropathologies of the Basal Ganglia Jocelyne Caboche, Emmanuel Roze, Karen Brami-Cherrier and Sandrine Betuing Part F: Basal Ganglia Function and Dysfunction Chapter 31. Phasic Dopamine Signaling and Basal Ganglia Function Peter Redgrave, Veronique Coizet and John Reynolds Chapter 32. Basal Ganglia-Mediated Motor Learning M.G. Packard Chapter 33. Drug Addiction: The Neural and Psychological Basis of a Compulsive Incentive Habit David Belin and Barry J. Everitt Chapter 34. Environmental Contributions to Parkinson's disease: Cross Talk between Environmental Factors and Gene Defects Gloria E. Meredith and Susan Totterdell Chapter 35. Alterations in Corticostriatal Synaptic Function in Huntington's and Parkinson's Diseases Carlos Cepeda, Nigel S. Bamford, Véronique M. André and Michael S. Levine Chapter 36. Molecular Mechanisms of L-DOPA-Induced Dyskinesia M. Angela Cenci Chapter 37. Compensatory Mechanisms in Experimental and Human Parkinsonism: Potential for New Therapies Erwan Bezard, Grégory Porras, Javier Blesa and José A. Obeso Chapter 38. Pathological Synchrony of Basal Ganglia-Cortical Networks in the Systemic MPTP Primate Model of Parkinson's Disease Hagai Bergman, Adam Zaidel, Boris Rosin, Maya Slovik, Michal Rivlin-Etzion, Shay Moshel and Zvi Israel Chapter 39. Deep-Brain Stimulation for Neurologic and Psychiatric Disorders Mahlon R. DeLong and Thomas Wichmann
Heinz Steiner is Professor and Chair of the Department of Cellular and Molecular Pharmacology at the Chicago Medical School/Rosalind Franklin University of Medicine and Science in Chicago, Illinois. Dr. Steiner is an expert on the functional organization of the basal ganglia and related brain systems. His research focuses, in particular, on the role of the neurotransmitter dopamine in the regulation of basal ganglia-cortical interactions; his recent investigations examine how chronic enhancement of dopamine actions produce changes in gene regulation, and how these molecular alterations affect basal ganglia function and behavior. He has been the North America Regional Editor for the journal Basal Ganglia since 2011.
Tseng, Kuei Y.
Kuei Y. Tseng is Associate Professor in the Department of Cellular and Molecular Pharmacology at the Chicago Medical School/Rosalind Franklin University of Medicine and Science in Chicago, Illinois. Dr. Tseng's research focuses on the neural bases of Parkinson's disease, particularly the effects of dopamine loss within the cortico-basal ganglia circuitry and the mechanisms underlying information processing in the brains of individuals affected by Parkinson's disease. He is the editor of two books on the cortex.