Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine.
- Broad-based up-to-date resource for the dynein class of molecular motors
- Chapters written by world experts in their topics
- Numerous well-illustrated figures and tables included to complement the text, imparting comprehensive information on dynein composition, interactions, and other fundamental features
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Table of Contents
I History and Evolution
Chapter 1 Discovery of Dynein and its Properties : A Personal Account
Chapter 2 Evolutionary Biology of Dyneins
II Structure and Mechanics of Dynein Motors
Chapter 3 The AAA+ Powerhouse-Trying to Understand How it Works
Chapter 4 Dynein Motor Mechanisms
Chapter 5 Structural Analysis of Dynein Intermediate and Light Chains
Chapter 6 Biophysics of Dynein In Vivo
III Dyneins in Ciliary Biology
Chapter 7 Composition and Assembly of Axonemal Dyneins
Chapter 8 Organization of Dyneins in the Axoneme
Chapter 9 Genetic Approaches to Axonemal Dynein Function in Chlamydomonas and Other Organisms
Chapter 10 Regulation of Axonemal Outer-Arm Dyneins in Cilia
Chapter 11 Control of Axonemal Inner Dynein Arms
Chapter 12 Flagellar Motility and the Dynein Regulatory Complex
Chapter 13 Regulation of Dynein in Ciliary and Flagellar Movement
Chapter 14 Dynein and Intraflagella Transport
IV Cytoplasmic Dynein Biology
Chapter 15 Cytoplasmic Dynein Function Define by Subunit Composition
Chapter 16 Studies of Lissencephaly and Neurodegenerative Disease Reveal Novel Aspects of
Chapter 17 Insights into Cytoplasmic Dynein Function and Regulation from Fungal Genetics
Chapter 18 Genetic Insights in to Mammalian Cytoplasmic Dynein Function Provided by Novel Mutations in Mouse
Chapter 19 Role of Dynactin in Dynein-mediated Motility
Chapter 20 Roles of Cytoplasmic Dynein during Mitosis
V Dynein Dysfunction and Disease
Chapter 21 Does Dynein Influence the Non -Mendelian Inheritance of Chromosome 17 Homologs in Male Mice?
Chapter 22 Role of Dynein in Viral Pathogenesis
Chapter 23 Cytoplasmic Dynein Dysfunction and Neurodegenerative Disease
Chapter 24 Dynein Dysfunction as a Cause of Primary Ciliary Dyskinesia and Other Ciliopathies
