Modified Nucleosides. in Biochemistry, Biotechnology and Medicine

  • ID: 2179767
  • Book
  • 684 Pages
  • John Wiley and Sons Ltd
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Nucleosides are the building blocks for life, they are found in everything

from DNA to RNA. This one–step reference is the first comprehensive

resource to integrate recent advances within this field. By

addressing the topic from different angles it has something for every

nucleoside researcher.

From the contents:

∗ Biochemistry and Biophysics

∗ Biotechnology

∗ Medicinal Chemistry

∗ Antitumorals and Antivirals

Edited by one of the main driving forces behind the field´s momentous

rise, this reference book is essential reading for a variety of scientists

involved with molecular life sciences.

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BIOCHEMISTRY AND BIOPHYSICS

Investigations on Fluorine–labeled Ribonucleic Acids by 19F–NMR Spectroscopy

8–Oxo–7,8–dihydro–2′–deoxyguanosine, a major DNA oxidation product

Modified DNA Bases: Probing Base Pair Recognition by Polymerases

2′–Deoxyribose Modified Nucleoside Triphosphates and their Recognition by DNA Polymerases

Pyrimidine Dimers: UV–induced DNA Damage

Locked Nucleic Acids: Properties, Applications and Perspectives

Studies on the synthesis and properties of oligonucleotides incorporating modified nucleobases capable for the formation of Watson and Crick type base pairs

The Properties of 4′–Thionucleosides

S–Adenosyl–L–methionine and related compounds

BIOTECHNOLOGY

5–Subsituted nucleosides in biochemistry and biotechnology

Universal base analogues and their applications to biotechnology

MEDICINAL CHEMISTRY

The Properties of Locked Methanocarba Nucleosides in Biochemistry, Biotechnology and Medicinal Chemistry

Synthesis, chemical properties and biological activities of cyclic bis(3′–5′)diguanylic acid (c–di–GMP) and its analogues

Siderophore Biosynthesis Inhibitors

Synthesis and Biological Activity of Selected Carbocyclic Nucleosides

4′–C–Ethynyl–2′–deoxynucleosides

Modified nucleosides as Selective Modulators of Adenosine Receptors for Therapeutic Use

The Design of Forodesine HCl and Other Purine Nucleoside Phosphorylase Inhibitors

Formycin and Analogues: Purine Nucleoside Phosphorylase Inhibitors and their Potential Application in Immunosuppression and cancer

1–(3–C–Ethynyl–beta–D–ribo–pentofuranosyl)cytosine (ECyd)

Syntheses and Biological Activity of Neplanocin and Analogues

Clitocine and Its Analogs

ANTITUMORALS AND ANTIVIRALS

Capecitabine Preclinical Studies: From Discovery to Translational Research

Tenofovir and Adefovir as Antiviral Agents

Clofarabine: Design to Approval

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"The overall quality of the book is high and it will be an important resource to the modified nucleoside community. The book contains a number of excellent individual chapters that offer a new and interesting perspective on the field I believe that this book will be an excellent resource for synthesis chemists looking for summaries of existing strategies to generate a wide range of modified nucleosides. Along that line, the more clinically based chapters provide good summaries of the biological activities of the modified nucleotides. There is a nice balance of older and newer literature that should be of use to established as well as novice researchers, and most of the chapters are well referenced and up–to–date. I would certainly recommend this book to anyone interested in the bioorganic and medicinal chemistry of modified nucleosides and nucleic acids." (Journal of the American Chemical Society, March 25, 2009)

"Herdewijn, with the help of the contributing authors, has assembled a fine collection of well–written and well–edited reviews. This book will be indispensable to students and researchers." (ChemBioChem, January 2009)

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