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Soft Tissue Tumors. A Multidisciplinary, Decisional Diagnostic Approach

  • ID: 2182331
  • Book
  • 448 Pages
  • John Wiley and Sons Ltd
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The first truly multidisciplinary, practical reference for decision–making in soft tissue tumor diagnosis and treatment

Soft tissue tumors (STTs) are frequently misdiagnosed in inexperienced hands. Having diagnosed and treated hundreds of patients with these difficult tumors in the last few years, Institut Curie physicians have collected core data that have contributed to breakthrough research in the morphological, biological, and molecular aspects of soft tissue tumors, resulting in valuable translational and clinical applications to patient treatment. Soft Tissue Tumors: A Multidisciplinary, Decisional Diagnostic Approach presents a distillation of these experiences combined with valuable data and perspectives contributed by senior pathologists, oncologists, and radiologists from several other of the world′s leading cancer centers of excellence.

Using state–of–the–art laboratory and clinical techniques, this balanced guide carefully considers and combines clinical pathologic (including molecular, cytogenetic, cytological, and histopathologic), radiologic, and medical and surgical oncologic data. Purposely designed to optimize the STT patient′s specific disease diagnosis and management, it provides carefully developed insights into the decision–making process and diagnostic and treatment support for a comprehensive array of STTs. Coverage includes:

  • Fully developed cytological and cytopathologic differential diagnosis, with careful consideration of both "large–sample" and "small–sample" diagnostic techniques

  • Practical tumor classification and staging, carefully calibrated and harmonized with therapeutic and natural history implications

  • Ancillary techniques that involve immunocytochemistry, Immunohistochemistry, genetic techniques, grading of STTs, and future investigation

  • Principal aspects in fine needle aspirates and core needle biopsies

Soft Tissue Tumors is the sole reference to offer physicians authoritative guidance in accurate, multidisciplinary investigation and diagnosis in order to make fully informed decisions about the correct course of STT treatment. Clinical and anatomic pathologists, cytopathologists, surgical pathologists, oncologic surgeons, radiologists, and radiation oncologists will rely on this text, as will residents in all pathology, oncology, and radiology subspecialties, cancer epidemiologists, and medical students.

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Foreword (Alain Verhest).




1 Clinical approach in soft tissue tumors (Francois Goldwasser).

1.1 Epidemiology.

1.2 Clinics and clinical profiles.

1.3 Clinical differential diagnosis.

1.4 The importance of molecular diagnosis and its perspectives.

1.5 Treatment strategies.

2 Radiological diagnostic approach in soft tissue tumors (Hervé Brisse).

2.1 Introduction.

2.2 Patient management.

2.3 Imaging techniques.

2.4 Radiologic characterization.

2.5 Tumor biopsy.

3 Sampling procedure, fine needle aspiration (FNA), and core needle biopsy (CNB) (Henryk A. Doma ski).

3.1 Advantages and limitations of FNA and CNB in soft tissue lesions.

3.2 Techniques of FNA and CNB as applied to soft tissue lesions.

3.3 Processing the FNA and CNB samples and preparation of the FNA specimen for ancillary techniques.

3.4 Challenges in the FNA and CNB of soft tissue.

3.5 Complications of FNA and CNB of soft tissue.

4 Ancillary techniques.

4.1 Immunocytochemistry (Carlos Bedrossian).

4.2 Immunohistochemistry (Réal Lagacé).

4.3 Genetic Techniques (Jérôme Couturier).

4.4 Grading of soft tissue tumors (Réal Lagacé).

4.5 Future investigations of ancillary techniques (Stamatios Theocharis).

5 Principal aspects in fine needle aspiration and core needle biopsies (Jerzy Klijanienko and Réal Lagacé).

5.1 Normal tissue.

5.2 Cytologic classification of soft tissue tumors based on the principal patterns.

5.3 Diagnostic accuracy of FNA in soft tissue tumors.

5.4 Smear composition and the differential diagnosis of soft tissue tumors.

6 Particular aspects (Jerzy Klijanienko and Réal Lagacé).

6.1 Low–grade spindle cell tumors.

6.1.1 Fibromatoses and Desmoids.

6.1.2 Nodular Fasciitis.

6.1.3 Dermatofibrosarcoma Protuberans.

6.1.4 Benign Fibrous Histiocytoma (Cellular and Atypical Variants).

6.1.5 Solitary Fibrous Tumor.

6.2 Tumors with fibrillary stroma.

6.2.1 Benign Peripheral Nerve Sheath Tumors (Schwannoma, Ancient Schwannoma and Neurofibroma).

6.2.2 Low–Grade Malignant Peripheral Nerve Sheath Tumor.

6.3 Malignant spindle cell tumors.

6.3.1 Leiomyosarcoma.

6.3.2 Synovial Sarcoma.

6.3.3 Fibrosarcoma.

6.3.4 Malignant Fibrous Histiocytoma Storiform Pattern.

6.3.5 Malignant Peripheral Nerve Sheath Tumor.

6.3.6 Spindle Cell Angiosarcoma.

6.3.7 Kaposi Sarcoma.

6.4 Myxoid tumors.

6.4.1 Myxoid Liposarcoma (With or Without Round or Spindle Cells).

6.4.2 Myxofibrosarcoma.

6.4.3 Myxoid Leiomyosarcoma.

6.4.4 Myxoma and Cellular Myxoma.

6.4.5 Chordoma.

6.4.6 Extraskeletal Myxoid Chondrosarcoma.

6.5 Atypical lipomatous tumors.

6.5.1 Well–Differentiated liposarcoma / Atypical Lipoma.

6.5.2 Spindle Cell and Pleomorphic Lipoma.

6.6 Epithelioid tumors.

6.6.1 Epithelioid Sarcoma.

6.6.2 Gastrointestinal Stromal Tumor (GIST)/Epithelioid Leiomyosarcoma.

6.6.3 Epithelioid Angiosarcoma.

6.6.4 Granular Cell Tumor.

6.6.5 Rhabdoid Tumor.

6.6.6 Alveolar Soft Part Sarcoma.

6.6.7 Clear Cell Sarcoma.

6.6.8 Malignant Melanoma and Metastases.

6.7 Pleomorphic sarcomas.

6.7.1 Pleomorphic Malignant Fibrous Histiocytoma.

6.7.2 Pleomorphic Liposarcoma.

6.7.3 Pleomorphic Leiomyosarcoma and Rhabdomyosarcoma.

6.7.4 Extraskeletal Osteosarcoma.

6.7.5 Pleomorphic Malignant Peripheral Nerve Sheath Tumor.

6.8 Round cell sarcomas.

6.8.1 Embryonnal and Alveolar Rhabdomyosarcoma.

6.8.2 Ewing Sarcoma/Peripheral Neuroectodermal Tumor.

6.8.3 Desmoplastic Small Round Cell Tumor.

6.8.4 Extraskeletal Mesenchymal Chondrosarcoma.

6.8.5 Poorly Differentiated Synovial Sarcoma.


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Jerzy Klijanienko
Real Lagace
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