The definitive benchmark for gastrointestinal dealmaking
Gastrointestinal partnering spans a broad range of indications, modalities, and stages of development, with deal structures reflecting the diversity of disease areas and therapeutic approaches across the space.This report provides a comprehensive and structured analysis of 432 gastrointestinal collaboration and licensing deals, delivering a clear and evidence-based view of how partnerships are designed, negotiated, and executed across the market.
Establish a clear view of market standards
The report enables a precise understanding of how gastrointestinal deals are structured in practice, allowing you to:
- Benchmark comparable transactions with confidence
- Detailed analysis of upfronts, milestones, and royalty structures across relevant deals
- Define realistic market parameters
- Clear insight into how deal terms vary by stage, asset type, and partner profile
- Support valuation and structuring decisions with evidence
- Ground internal discussions in real transaction data rather than assumptions
- Understand how leading companies approach dealmaking
- Visibility into partner behaviour and recurring deal structures across a diverse and evolving therapeutic landscape
- Full visibility into deal structure and execution
This includes:
- Rights granted and retained
- Development and commercialization responsibilities
- Financial structures and payment triggers
- Key contractual provisions and protections
Designed for real-world BD and strategy use
The report is widely used to:
- Structure and benchmark live transactions
- Prepare for negotiations with well-defined market context
- Evaluate partnership opportunities and counterparties
- Support internal strategy with robust, defensible data
What’s included?
- 432 gastrointestinal collaboration and licensing deals
- Financial terms, including upfronts, milestones, and royalties where disclosed
- Fully searchable deal directory (by company, therapy, and technology)
- Direct access to SEC-filed agreements and source documents
- Analysis of deal trends, key transactions, and active dealmakers
- A trusted, evidence-based reference for gastrointestinal dealmaking
Table of Contents
Executive SummaryChapter 1 - Introduction
Chapter 2 - Trends in gastrointestinal dealmaking
Chapter 3 - Financial deal terms for gastrointestinal partnering
Chapter 4 - Leading gastrointestinal deals and dealmakers
Chapter 5 - Gastrointestinal contract document directory
Chapter 6 - Gastrointestinal dealmaking by therapeutic target
Deal directory
List of Figures
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- 4D Pharma
- 4SC
- 9 Meters Biopharma
- Aayam Therapeutics
- Abbvie
- Ab E Discovery
- Aclipse Therapeutics
- AdaptivEndo
- AdaptVac
- Adiso Therapeutics
- ADL Bionatur Solutions
- Advanced Biological Laboratories
- Aerpio Pharmaceuticals
- Aevi Genomic Medicine
- AgomAb Therapeutics
- AIG Hospitals
- AI Medical Service
- Akebia Therapeutics
- Alba Therapeutics
- Alfasigma
- Alimentiv
- Alivio Therapeutics
- Allergan
- Allied Digestive Health
- Alma Bio Therapeutics
- Altos Group
- Alvit LCS Pharma
- Alvotech
- Amarex Clinical Research
- Ambry Genetics
- Ambu
- Amgen
- AnimalBiome
- Anokion
- Antibe Therapeutics
- Apogee Biotechnology
- Applied BioMath
- Arcadia Consumer Healthcare
- Ardelyx
- Arena Pharmaceuticals
- Ariel Precision Medicine
- Aristea Therapeutics
- Artizan Biosciences
- Asahi Kasei
- AscentX Medical
- Aslan Pharma
- Assembly Biosciences
- Associazione Poic e Dintorni APS
- Astellas Pharma
- AstraZeneca
- Asymchem Laboratories
- Athos Therapeutics
- Atlantic Healthcare
- Australasian Gastro Intestinal Research Foundation
- Aziyo Biologics
- AzurRx BioPharma
- Back-A-Line
- Bausch Health Companies
- Baxter International
- Bazelet
- BDD Pharma
- Beacon Discovery
- BenevolentAI
- Bharat Biotech
- BigHat Biosciences
- Bill and Melinda Gates Foundation
- BinnoPharm
- Bio-Me
- Bio-Rad Laboratories
- Bio-Thera Solutions
- BioClinica
- Biocodex Microbiota Foundation
- BioDelivery Sciences
- Biodexa Pharmaceuticals
- Biofortis
- Biogen
- Biohaven Pharmaceuticals
- Biolojic Design
- BiomeBank
- BioMed X Innovation Center
- Biomerica
- Biomica
- BiomX
- BioRap Technologies
- Biostage
- BioSurfaces
- Boehringer Ingelheim
- Boston Pharmaceuticals
- Braintree Laboratories
- Bridge Biotherapeutics
- Brigham and Women's Hospital
- Bristol-Myers Squibb
- C4X Discovery
- California Institute of Technology
- Calypso Biotech
- Camargo Pharmaceutical Services
- CannaKids
- Cannex Scientific
- Cantel Medical
- Capsulomics
- Captor Therapeutics
- Cara Care
- Carbiotix
- Case Western Reserve University
- Catholic University Leuven
- CB2 Therapeutics
- Cedars-Sinai Medical Center
- Celgene
- Celiac Disease Foundation
- Celltrion
- Celsius Therapeutics
- Censis Technologies
- Cerevance
- Cernostics
- Charles River Laboratories
- Cheplapharm Arzneimittel
- Chime Biologics
- Chinese University of Hong Kong
- Chong Kun Dang
- CHU Sainte-Justine
- Cipher Pharmaceuticals
- Cipla
- Cleveland Clinic
- Clinical Enterprise
- CN Bio
- Codexis
- Collplant
- ConvaTec
- Cook Biotech
- Cooper Pharma
- Cornell University
- Cosmo Pharmaceuticals
- COUR Pharmaceutical
- Creapharm
- CRH Medical
- Crohn's and Colitis Foundation of America
- CRS Bio
- Curant Health
- CURE Pharmaceutical
- Cyclerion Therapeutics
- Cytocom
- CytoReason
- Daewoong Pharmaceutical
- Daiichi Sankyo
- Dalriada Drug Discovery
- Danish Innovation Fund
- DayTwo
- Debiopharm
- Deciphex
- Delphi Genetics
- Department of Defense
- Dermira
- Dignify Therapeutics
- Diversigen
- DNAnexus
- Dong-A ST
- Dr. Falk Pharma
- Dr. Reddy's Laboratories
- Duke Clinical Research Institute (DCRI)
- Duke University
- EA Pharma
- Earendil Labs
- ECM Therapeutics
- Eisai
- Elanco
- Eli Lilly
- Emtora Biosciences
- EndoLogic
- enGene
- Engitix
- Ensho Therapeutics
- Entera Health
- Enterome Bioscience
- Entrinsic Health Solutions
- Equillium
- EsoCap
- Esteve
- EtectRx
- Eton Pharmaceuticals
- Eunice Kennedy Shriver Institute of Child Health and Human Development
- European Union
- Evoke Pharma
- Evolve BioSystems
- Evommune
- EVOQ Therapeutics
- Evotec
- Faes Farma
- Felix Biotechnology
- Ferring Pharmaceuticals
- Finch Therapeutics
- First Wave Bio
- Food Marble Digestive Health
- Formation Bio
- Fosun Pharmaceutical
- Foundation for Celiac Disease Outcome Measures
- French National Institute for Agricultural Research
- Fresenius Kabi Pharmaceuticals
- FSD Pharma
- Fujifilm Kyowa Kirin Biologics
- Functional Gut Diagnostics
- FutureGen Biopharm
- Future Pak
- Galapagos
- Gedeon Richter
- Genentech
- Geneoscopy
- General Automation Lab Technologies
- Genetic Analysis
- Genomic Biopharma
- Genten Therapeutics
- GentiBio
- Georgia State University
- Giiant Pharma
- Gilead Sciences
- Ginkgo BioWorks
- GI OnDEMAND
- GI Partners of Illinois
- GI Reviewers
- Gossamer Bio
- Greenstone Biosciences
- GSK
- Gusto Global
- Hadasit Bioholdings
- Haisco Pharmaceutical
- Halozyme Therapeutics
- Harvest Capital Strategies
- Helsinn Healthcare
- Helsinn Therapeutics
- Hepion Pharmaceuticals
- HiFiBio
- Highland Therapeutics
- HK inno.N
- Hollister-Stier Labs
- Holobiome
- Horizon Europe
- Hoth Therapeutics
- Hudson Institute of Medical Research
- Hyloris Pharmaceuticals
- I-mab
- Iambic Therapeutics
- Idera Pharmaceuticals
- Illumina
- IMIDomics
- Immunai
- Immune Pharmaceuticals
- Immune Therapeutics
- ImmuNext
- Immunic
- ImmunogenX
- Imperial College London
- InDex Pharmaceuticals
- Innate Pharma
- Innovate Biopharmaceuticals
- Innovate UK
- Innovation Pharmaceuticals
- Innovet
- Inotrem
- InQpharm
- Institut Gustave Roussy
- Instituto de Ciencias Farmaceuticas
- Intact Therapeutics
- Intas Pharmaceuticals
- International Centre for Diarrhoeal Disease Research
- Intract Pharma
- Intrexon
- IntroMedic
- InveniAI
- Ionis Pharmaceuticals
- Ipsen
- IQVIA
- Ironwood Pharmaceuticals
- ISOThrive
- Iterative Health
- Iterative Scopes
- Jaguar Health
- Janssen Biotech
- Janssen Pharmaceuticals
- Janssen Pharmaceutica NV
- Janssen Research & Development
- Janssen Sciences
- Jiangsu Carephar Pharmaceutical
- Jitsubo
- Johns Hopkins University
- Johnson & Johnson
- Johnson & Johnson Consumer Companies
- Johnson & Johnson Innovation
- JSR
- Juntendo University
- Juventas Therapeutics
- Kaken Pharmaceutical
- Kallyope
- Kansas University Medical Center (KUMC)
- Karolinska Institute
- Keio Gijuku University
- Kenneth Rainin Foundation (KRF)
- Kings College London
- Knight Therapeutics
- Korea Pharma
- Kwang Dong Pharmaceutical
- Kyowa Hakko Kirin
- Laboratories Acbel
- Lahey Hospital & Medical Center
- Lamassu Pharma
- Landos Biopharma
- Leona M and Harry B Helmsley Charitable Trust
- Les Laboratoires Servier
- LianBio
- LimmaTech Biologics
- LiveLeaf
- LMU University Hospital Munich
- LNC
- Lucid Diagnostics
- Luminex
- Lupin
- Lynx.MD
- Mabwell Bioscience
- Magellan Health Services
- Marinomed Biotechnologie
- Martin Pharmaceuticals
- Massachusetts General Hospital
- Massachusetts Institute of Technology
- Mayo Clinic
- McMaster University
- Medgenics
- MediBeacon
- Medical University of Graz
- Medical University of Vienna
- MedImmune
- Medtronic
- Meiji Seika
- Memorial Hermann Health System
- Memorial Sloan Kettering Cancer Center
- Merck and Co
- Mesoblast
- Metabiomics
- Metabolon
- Microba Life Sciences
- Microbiotica
- Millennium
- Mimetas
- Mission Cure
- MiTest Health
- Mitsubishi Tanabe Pharma
- Momenta Pharmaceuticals
- Monash University
- Morphic Therapeutic
- Mor Research Applications
- Moss Genomics
- Motus GI Medical Technologies
- MultiPlan
- Mundipharma
- MyBiotics Pharma
- Mylan Laboratories
- Mylan Pharmaceuticals
- Napo EU
- Napo Pharmaceuticals
- National Heart
- Lung and Blood Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institutes of Health
- National Resilience
- Nektar Therapeutics
- Neolaia Bio
- Neoteryx
- Nestle Health Science
- NeurAxis
- Neurogastrx
- New Day Diagnostics
- Newsoara Biopharma
- Nexilico
- NexOptic
- Nima
- Nipro Corporation
- Norgine
- Northeastern University
- Northwestern University
- North Zealand University Hospital
- Novartis
- Novartis Institute for Tropical Diseases
- Novome Biotechnologies
- NuBiyota
- Numab
- NuMedii
- Numerate
- Nutricion
- Nvidia
- NYU Langone Medical Center
- OMass Therapeutics
- OmniVision Technologies
- Onegevity
- One GI
- Orbis Medicines
- OSE Immunotherapeutics
- Otsuka America Pharmaceutical
- Ovation
- Owlstone Medical
- Palisade Bio
- Panaxia
- Paragon Bioservices
- Parexel
- Parexel Biotech
- Parvus Therapeutics
- Path BioAnalytics
- PAVmed
- PEAR Therapeutics
- Pendopharm
- Penn State Microbiome Center
- Pfizer
- PharmaBiome
- PharmaCare Management
- PhaseV
- Phathom Pharmaceuticals
- PlantEXT
- Pliant Therapeutics
- Portal Instruments
- PPD
- Pragma Bio
- Prana Biotechnology
- PredictImmune
- Premier Inc
- Prescient Medical
- Previse
- PRISM BioLab
- Probi
- Processa Pharmaceuticals
- Progenity
- Prometheus Biosciences
- Prometheus Laboratories
- Protagonist Therapeutics
- Proteic Bioscience
- Provention Bio
- PureTech Health
- Purnovate
- PvP Biologics
- Quadri Pharmaceuticals
- Qualicaps
- Qu Biologics
- Quell Therapeutics
- Quotient Clinical
- Quotient Therapeutics
- Rafa Pharmaceuticals
- Ramot at Tel Aviv University
- Rani Therapeutics
- Rasayana Therapeutics
- Rebiotix
- RedHill Biopharma
- Regeneron Pharmaceuticals
- Regentys
- Renexxion
- ReproCell
- Rho
- Ritter Pharmaceuticals
- Roche
- Roquette
- Royal College of Surgeons (Ireland)
- Salix Pharmaceuticals
- Samsung Bioepis
- Sandoz
- Sanofi
- Sano Genetics
- Satisfai Health
- SciCann Therapeutics
- Scipher Medicine
- Sebela Pharmaceuticals
- Second Genome
- Seed Mena
- Selexis
- Seres Therapeutics
- Serosep
- Shandong Luoxin Pharma
- Sheba Medical Center
- Shionogi
- Shire Pharmaceuticals
- Siemens Healthineers
- Signum Surgical
- Simcere Pharmaceuticals
- Simulations Plus
- Sinorda Biomedicine
- Sinovant Sciences
- Siolta Therapeutics
- SomaLogic
- SonarMD
- Sonoma BioTherapeutics
- Sosei
- Sosei Heptares
- Spaulding Clinical Research
- Stanford University School of Medicine
- Starton Therapeutics
- Statera Biopharma
- Stella Diagnostics
- Stoked Bio
- Strand Life Sciences
- Structural Genomics Consortium
- Sun Genomics
- SunRock Biopharma
- Suono Bio
- Sutter Health
- Swiss Integrative Center for Human Health
- Swixx Biopharma
- Symbiotix Biotherapies
- Synergy Pharmaceuticals
- Synlogic
- Synthetic Biologics
- Synthon
- Takeda Pharmaceutical
- Tantu Therapeutics
- TARGET PharmaSolutions
- Telcon RF Pharmaceuticals
- Tetra Bio-Pharma
- Teva Pharmaceutical Industries
- Teva Pharmaceuticals USA
- Texas A&M Health Science Center
- The Crohn's and Colitis Foundation of Canada
- Theradiag
- Theravance
- Theravance Biopharma
- Theriva Biologics
- The Vancouver Island Health Authority
- Thorne Research
- TiGenix
- Tissium
- Tivic Health Systems
- Tiziana Life Sciences
- TScan Therapeutics
- Twist Bioscience
- Ubie
- Unilever
- UniQuest
- United Digestive
- Universite catholique de Louvain
- University Gastroenterology
- University Hospital of Leuven
- University of Adelaide
- University of Augsburg
- University of Birmingham
- University of British Columbia
- University of Calgary
- University of California
- San Diego
- University of California Los Angeles
- University of California San Francisco
- University of Manitoba
- University of Massachusetts
- University of Michigan
- University of North Carolina
- University of Oslo
- University of Oxford
- University of Pennsylvania
- University of Pittsburgh
- University of Sherbrooke
- University of Tokyo
- University of Washington
- University of Windsor
- Upadia
- US Government
- Utrecht University
- Valbiotis
- Valneva
- Vcell Healthcare
- V ClinBio
- VectivBio
- Vedanta Biosciences
- Verily
- Vertex Pharmaceuticals
- Viatris
- VIPUN Medical
- Virginia Catalyst
- Virgo Surgical Video Solutions
- Virios Therapeutics
- Vital Food Processors
- Vital Therapies
- Vivante Health
- Vivelix Pharmaceuticals
- Vivtex
- Vizient
- Washington University in St Louis
- WuXi Biologics
- Yale University
- Zealand Pharma
- Zedira
- Zentiva
- Zydus Lifesciences
Methodology
- The publisher reports provide insight into the trends and terms of partnering deals in the global life sciences sector.
- The publisher reports are updated every six months to ensure the user has access to the latest announcements and trends in the topic focus of the report.
- The publisher analysts review the deal data to provide an overview and analysis of deal trends, including example deals and terms.
- The publisher reports source deal data from our proprietary deals and alliances database. The database is updated daily by our analysts with new deals as they are announced globally by the company’s party to the deal.
- The data in the deals and alliances database is obtained from secondary sources such as publicly available industry sources including press releases, company presentations, investor presentations, company SEC filings, other company filings, company websites, conference presentations. Sources are identified to allow for user verification.
The publisher provides comprehensive coverage of the following partnering or deal types:
- Asset purchase
- Assignment
- Co-development
- Co-market
- Co-promotion
- Collaborative R&D
- Contract service
- CRADA
- Cross-licensing
- Development
- Distribution
- Equity purchase
- Evaluation
- Grant
- Joint venture
- Licensing
- Loan
- Manufacturing
- Marketing
- Option
- Promotion
- Research
- Royalty financing
- Settlement
- Spin out
- Sub license
- Supply
- Termination
- Warrant
Every deal record is fully categorized and includes the following data, where available:
- Industry sector
- Therapy areas
- Technology type
- Deal components
- Financial terms
- Stage of development
- Exclusivity
- Asset type
- Geographic focus
- Excluded geography
- Company press release
- SEC filing data including contract document
All financial amounts are converted to US$ using the exchange rate available on the date of deal announcement, enabling direct comparison of deal terms across international territories.
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