Autophagy in Health and Disease. Edition No. 2

Table of Contents

A. Overview 1. Introduction 2. Mechanisms of autophagy the machinery of macroautophagy and points of control 3. Regulation of autophagy- transcriptional, post-transcriptional, translational and post-translational 4. Selectivity and trafficking of autophagic cargos 5. Role of Lysosomes in autophagy 6. Methods for studying autophagy 7. Effects of Physiologic Inputs on Autophagy (with considerations of the impact of gender, fasting/feeding, circadian rhythms, exercise and aging)

B. Development 8. Stem cells and iPSCs 9. Embryogenesis 10. Hematopoiesis 11. Paligenosis

C. Metabolic control and diabetes 12. Liver 13. Adipose 14. Pancreas 15. Skeletal muscle

D. Cardiovascular system 16. Heart 17. Lungs 18. Vasculature

E. The nervous system and neurodegeneration 19. Autophagy in neurons and the CNS: function and homeostasis 20. Altered mitophagy on the path to Parkinsons disease 21. Autophagic processes in early- and late- onset Alzheimer's disease 22. Autophagic involvement in other neurodegenerative disorders

F. Homeostasis and disease in other organ systems 23. Autophagy as an integral component of the immune system (including infection and sepsis) 24. Autophagy in the gastrointestinal system and cross-talk with microbiota 25. Autophagy in building and maintaining the skeletal system

G. Additional disease considerations 26. Autophagy on the road to longevity and aging 27. Autophagy in cancer, friend or foe? 28. Micro autophagy mechanisms and disease 29. Chaperone mediated autophagy mechanisms and disease 30. Therapeutic targeting of Autophagy, lifestyle and pharmacology

Authors

Rothermel, Beverly Bev Rothermel, PhD, is an Associate Professor at the University of Texas Southwestern Medical Center in Dallas, TX, with appointments in the Departments of Internal Medicine (Cardiology) and Molecular Biology. Her laboratory was directly involved in some of the first studies demonstrating the dual nature of autophagy in the cardiovascular system. She has lectured on the role of autophagy in human disease for more than ten years as a component of the graduate school's Integrative Biology program. Current studies in her lab seek to understand circadian regulation of cardiac mitophagy as well as identify the causes and consequences of suppressed autophagy in Down syndrome. Her research is supported by the National Institutes of Health's INCLUDE Project, the Wellstone Muscular Dystrophy Research Network, and the American Heart Association. Diwan, Abhinav Abhinav Diwan, MBBS, is a physician-scientist and a board-certified cardiologist, and directs a laboratory-based research program focused on basic and translational studies to therapeutically target the autophagy-lysosome pathway in human disease. He is Professor of Medicine, Cell Biology and Physiology, and Obstetrics and Gynecology at Washington University in Saint Louis, Missouri, USA and Staff Physician at the John Cochran Veterans Affairs Medical Center in Saint Louis. Studies from his laboratory have uncovered evidence for acquired lysosome dysfunction as a common cellular in cardiomyopathy and heart failure, Alzheimer's disease and diabetes. Translational research from his program has established the autophagy-lysosome pathway as a viable therapeutic target, with activation of the lysosome biogenesis program as an exciting strategy in these conditions. He has also proven to be an outstanding mentor to the next generation of physician-scientists, an effort he leads as the program director of the Investigator Training Pathway in the Cardiovascular Division supported by a NIH T32 training grant.