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The interdisciplinary nature of the contributions reflects the fact that the subject is a multifaceted field of research integrating the traditionally separate subjects of biological and behavioral science. Psychoneuroimmunology attains a realistic appreciation of the interplay between different biological systems as they collectively maintain health and combat environmental challenges to health. Background material is balanced by a detailed assessment of emerging topics in psychoneuroimmunological research that focuses on the clinical and practical implications of findings from empirical studies on both humans and animals. While specialist readers will appreciate the coverage of progress made in psychoneuroimmunology, newcomers will gain much from its informed and accessible introduction to the field, as well as its exploration of a variety of methodological approaches.
Preface ixAlexander W. Kusnecov and Hymie Anisman
Foreword xiiiRobert Ader and Nicholas Cohen
List of Contributors xvii
1 Basic Principles in Immunology: Relevance for Studies in Psychoneuroimmunology 1Sarah M. Clark, Kerry C. Michael, Achsah D. Keegan, and Leonardo H. Tonelli
2 Innervation of the Immune System 24Denise L. Bellinger, Dwight M. Nance, and Dianne Lorton
3 In Vitro and In Vivo Assessment of Immune System Modulation of Brain Function and Neurochemistry 73Michael O. Poulter and Zul Merali
4 Control and Contributions of the Blood Brain Barriers to Cytokine Levels in the CNS 88William A. Banks
5 The Immune Neuroendocrine Network in Health and Disease 99Adriana del Rey and Hugo O. Besedovsky
6 Neural Functions of Hematopoietic–derived Cells 120Noel C. Derecki and Jonathan Kipnis
7 Immunoregulatory Neuropeptides 144Doina Ganea and Mario Skarica
8 Regulation of Immune Cell Activity by Norepinephrine and Beta2–Adrenergic Receptor Engagement 161Caroline J. Padro, Jaclyn W. McAlees, and Virginia M. Sanders
9 Immune–to–Brain Communication in Pain: Historical Perspectives, New Directions 176Peter M. Grace, Linda R. Watkins, and Mark R. Hutchinson
10 Stress and Neuroendocrine Immune Interaction: A Therapeutic Role for Beta–endorphin 198Olivia Wynne and Dipak K. Sarkar
11 Assessing Neuroendocrine–Mediated Modulation of Immunity to Infection in Animals: Caveats and Methodological Issues 212Jodi L. Yorty and Robert H. Bonneau
12 Approaches to Assessing Stressor–Induced Cytokine and Endocrine Changes in Humans 234Kim Matheson and Hymie Anisman
13 Stress and Immune Function in Humans: A Life–Course Perspective 251Jan A. Moynihan, Kathi L. Heffner, Mary T. Caserta, and Thomas G. O′Connor
14 Predicting Health: The Role of the Early–Life Environment 266Luba Sominsky, Adam K. Walker, and Deborah M. Hodgson
15 Microglia and Neurodevelopment: Programming of Cognition throughout the Lifespan 296Jaclyn M. Schwarz and Staci D. Bilbo
16 Aging and the Immune System 313Ashley M. Fenn, Angela W. Corona, and Jonathan P. Godbout
17 Peripheral Pro–inflammatory Cytokines and Cognitive Aging: The Role of Metabolic Risk 330Alvin Lim and Anna Marsland
18 Immune Stimulation and Cognitive Function: Defining the Deficits and Avoiding the Pitfalls 347Colm Cunningham
19 The Role of NF–kB in Behavioral and Neural Plasticity 365Elyse M. Mallimo and Alexander W. Kusnecov
20 Inflammatory Roads to Neurodegeneration: A Focus on Parkinson′s and Alzheimer′s Disease 393Shawn Hayley and Darcy Litteljohn
21 The Psychotic Face of the Immune System: Inflammation and Schizophrenia 411Urs Meyer
22 Neuroimmune Mechanisms in Autism 425Veronica M. Miller, Rachael Racine, and Steven S. Zalcman
23 Depression, Inflammation and Tryptophan Metabolism 448Robert H. McCusker, Annemieke Kavelaars, Cobi J. Heijnen, Robert Dantzer, and Keith W. Kelley
24 An Inflammatory Perspective of Stress and Human Depressive Disorder 469M.–C. Audet, S. Jacobson–Pick, R. McQuaid, and Hymie Anisman
25 Interaction Between Immune and Energy–Balance Signals in the Regulation of Feeding and Metabolism 488Alfonso Abizaid, Giamal Luheshi, and Barbara C. Woodside
26 Psychoneuroimmunological Processes in Coronary Artery Disease and Heart Failure 504Willem J. Kop and Paula M.C. Mommersteeg
Index 525
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Hymie Anisman is a full Professor in the department of Neuroscience, Carleton University, Canada. He holds the distinguished Canada Research Chair in Neuroscience. The principle theme of his research has been the influence of stressors on neurochemical, neuroendocrine and immune systems, and how these influence psychiatric disorders, including depression, anxiety and PTSD.
