Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable.
- Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes
- Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials
- Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy
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1. Introduction to Epigenetics 2. Laboratory Methods in Epigenetics 3. Keratinocyte Differentiation and Epigenetics 4. Fibroblast Differentiation and Epigenetics 5. Epigenetic Modulation on Hair Follicle Stem Cells 6. Epigenetics and the Regulation of Inflammation 7. Malignant Transformation and Epigenetics 8. Sirtuins and Epigenetics and Dermatology 9. MicroRNAs in Skin Diseases 10. Systemic Lupus Erythematosus 11. Psoriasis 12. Scleroderma 13. Allergic and Inflammatory Skin Diseases 14. Other Autoimmune Diseases 15. Infectious Skin Diseases 16. Melanoma 17. Cutaneous T-cell Lymphoma 18. Aging 19. Diagnostic Techniques Employing Epigenetics 20. Therapeutic Approaches using Epigenetics 21. The Changing World and Epigenetics
How the Environment Influences Epigenetics
Chang, Christopher C.
Dr Chang is the current Medical Director for Pediatric Immunology, Allergy and Rheumatology at Joe DiMaggio Children's Hospital in Florida. At the same time, he serves as Associate Program Director for the Allergy Immunology Fellowship program at the University of California at Davis. Dr. Chang has previously been Chief of the Division of Allergy and Immunology at Thomas Jefferson University and Nemours Children's Hospital in Philadelphia, PA and Wilmington, DE, respectively. He is a fellow of the American Academy of Allergy, Asthma and Immunology (AAAAI) and the American College of Allergy, Asthma and Immunology (ACAAI), and a member of the Clinical Immunology Society (CIS) and the American Association of Immunologists (AAI). He is Chair of the Core Curriculum, Education and Residency Review Committee of the AAAAI and Vice-chair of the Training Program Directors Committee of the ACAAI. He has over 100 original publications and has authored over 20 chapters in immunology, rheumatology and allergy books, and has also edited 2 books with a third on the way. He has over 30 years' experience in the practice of Immunology and Allergy and has been involved in the education of future allergists and immunologists at the levels of the medical student, resident and fellow
Richardson, Bruce C.