Personalized Epigenetics

Table of Contents

Section I: Overview

1. Epigenetics of Personalized Medicine

Section II: Epigenetic Variations Among Individuals

2. Inter-individual Variability of DNA Methylation

3. Differences in Histone Modifications Between Individuals

4. Individual Noncoding RNA Variations: Their Role in Shaping and Maintaining the Epigenetic Landscape

5. Personalized Epigenetics: Analysis and Interpretation of DNA Methylation Variation

Section III: Bioinformatics of Personalized Epigenetics

6. Computational Methods in Epigenetics

Section IV: Diagnostic and Prognostic Epigenetic Approaches to Personalized Medicine

7. Epigenetic Biomarkers in Personalized Medicine

8. Epigenetic 'Fingerprint'

9. Epigenetics of Personalized Toxicology

Section V: Environmental Personalized Epigenetics

10. Environmental Contaminants and their Impacts on the Epigenome

11. Nutriepigenomics: Personalized Nutrition Meets Epigenetics

Section VI. Pharmacology and Drug Development of Personalized Epigenetics

12. Personalized Pharmacoepigenomics

13. Personalized Medicine and Epigenetic Drug Development

Section VII: Personalized Epigenetics of Disorders and Disease Management

14. Epigenetics and Personalized Pain Management

15. Understanding Inter-individual Epigenetic Variations in Obesity and its Management

16. Epigenetic Modification of miRNAs in Cancer

17. Managing Autoimmune Disorders Through Personalized Epigenetic Approaches

18. Cardiovascular Diseases and Personalized Epigenetics

Section VIII: Challenges and Future Directions

19. Future Challenges and Prospects for Personalized Epigenetics

Authors

Trygve O. Tollefsbol Professor of Biology and Senior Scientist, Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center; Comprehensive Diabetes Center, University of Alabama at Birmingham (UAB), USA. Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor's degree in Biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.