The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues.
The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment.
Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples.
- Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies- Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring- Chapters are replete with clinical examples to empower the basic biology with translational significance- Offers more than 100 illustrations to distill key concepts and decipher complex science
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Preface Gary Felsenfeld
1. Introduction and History Suming Huang
2. Histone Modifications Michael Litt
3. Genomic imprinting in mammals
memories of generations past Nora Engel
4. Polycomb and trithorax factors in transcriptional and epigenetic regulation Priscilla Nga Ieng Lau and Chi Wai Eric So
5. Chromatin dynamics and genome organization in development and disease Changwang Deng, Bhavita Patel, Yangqiu Li and Suming Huang
6. ncRNA function in chromatin organization Keith E. Giles, Jessica L. Woolnough and Blake Atwood
7. Epigenetic Gene Regulation and Stem Cell Function Aissa Benyoucef and Marjorie Brand
8. Epigenetic Inheritance Benjamin B. Mills, Christine M. McBride and Nicole C. Riddle
9. Transgenerational epigenetic regulation by environmental factors in human diseases Yuanyuan Li
10. Identification of intergenic long non-coding RNA by deep sequencing Gangqing Hu and Keji Zhao
11. Regulation of erythroid cell differentiation by transcription factors, chromatin structure alterations, and noncoding RNA Alex Xiucheng Fan, Mir A. Hossain, Jared Stees, Ekaterina Gavrilova and Jörg Bungert
12. Genetically altered cancer epigenome Ming Tang, Huacheng Luo and Jianrong Lu
13. Long non-coding RNAs and carcinogenesis Félix Recillas-Targa
14. Epigenetics of physiological and premature aging Shrestha Ghosh and Zhongjun Zhou
15. Epigenetic Effects of Environment and Diet Jason O. Brant and Thomas P. Yang
16. Epigenetic control of stress-induced apoptosis Lei Zhou
17. Structure, Regulation, and Function of TET Family Proteins Xin Hu, Yun Chen and Zhizhuang Joe Zhao
18. Epigenetic drugs for cancer therapy Bowen Yan, Xuehui Li, Yurong Yang, Wei Jian and Yi Qiu
19. Epigenetic Mechanisms as Key Regulators in Disease. Clinical Implications and Case Studies Abdelhalim Boukaba, Fabian Sanchis-Gomar, José Luis García-Giménez