Transporters in Drug Discovery and Development. Detailed Concepts and Best Practice. Woodhead Publishing Series in Biomedicine


Book
October 2018
Elsevier Science and Technology
ID: 3744613

Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments.

Membrane transporters and the diseases corresponding to functional defects; P-glycoprotein (P-gp/MDR1)/ABCB1; Multidrug resistance- associated protein 2 (MRP2/ABCC2); Breast cancer resistance protein (BCRP)/ABCG2; The bile salt export pump (BSEP/ABCB11); Organic anion- transporting polypeptides (OATPs/SLCOs); Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs); Drug transporters in drug discovery and development; Transporter study methodologies.

Authors

Yurong Lai A major US pharmaceutical company, USA. Yurong Lai is a senior principal scientist at a US-based pharmaceutical company. He received his M.D. from Fujian Medical University in China and a Ph.D. (Toxicology) from Sapporo Medical University in Japan. From 1998 to 2001, he was a research fellow of Japanese Society for Promotion (JSPS) in Department of Physiopathology, Graduate School of Medicine of Hokkaido University, followed by a position as Research Associate in Department of Pharmaceutics, University of Washington

Table of Contents

Authors

Related Topics

Related Products

Emerging Medical Technologies Spotlight

Rubidium Market Report by Production Process (Lepidolite, Pollucite, and Others), Grade (Technical Grade Metal, High-purity Grade), Application Sector (Biomedical Research, Electronics, Specialty Glass, Pyrotechnics, and Others), and Region 2024-2032

Drug Transporters. Molecular Characterization and Role in Drug Disposition. Edition No. 3. Wiley Series in Drug Discovery and Development

Exchangers. Current Topics in Membranes Volume 73

Computational Toxicology. Risk Assessment for Chemicals. Edition No. 1. Wiley Series on Technologies for the Pharmaceutical Industry