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Transporters in Drug Discovery and Development

  • ID: 3744613
  • Book
  • 780 Pages
  • Elsevier Science and Technology
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Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments.

- A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development
- Balanced coverage of molecular biology aspects and functional outcomes
- State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity
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Membrane transporters and the diseases corresponding to functional defects
P-glycoprotein (P-gp/MDR1)/ABCB1
Multidrug resistance- associated protein 2 (MRP2/ABCC2)
Breast cancer resistance protein (BCRP)/ABCG2
The bile salt export pump (BSEP/ABCB11)
Organic anion- transporting polypeptides (OATPs/SLCOs)
Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs)
Drug transporters in drug discovery and development
Transporter study methodologies.
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Lai, Yurong
Yurong Lai is a senior principal scientist at a US-based pharmaceutical company. He received his M.D. from Fujian Medical University in China and a Ph.D. (Toxicology) from Sapporo Medical University in Japan. From 1998 to 2001, he was a research fellow of Japanese Society for Promotion (JSPS) in Department of Physiopathology, Graduate School of Medicine of Hokkaido University, followed by a position as Research Associate in Department of Pharmaceutics, University of Washington
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