Neuroepidemiology covers the foundations of neuroepidemiological research and the epidemiology of disorders primarily affecting the nervous system, as well as those originating outside the nervous system. The etiology of many important central nervous system disorders remains elusive. Even with diseases where the key risk determinants have been identified, better prevention and therapy is needed to reduce high incidence and mortality. Although evolving technologies for studying disease provide opportunities for such, it is essential for researchers and clinicians to understand how best to apply such technology in the context of carefully characterized patient populations.
By paying special attention to methodological approaches, this volume prepares new investigators from a variety of disciplines to conduct epidemiological studies in order to discern the etiologic factors and underlying mechanisms that influence the onset, progression, and recurrence of CNS disorders and diseases. The book also provides current information on methodological approaches for clinical neurologists seeking to expand their knowledge in research.
- Includes coverage of the foundations of neuroepidemiological research and the epidemiology of disorders primarily affecting the nervous system, as well as those originating outside the nervous system
- Describes the most recent methodologies to define and quantify the burden of CNS disorders and to understand the underlying mechanisms, with neuroimaging and molecular methods receiving particular emphasis
- Offers extensive description of those neurological conditions that are secondary to other diseases whose incidence is on the rise because of longer survival rates
- Features chapters authored by leaders in the field from around the globe
SECTION 1 Principles and foundations of epidemiology and neurology research
1. Epidemiology for the clinical neurologist
2. Population neuroscience
3. Advanced epidemiological analytical methods
4. Basics of neuroanatomy and neurophysiology C.K. Barha, L.S. Nagamatsu and T. Liu-Ambrose
5. Population imaging in neuroepidemiology
6. Use of "omics technologies to dissect neurological disease
7. Neuropsychological assessment
SECTION 2 Epidemiology of disorders primarily affecting the nervous system
9. Epidemiology of alphasynucleinopathies from Parkinson disease to dementia with Lewy bodies
10. Epidemiology of epilepsy
11. The epidemiology of multiple sclerosis: insights to a causal cascade
12. Neuroepidemiology of traumatic brain injury
13. The epidemiology of amyotrophic lateral sclerosis
14. Cerebrovascular disease
15. Peripheral neuropathies
SECTION 3 Neurocognitive consequences of cancer and treatment-related neurocognitive dysfunction in adult-onset cancer patients and survivors
17. Neuroepidemiology of cancer and treatment-related neurocognitive dysfunction in adult-onset cancer patients and survivors
18. Sickle cell disease
Dr. Rosano is Professor of Epidemiology at the University of Pittsburgh, Pittsburgh USA. Dr. Rosano's research integrates methods from the fields of neuroimaging, geriatric medicine, epidemiology and neuroscience to implement novel strategies for improving brain health and function. Her work to date has characterized and contrasted "normal? brain aging in older adults and "accelerated? brain aging in adults exposed to chronic diseases.
Ikram, M. Arfan
Dr. Ikram is associate professor of Neuroepidemiology at the Erasmus University Medical Center in Rotterdam, the Netherlands. He is principal investigator of the Rotterdam Study and of the neurology core of the Rotterdam Study. His focus is on understanding the occurrence causes, pre-clinical phase and prognosis of neurological disease in late life, thereby focusing particularly on dementia and its subtypes, stroke, Parkinson's disease.
Mary Ganguli, MD, MPH, FRCP(C), is Professor of Psychiatry, Neurology, and Epidemiology at the University of Pittsburgh (Pittsburgh, PA, USA). She specializes in geriatric psychiatry and psychiatric epidemiology. She has for the past 30 years conducted large-scale population studies in the USA and in India, focused on the epidemiology of cognitive impairment and dementia in older adults. She has published extensively on these topics, served on editorial boards and as associate editor for several journals, on work groups of the American Psychiatric Association and the American Academy of Neurology, and as grant reviewer for the National Institutes of Health and other funding agencies.