Biotechnology of Microbial Enzymes: Production, Biocatalysis and Industrial Applications provides a complete survey of the latest innovations on microbial enzymes, highlighting biotechnological advances in their production and purification along with information on successful applications as biocatalysts in several chemical and industrial processes under mild and green conditions.
Applications of microbial enzymes in food, feed, and pharmaceutical industries are given particular emphasis. The application of recombinant DNA technology within industrial fermentation and the production of enzymes over the last 20 years have produced a host of useful chemical and biochemical substances. The power of these technologies results in novel transformations, better enzymes, a wide variety of applications, and the unprecedented development of biocatalysts through the ongoing integration of molecular biology methodology, all of which is covered insightfully and in-depth within the book.
- Features research on microbial enzymes from basic science through application in multiple industry sectors for a comprehensive approach
- Includes information on metabolic pathway engineering, metagenomic screening, microbial genomes, extremophiles, rational design, directed evolution, and more
- Provides a holistic approach to the research of microbial enzymes
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Chapter 1. Useful Microbial Enzymes-An Introduction
Chapter 2. Production, Purification, and Application of Microbial Enzymes
Chapter 3. Solid State Fermentation for Production of Microbial Cellulases
Chapter 4. Hyperthermophilic Subtilisin-Like Proteases From Thermococcus kodakarensis
Chapter 5. Enzymes from Basidiomycetes-Peculiar and Efficient Tools for Biotechnology
Chapter 6. Microbial Production and Molecular Engineering of Industrial Enzymes: Challenges and Strategies
Chapter 7. Metagenomics and the Search for Industrial Enzymes
Chapter 8. The Pocket Manual of Directed Evolution: Tips and Tricks
Chapter 9. Insights into the Structure and Molecular Mechanisms of ?-Lactam Synthesizing Enzymes in Fungi
Chapter 10. The Cellulosome: A Supramolecular Assembly of Microbial Biomass-Degrading Enzymes
Chapter 11. Microbial Enzymes of Use in Industry
Chapter 12. Significance of Microbial Glucokinases
Chapter 13. Lipase-Catalyzed Organic Transformations: A Recent Update
Chapter 14. Enzymatic Biocatalysis in Chemical Transformations: A Promising and Emerging Field in Green Chemistry Practice
Chapter 15. Microbial Enzymes for Glycoside Synthesis: Development of Sucrose Phosphorylase as a Test Case
Chapter 16. Industrial Applications of Multistep Enzyme Reactions
Chapter 17. Biocatalysis for Industrial Production of Active Pharmaceutical Ingredients (APIs)
Chapter 18. Agro-Industrial Residues and Microbial Enzymes: An Overview on the Eco-Friendly Bioconversion into High Value-Added Products
Chapter 19. Microbial Enzymes for the Food Industry
Chapter 20. Productive Chain of Biofuels and Industrial Biocatalysis: Two Important Opportunities for Brazilian Sustainable Development
Professor Dr. Goutam Brahmachari was born at Barala in the district of Murshidabad (West Bengal), India, on April 14, 1969. He received his high school degree in scientific studies in 1986 at Barala R. D. Sen High School under the West Bengal Council of Higher secondary Education (WBCHSE). Then he moved to Visva-Bharati (a central university founded by Rabindranath Tagore at Santiniketan, West Bengal, India) to study chemistry at the undergraduate level. After graduating from this university in 1990, Prof. Brahmachari completed his masters in 1992 with specialization in organic chemistry and thereafter received his PhD degree in 1997 in chemistry from the same university. He was appointed as assistant professor of organic chemistry in the Department of Chemistry, Visva-Bharati University, in 1998, and became associate professor in 2008. In 2011, he became full professor of organic chemistry in the same faculty. At present, he is responsible for teaching courses in organic chemistry, natural products chemistry, and physical methods in organic chemistry. Several students have received their PhD degree under the supervision of Prof. Brahmachari during this period, and a couple of research fellows are presently working with him both in the fields of natural products and synthetic organic chemistry. He serves as a member of the Indian Association for the Cultivation of Science (IACS) and Indian Science Congress Association (ISCA), Kolkata, and as an Editor-in-Chief, Signpost Open Access Journal of Organic and Biomolecular Chemistry. He also serves as an editorial advisory board member for several journals and is the Who's Who in the World-2015 Listee. He is a recipient of the 3rd Academic Brilliance Award-2015 (Award for Excellence in Research).
Prof. Brahmachari's research interests include (i) synthetic organic chemistry with special emphasis on green chemistry; (ii) isolation, structural determination, and/or detailed NMR study of new natural products from medicinal plants; (iii) semi-synthetic studies with natural products; and (iv) evaluation of biological activities and pharmacological potential of natural and synthetic compounds. With more than 16 years of teaching experience, he has produced so far nearly 120 scientific publications including original research papers, review articles, and invited book chapters in edited books in the field of natural products and organic synthesis from internationally reputed presses. Prof. Brahmachari has authored/edited a number of text and major reference books that include Organic Name Reactions: A Unified Approach (Narosa Publishing House, New Delhi; co-published by Alpha Science International, Oxford, 2006), Chemistry of Natural Products: Recent Trends & Developments (Research Signpost, 2006), Organic Chemistry Through Solved Problems (Narosa Publishing House, New Delhi; co-published by Alpha Science International, Oxford, 2007), Natural Products: Chemistry, Biochemistry and Pharmacology (Narosa Publishing House, New Delhi; co-published by Alpha Science International, Oxford, 2009), Handbook of Pharmaceutical Natural Products-2 volume-set (Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2010), Bioactive Natural Products: Opportunities & Challenges in Medicinal Chemistry (World Scientific Publishing Co. Pte. Ltd., Singapore, 2011), Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds (CRC Press, Taylor & Francis group, USA, 2013), Natural Bioactive Molecules: Impacts & Prospects (Narosa Publishing House, New Delhi; co-published by Alpha Science International, Oxford, 2014), Green Synthetic Approaches for Biologically Relevant Heterocycles (Elsevier Inc., USA, 2014), and Bioactive Natural Products-Chemistry & Biology (Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2015).
He is regularly consulted as a referee by leading international journals including Elsevier, Royal Society of Chemistry, American Chemical Society, Wiley, Taylor & Francis, Springer, Bentham Science, Indian Chemical Society, Pakistan Chemical Society, Korean Chemical Society, Brazilian Chemical Society, Bulgarian Academy of Sciences, and so on, and also various financial commissions.
Prof. Brahmachari enjoys Songs of Rabindranath Tagore and finds interests in Literature as well!