Looking at Ribozymes: From Atomic to Molecular and Cellular Scales introduces ideas on how ribozymes "work through a comparison of their common features and specificities. It covers how the (macro) molecular organization at different scales make it possible, what function they carry, where they are found, how they evolved, and how have they been used. The book emphasizes common and specific features of natural and artificial ribozymes, from the basics, to more advanced aspects, making it ideal for undergraduates, grad students and researchers. Specific sections cover different areas of research, from the atomic scale (catalysis), to the molecular (folding, dynamics).
In addition, other sections cover macromolecular and cellular scales (dynamics, long-range interactions, self-assembly, cellular processes). The book is not a directory of ribozymes, it instead provides comparative knowledge, including the interdependent relationships between the different scales of description based on different experimental and theoretical approaches.
- Provides a comparative knowledge of ribozymes based on scales of organization and description
- Covers different areas of research, from the atomic scale (catalysis), to the molecular (folding, dynamics), macromolecular and cellular scales
- Includes the interdependent relationships between the different scales of description based on experimental and theoretical approaches
1. RNA: from non-enzymatic to enzymatic catalysis
2. Catalytic diversity in ribozyme subclasses
3. Folding, structure and dynamics of ribozymes
4. Long-range interactions and macromolecular assemblies
5. Molecular adaptation during evolution
6. Ribozymes in Cellular Processes: from viroids to eukaryotes
7. Natural and artificial ribozymes: evolution and design
Fabrice Leclerc is a research fellow at the French National Centre for Scientific Research, Paris with expertise in Biophysics, Bioinformatics and Structural Biology
Benoît Masquida is a research fellow at the Institut de Biologie Moléculaire et Cellulaire of the CNRS and Université Louis Pasteur