Looking at Ribozymes: From Atomic to Molecular and Cellular Scales introduces ideas on how ribozymes "work through a comparison of their common features and specificities. It covers how the (macro) molecular organization at different scales make it possible, what function they carry, where they are found, how they evolved, and how have they been used. The book emphasizes common and specific features of natural and artificial ribozymes, from the basics, to more advanced aspects, making it ideal for undergraduates, grad students and researchers. Specific sections cover different areas of research, from the atomic scale (catalysis), to the molecular (folding, dynamics).
In addition, other sections cover macromolecular and cellular scales (dynamics, long-range interactions, self-assembly, cellular processes). The book is not a directory of ribozymes, it instead provides comparative knowledge, including the interdependent relationships between the different scales of description based on different experimental and theoretical approaches.
- Give key ideas about how ribozymes work
- Explain the functioning of the (macro) molecular organization at different scales
- Focus on the common and specific characteristics of natural and artificial ribozymes
- Compare interrelated relationships between different scales of description
- Provide a new way of looking at ribozymes that can be a source of inspiration
2. Catalytic diversity in ribozyme subclasses
3. Folding, structure and dynamics of ribozymes
4. Long-range interactions and macromolecular assemblies
5. Molecular adaptation during evolution
6. Ribozymes in Cellular Processes: from viroids to eukaryotes
7. Natural and artificial ribozymes: evolution and design
Fabrice Leclerc is a research fellow at the French National Centre for Scientific Research, Paris with expertise in Biophysics, Bioinformatics and Structural Biology
Benoît Masquida was born in Strasbourg in 1970. After a national competition of crystallography and biological biology, he made a visit under the direction of Professor Eric Westhof in Strasbourg, where he is fascinated by the study of the structure of nucleic acids by modeling. molecular and by crystallography. After that, he is part of Yale University in the US to continue his structural studies at Professor Jennifer Doudna.
Since 2001, he has been a researcher at the CNRS in the study of RNA structures with a marked interest for ribozymes and protein-RNA complexes in the context of various biological methods such as the inflammatory response or the role of RNA in mitochondria. He is the author of about fifty peer-reviewed journal articles and book chapters.