This is the only up–to–date handbook to cover the topic from so many different standpoints, addressing a broad readership in academia and industry. The result is a comprehensive overview of recent work on polyketide natural products. Organized into important classes of polyketides with significant therapeutic potential, each chapter provides information on the isolation, synthesis, biosynthesis, and biological studies of selected examples. An essential one–stop compendium for chemists and biologists working in the field of natural product synthesis and chemical biology.
Table of Contents
I. BASIC PATHWAYS OVERVIEW1. Type I (Macrolide Antibiotics: Erythromycin and Pikromycin)
2. Type II Polyketides (Enterocin)
3. Type III Polyketides (Resveratrol)
4. Fungal Polyketides (lovastatin)
5. Mixed NRPS–PKS (Epothilones)
6. Post PKS 1: Methyl Transferases
7. Post PKS 2: Epoxidases
8. Post PKS 3: Glycosidases (Apoptolidin)
9. Post PKS 4: Oxidoreductases (Spirangien)
II. ADVANCED TOPICS
10. Beta–branching (Curacin)
11. Trans–AT (Pederin)
12. Skipping/Iterative/Non–linearity (Aureothin /
Borrelidin)
13. Polyethers (Monensin)
14. Engineering (Doramectin)
15. Metagenomes (Bryostatin)
III. APPENDIX/GLOSSARY
