The Cellular Secretome and Organ Crosstalk focuses on the release of peptides and proteins from different organs and their specific functions in metabolic regulation and cell- and organ crosstalk. The book is written for experts in the field, however, for each topic, helpful references are included. The book also includes technical sections that summarize the state-of-the-art of secretome and crosstalk analysis. This book fulfills the need for a resource that comprehensively describes the current knowledge of secretome biology in health and disease.
Communication between different organs involves lipids and other small molecules and a host of proteins and peptides comprising the secretome of different organs (organokinome). More than 600 adipokines have been identified, and an increasing number of hepatokines and myokines have recently been discovered with mostly unknown physiological impact. Importantly, an aberrant signature of the organokinome may be critically underlying a variety of metabolic diseases and may determine the individual susceptibility to disease development.
- Summarizes our current knowledge on the secretome of different cells and tissues
- Dissects auto-, para- and endocrine functions of major secreted peptides and proteins
- Analyzes the secretory malfunction of different cells and its impact for disease development
- Authored by a leader in the field, presenting a coherent view on this very complex topic
2. Adipose tissue
a major secretory organ
3. Skeletal muscle
a novel secretory organ
an integrated view on the fat/muscle axis
an extended view on the crosstalk scenario
6. Secretory malfunction
a key step to metabolic diseases
7. Conclusion and outlook
8. Technical Annex: Secretome and crosstalk analysis
Dr. Eckel is the head of the German Diabetes Center. His laboratory has been working on the topic of cellular secretome and organ crosstalk for more than 20 years. His lab was the first to describe the crosstalk between human fat and muscle using a co-culture model. Between 2004 and 2012 Dr. Eckel was the coordinator of two large European projects on adipose tissue secretory function and organ crosstalk. More than 10 review papers on this topic have been published by his group during the last five years.