Protein Modificomics: From Modification to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins including diseases involving PTM's, plant PTM's, role of therapeutic strategies and other topics such as translational proteomics.
PTMs make the major backbone of several key biological processes. It has been known that many proteins often undergo unwanted modifications leading to the disruption of proteostasis and ultimately gain in disease etiology. These diseases include Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome, OFC10 etc. Cancer is also one of the major complex diseases wherein various proteins undergo undesired modifications that result in deregulation of the cell cycle, disruption of DNA repair mechanisms and also the inactivation of the proapoptotic pathways etc. Furthermore, the allosteric insight to regulation or deregulation of the protein structure due to modifications is of immense importance for designing drugs for therapeutic intervention of diseases caused due to the modifications.
PTMs also play a very important role in plant physiology and production of medicinally important primary and secondary metabolites. Understanding of PTMs in plants will help us to enhance the production of these metabolites without greatly altering the genome. This will give us robust eukaryotic systems for production and isolation of desired products without considerable downstream and isolation processes.
- Collects in one place a thorough insight into post translational modifications (PTMs) of proteins in both the plant and animal kingdom along with current techniques involved with studying PTMs
- Diagrammatic representation of various protein modification and estimation mechanisms in four-color
- Includes coverage of diseases involving post translational modifications
2. Post-translational modifications in plant proteins: Role in structure and Function
3. Advances in modificomics
4. Role of Glycosylation in plant proteins with therapeutic importance
5. Ubiquitination as a posttranslational modification: an update
6. Madhu Khanna Protein homocystinylation and structural consequences
7. Mass spectrometry in Post-translational modifications: an update
8. Nitrosylation in Acute myeloid leukemia
9. Extent of posttranslational modification in bacterial proteins
10. Role of phosphorylation and regulation of enzyme function
11. Effect of sumoylation in Toll-like Receptors (TLRs)
12. Glycation and human diseases
13. Translational plant proteomics: An Overview
14. Khan Quantitative proteomics by 2DE and MALDI MS/MS in Organic farming
15. Mass spectrometry for high throughput quantitative proteomics in plant research
16. Quantitative mass spectrometry in functional plant proteomics with special reference to phosphoproteins
17. Redox mediated post-translational modifications in plant proteins
18. Promising and Empowering contributions of Proteomics to systems biology in plants
Dr. Dar received his Masters in Biochemistry for Hamdard University, New Delhi, India in 2003 and PhD in Biosciences from Jamia Millia Islamia, New Delhi in 2009. After completing his Doctorate, Dr. Dar joined as post-doctorate in Prof. Bruce Bowler's lab at University of Montana, Missoula, USA. He is currently working as Sr. Assistant Professor, Clinical Biochemistry, University of Kashmir. He has focussed his research mainly on fibrillation/aggregation of proteins in presence of chemical chaperones and also the structural and functional characterization of therapeutic proteins from medicinal plants. He has authored about 30 publications in both national and international journals of repute in the field of protein biophysics and their co-solvent engineering in presence of chemical chaperones/osmolytes like sucrose, glucose, trehalose etc. In addition to this, Dr. Dar is involved in structural and functional characterization of glycosylated therapeutic proteins from medicinal plants. He has recently co-authored an edited volume book published by Springer, International Ltd. and is also a recipient of INSA visiting fellowship for the year 2014-2015.
Singh, Laishram Rajendrakumar
Dr. Laishram R. Singh is an Assistant Professor in the University of Delhi. He obtained his Masters Degree from Jamia Millia Islamia, New Delhi. After receiving Doctoral degree in protein Biophysics from Jamia Millia Islamia, New Delhi, Dr. Singh continued his postdoctoral research at Fox Chase cancer Center, Philadelphia (FCCC). During his Doctoral study he was engaged in investigating how small molecule compounds affect native protein structure, stability and enzymatic catalysis. At FCCC his main research interest encompasses understanding the Proteiostasis and modulators toward the functional restoration of mutant proteins including, mutants of p53, cystathionine beta synthase and methyl tetrahydrofolate reductase. Currently Dr. Singh (at Delhi University) is working on understanding the protein covalent modifications by toxic metabolites present in the serum. Dr. Singh is also a well-known enzymologist and protein biochemist. He has published more than 40 publications in many esteemed journals in the field of proteiostatic regulation and protein modification by homocystein and other aldehydic compounds.
Dr. Parvaiz, currently working as Senior Assistant Professor in Department of Botany at Sri Pratap College, Srinagar, Jammu and Kashmir, India, has completed his postgraduation in Botany in 2000 from Jamia Hamdard, New Delhi, India. After his Doctorate degree from the Indian Institute of Technology (IIT), Delhi, India, Dr. Ahmad joined the International Centre for Genetic Engineering and Biotechnology, New Delhi, in 2007. His research interest mainly includes Stress Physiology and Molecular Biology and has published more than 50 research papers in peer-reviewed journals and 40 book chapters. He is also an Editor of 17 volumes (1 with Studium Press Pvt. India Ltd., New Delhi, India, 9 with Springer NY USA, 5 with Elsevier USA and 3 with John Wiley). Department of Science and Technology (DST), Govt. of India in 2007 awarded Young Scientist Award under Fast Track scheme to him. Dr. Parvaiz is actively engaged in studying the molecular and physio-biochemical responses of different agricultural and horticultural plants under environmental stress.