Mechanisms of DNA Recombination and Genome Rearrangements: Intersection Between Homologous Recombination, DNA Replication and DNA Repair, Vol 601. Methods in Enzymology

  • ID: 4398611
  • Book
  • 434 Pages
  • Elsevier Science and Technology
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Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair, Volume 601, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field.

Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination. The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts.

  • contributions by the leading experts in the field of DNA repair, recombination, replication and genome stability
  • documents cutting edge methods

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- Using the Flp Recombinase to Induce Site-Specific Protein-DNA Nicks

Kristoffer P. Jakobsen and Lotte Bjergbæk

- A Proximity Ligation-Based Method for Quantitative Measurement of D-Loop Extension in S. cerevisiae

Aurèle Piazza, Romain Koszul and Wolf-Dietrich Heyer

- Inducing and Detecting Mitotic DNA Synthesis at Difficult-to-Replicate Loci

Lorenza Garribba, Wei Wu, Özgün Özer, Rahul Bhowmick, Ian D. Hickson and Ying Liu

- An Approach to Detect and Study DNA Double-Strand Break Repair by Transcript RNA Using a Spliced-Antisense RNA Template

Havva Keskin and Francesca Storici

- Assaying Repair at DNA Nicks

Luther Davis, Yinbo Zhang and Nancy Maizels

- Recovery of Alternative End-Joining Repair Products From Drosophila Embryos

Terrence Hanscom, Varandt Y. Khodaverdian and Mitch McVey

- High-Throughput Analysis of DNA Break-Induced Chromosome Rearrangements by Amplicon Sequencing

Alexander J. Brown, Aneesa T. Al-Soodani, Miles Saul, Stephanie Her, Juan C. Garcia, Dale A. Ramsden, Chengtao Her and Steven A. Roberts

- Assaying Mutations Associated With Gene Conversion Repair of a Double-Strand Break

Gajendrahar Dwivedi and James E. Haber

- Investigation of Break-Induced Replication in Yeast

Rajula Elango, Zachary Kockler, Liping Liu and Anna Malkova

- Targeting Allostery With Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities

Davide Moiani, Daryl A. Ronato, Chris A. Brosey, Andrew S. Arvai, Aleem Syed, Jean-Yves Masson, Elena Petricci and John A. Tainer

- Integrating Experimental and In Silico HTS in the Discovery of Inhibitors of Protein-Nucleic Acid Interactions

Quinn Li, Laura Folly da Silva Constantino and Michael A. Spies

- Monitoring Recombination During Meiosis in Budding Yeast

Shannon Owens, Shangming Tang and Neil Hunter

- S1-seq Assay for Mapping Processed DNA Ends

Eleni P. Mimitou and Scott Keeney

- Methods for Controlled Protein Depletion to Study Protein Function During Meiosis

Hardeep Kaur, Jasvinder S. Ahuja and Michael Lichten

- Quantitative Methods to Investigate the 4D Dynamics of Heterochromatic Repair Sites in Drosophila Cells

Christopher P. Caridi, Laetitia Delabaere, Harianto Tjong, Hannah Hopp, Devika Das, Frank Alber and Irene Chiolo

- Analysis of Meiotic Double-Strand Break Initiation in Mammals

Kevin Brick, Florencia Pratto, Chi-Yu Sun, Rafael D. Camerini-Otero and Galina Petukhova
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