Drug Selectivity. An Evolving Concept in Medicinal Chemistry. Methods and Principles in Medicinal Chemistry

  • ID: 4449304
  • Book
  • 536 Pages
  • John Wiley and Sons Ltd
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The book provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process.

The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide–ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.

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PART I. INTRODUCTION

Polypharmacology in Drug Discovery

PART II. SELECTIVITY OF MARKTETED DRUGS

Kinase Inhibitors

New Indications for Marketed Drugs

Discovery Technologies of New Indications

PART III. FIXED–DOSE COMBINATIONS

The Growing Market of Fixed–Dose Combinations

PART IV. UNSELECTIVE DRUGS IN DRUG DISCOVERY

The Growing Importance of Individualising Drugs

Drug Discovery Strategies for the Generation of Multi–Target Ligands against Neglected Tropical Diseases

Designing–In Approach

The Linker Approach (Drug–Conjugates)

Merged Multiple Ligands

Pharmacophore Generation of Multiple Ligands

Cellular Assays

PART V. THERAPEUTIC AREAS FOR DESIGNED MULTIPLE LIGANDS

5HT Transporter–Based Multiple Ligands for Depression

Multiple Ligands Targeting the Angiotensin System for Hypertension

PPAR–Based Multiple Ligands for Metabolic Disease

Antibiotics

Multiple Ligands in Cancer Therapy

Multiple Ligands in Neurodegenerative Diseases

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Norbert Handler
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