Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors

Table of Contents

1. Introduction: An Overview of the Anatomy and Physiology of the Brain
2. Angiogenesis in brain tumors
3. Physiology of the Blood Brain Barrier (BBB) and mechanisms of Transport across the BBB
4. Active Targeting Systems (Ligands) / Receptor overexpressed on brain
5. Nanotechnology in Brain Targeting
6. Polymeric nanoparticles based drug delivery for brain tumors
7. Solid lipid nanoparticles (SLN)based drug delivery for brain tumors
8. Liposomes based drug delivery for brain tumors
9. Dendrimers based drug delivery for brain tumors
10. Micelles based drug delivery for brain tumors
11. Nanoemulsions based drug delivery for brain tumors
12. Nanogel based drug delivery for brain tumors
13. Beyond the blood-brain barrier facing new challenges
14. Towards development of neuro-diagnostic nano-imaging platform
15. Future prospects of nanoparticles on brain targeted drug delivery

Authors

Prashant Kesharwani Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India. Dr. Prashant Kesharwani is Assistant Professor of Pharmaceutics at the School of Pharmaceutical Education and Research, Jamia Hamdard University, New Delhi, India. He has published more than 150 articles in well reputed international journals and edited 10 international books. Dr. Kesharwani has received several awards, including the 'Ramanujan Fellowship, DST, India-2017', 'Excellence Research Award 2014', 'Young Innovator Award (Gold medal) 2012', 'International Travel Award/Grant from DST (New Delhi) and INSA (CCSTDS, Chennai) 2012', as well as receiving an ICMR Senior Research Fellowship (PhD) and AICTE Junior Research Fellowship (M. Pharm.). He has presented invited talks and presentations at prestigious conferences, supervised students/junior researchers, and actively participated in outreach and scientific dissemination for the service of the wider community. Dr. Kesharwani's current research is focused on the development of nano-engineered drug delivery systems for various diseases. Umesh Gupta Assistant Professor, Department fo Pharmacy, Central University of Rajasthan, India. Dr. Umesh Gupta, currently working as Assistant Professor at Department of Pharmacy, Central University of Rajasthan, India, did his bachelor's, master's and doctorate degree in Pharmaceutical Sciences from Dr. H. S. Gour University, India under the mentorship of Prof. NK Jain. He has recently been awarded for "DAAD Research Stays for Academics and Scientists” at Leibniz-institut fur Polymerforschung Dresden, Germany. He has the past experience of Research Scientist at Ranbaxy Research Laboratories, India and Post-Doctoral Research Associate at South Dakota State University, USA. HE is also recipient of Young Scientist Award by Department of Science and Technology, Government of India as well as Ranbaxy Science Scholar Award 2008 by Ranbaxy Research Laboratories, India. He has been awarded more than 3-4 times the overseas travel award by different funding agencies of Indian government to share and present his research at international platform in countries like Germany, USA and Singapore etc. He has more than ten years of research and academic experience. The area of research is mainly focused on dendrimer mediated drug delivery, solubilization and targeting. His laboratory equally focuses on effective brain delivery through nanotechnological carriers such as polymeric micelles, nanoparticles and dendrimers. He has more than 48 publications and seven book chapters to his credit with total citations of more than 2300 (h index of 23 as per Google Scholar).