Drug Overview: Lupron

  • ID: 4462178
  • Drug Pipelines
  • 9 pages
  • Datamonitor Healthcare
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Drug Overview

Lupron (leuprolide; Takeda/AbbVie) is a gonadotropin-releasing hormone (GnRH) agonist which acts on the pituitary gland in the brain to stimulate luteinizing hormone (LH) release, resulting in a temporary surge in serum testosterone levels known as "flare." With continued use, GnRH agonists such as Lupron cause downregulation of GnRH receptors in the pituitary gland, generating a significant reduction in LH and follicle-stimulating hormone secretion. This has the effect of complete shutdown of testosterone production in the testes, resulting in chemical castration where levels of the hormone drop by up to 95% and tumor growth is significantly reduced.
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Product Profiles
Lupron: Prostate cancer

List of Figures
Figure 1: Lupron sales for prostate cancer across the US, Japan, and five major EU markets, by country, 2017-26

List of Tables
Table 1: Lupron sales for prostate cancer across the US, Japan, and five major EU markets, by country ($m), 2017-26
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