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Mechanochemistry. Principles, Methods and Applications

  • Book
  • 350 Pages
  • July 2019
  • John Wiley and Sons Ltd
  • ID: 4470391
Filling a huge gap and bridging the knowledge between the various subdisciplines, this is a well–structured overview for both beginners and more advanced researchers in academia and industry. The two experienced and excellent scientist authors include many applications, so that readers can see how the theories are applied in real life.
A must–have for many inorganic and organic chemists, material and life scientists, as well as pharmaceutical developers.

Table of Contents

INTRODUCTION
definitions and history
advantages
green chemistry
solvent–free chemistry
solvent–limited chemistry
energy–limited chemistry
biochemical context

METHODS AND INSTRUMENTS
Manual methods
Mechanically activated ageing
Grinder mills
Planetary mills
Screw extrusion
Equipment choice, design and manufacture

CHARACTERISATION
Diffraction techniques
Spectroscopic techniques
Thermal analysis

MECHANISMS
Stepwise mechanisms
Formation of intermediatesTopological considerations
Amorphous phase formation
Thermodynamic rationalisations/phase diagram interpretations

ADVANCED METHODS AND CATALYSIS
Catalysis
Liquid–assisted grinding (LAG)
Ion– and liquid–assisted grinding (ILAG)
Grinding–annealing techniques

ORGANIC SYNTHESIS
Different types of organic reactions
Approaches – stepwise and single–step (one–pot) synthesis

METAL–ORGANIC SYNTHESIS AND METAL–ORGANIC FRAMEWORKS (MOFS)
Design
Small molecules
Linear and sheet polymers
Porous and non–porous MOFs
Zeolitic imidazolate frameworks
Porosity and functional behaviour
Mechanisms and mechanochemical interconversion of porous/non–porous topologies

SUPRAMOLECULAR SYNTHESIS
Design
Molecular recognition: cocrystals, inclusion complexes
One–pot multiple recognition and molecular assembly process
Solid–state self–assembly: small molecules and molecular cages
Computational/theoretical approaches

INORGANIC SYNTHESIS
Design
Mixed salts and oxides
Composite materials
Alloying
Nano–sized materials

COMPARISON TO RELATED TECHNIQUES
Sonochemistry
Microwave synthesis

PHARMACEUTICAL AND INDUSTRIAL APPLICATIONS
Solid forms
Cocrystals
Salts
Screening
Scaling–up methods

RELATED SOLID–STATE METHODOLOGIES
Topochemistry
Photochemical solid–state reactions
Thermochemical solid–state reactions
Gas–solid reactions
Microscopic methods: nanoscratching and nanoindentation

SELECTED PRACTICAL PREPARATIVE EXPERIMENTS
Supramolecular
Metal–organic
Organic
Inorganic

Authors

Jonathan W. Steed Tomislav Friscic